STRINGSTRING
ITGA5 ITGA5 VWF VWF LAMA3 LAMA3 LAMA4 LAMA4 THBS1 THBS1 LAMC3 LAMC3 SV2A SV2A SPP1 SPP1 DMP1 DMP1 FREM2 FREM2 COL4A2 COL4A2 ITGA8 ITGA8 ITGA9 ITGA9 COL4A6 COL4A6 COMP COMP COL1A2 COL1A2 CD36 CD36 RELN RELN LAMB1 LAMB1 LAMC2 LAMC2 LAMB3 LAMB3 FN1 FN1 COL4A3 COL4A3 ITGA2 ITGA2 GP1BA GP1BA THBS4 THBS4 GP6 GP6 ITGA3 ITGA3 GP1BB GP1BB GP5 GP5 SDC1 SDC1 IBSP IBSP TNXB TNXB ITGB1 ITGB1 HMMR HMMR ITGAV ITGAV ITGA6 ITGA6 AGRN AGRN COL2A1 COL2A1 ITGA7 ITGA7 LAMC1 LAMC1 LAMA2-2 LAMA2-2 CHAD CHAD ITGA10 ITGA10 GP9 GP9 COL9A3 COL9A3 HSPG2 HSPG2 LAMA1 LAMA1 ITGB7 ITGB7 ITGB6 ITGB6 THBS3 THBS3 SV2B SV2B DSPP DSPP COL4A5 COL4A5 LAMB2 LAMB2 SDC4 SDC4 COL4A4 COL4A4 ITGB5 ITGB5 LAMB4 LAMB4 ITGA11 ITGA11 DAG1 DAG1 TNN TNN FREM1 FREM1 LOC100517188 LOC100517188 THBS2 THBS2 COL9A1 COL9A1 COL4A1 COL4A1 CD47 CD47 COL9A2 COL9A2 COL6A1 COL6A1 COL1A1 COL1A1 ITGA1 ITGA1 FRAS1 FRAS1 ITGB4 ITGB4 COL6A6 COL6A6 ITGB3 ITGB3 NPNT NPNT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1057 aa)
VWFVon Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa)
LAMA3Laminin subunit alpha 3. (3345 aa)
LAMA4Laminin subunit alpha 4. (1815 aa)
THBS1Uncharacterized protein. (1170 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
SV2ASynaptic vesicle glycoprotein 2A isoform 1. (742 aa)
SPP1Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. (303 aa)
DMP1Dentin matrix acidic phosphoprotein 1. (531 aa)
FREM2FRAS1 related extracellular matrix 2. (3174 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
COL4A6Collagen type IV alpha 6 chain. (1547 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
CD36Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
RELNReelin. (3458 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
LAMC2Laminin subunit gamma-2 isoform a. (1191 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
FN1Fibronectin 1. (2462 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
GP1BAPlatelet glycoprotein Ib alpha polypeptide. (627 aa)
THBS4Thrombospondin 4. (976 aa)
GP6Ig-like domain-containing protein. (319 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa)
GP1BBPlatelet glycoprotein Ib beta chain. (203 aa)
GP5Glycoprotein V platelet. (569 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (309 aa)
IBSPBone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. (316 aa)
TNXBUncharacterized protein. (4137 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
HMMRHyaluronan mediated motility receptor. (722 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
AGRNAgrin. (2108 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1169 aa)
LAMC1Uncharacterized protein. (1607 aa)
LAMA2-2Uncharacterized protein. (921 aa)
CHADChondroadherin. (359 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1352 aa)
GP9Glycoprotein IX platelet. (173 aa)
COL9A3Collagen type IX alpha 3 chain. (684 aa)
HSPG2Heparan sulfate proteoglycan 2. (4346 aa)
LAMA1Laminin subunit alpha 1. (3079 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (882 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (854 aa)
THBS3Thrombospondin-3 isoform 1. (973 aa)
SV2BSynaptic vesicle glycoprotein 2B. (683 aa)
DSPPUncharacterized protein. (1023 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
LAMB2Laminin subunit beta-2. (1881 aa)
SDC4Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Belongs to the syndecan proteoglycan family. (353 aa)
COL4A4Collagen type IV alpha 4 chain. (1691 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
LAMB4Uncharacterized protein. (719 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1282 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (912 aa)
TNNTenascin N. (1472 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
LOC100517188Uncharacterized protein. (1592 aa)
THBS2Thrombospondin 2. (1223 aa)
COL9A1Collagen type IX alpha 1 chain. (922 aa)
COL4A1Collagen IV NC1 domain-containing protein. (461 aa)
CD47Leukocyte surface antigen CD47; Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. Plays an important role in memory formation and synaptic plasticity in the hippocampus. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeabili [...] (340 aa)
COL9A2Uncharacterized protein. (709 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1175 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4013 aa)
ITGB4Integrin beta. (1814 aa)
COL6A6Collagen type VI alpha 6 chain. (2266 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (835 aa)
NPNTNephronectin. (834 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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