STRINGSTRING
WNT10B WNT10B WNT1 WNT1 INHBE INHBE IGF1 IGF1 POU5F1 POU5F1 ZFHX3 ZFHX3 DVL1 DVL1 WNT4 WNT4 SMAD4 SMAD4 ONECUT1 ONECUT1 IGF1R IGF1R BMP4 BMP4 FZD6 FZD6 WNT8B WNT8B WNT2B WNT2B ID2 ID2 FZD10 FZD10 TBX3 TBX3 LHX5 LHX5 BMI1 BMI1 ZIC3 ZIC3 NEUROG1 NEUROG1 ACVR1C ACVR1C HOXD1 HOXD1 FZD7 FZD7 FZD5 FZD5 RIF1 RIF1 WNT16 WNT16 HOXA1 HOXA1 ISL1 ISL1 GRB2 GRB2 STAT3 STAT3 HOXB1 HOXB1 WNT11 WNT11 PCGF6 PCGF6 LEFTY2 LEFTY2 WNT10A WNT10A DVL2 DVL2 RAF1 RAF1 ID4 ID4 WNT8A WNT8A WNT3A WNT3A BMPR1B BMPR1B HESX1 HESX1 FZD9 FZD9 WNT9A WNT9A TCF7 TCF7 WNT7B WNT7B LIFR LIFR JAK2 JAK2 MAP2K2 MAP2K2 FGFR1 FGFR1 FGFR2 FGFR2 FGFR4 FGFR4 IL6ST IL6ST JAK3 JAK3 INHBC INHBC TCF3 TCF3 CTNNB1 CTNNB1 SMARCAD1 SMARCAD1 JAK1 JAK1 SMAD1 SMAD1 SMAD5 SMAD5 WNT5B WNT5B PAX6 PAX6 FZD3 FZD3 SETDB1 SETDB1 LIF LIF PCGF2 PCGF2 APC2 APC2 APC APC WNT5A WNT5A ACVR2A ACVR2A MEIS1 MEIS1 BMPR1A BMPR1A ID1 ID1 HAND1 HAND1 FZD2 FZD2 WNT7A WNT7A FZD1 FZD1 DLX5 DLX5 JARID2 JARID2 NRAS NRAS AKT2 AKT2 GSK3B GSK3B OTX1 OTX1 WNT3 WNT3 PCGF5 PCGF5 NODAL NODAL DUSP9 DUSP9 AKT1 AKT1 ESRRB ESRRB HRAS HRAS WNT2 WNT2 INHBA INHBA MAPK12 MAPK12 PIK3CB PIK3CB PIK3CA PIK3CA LOC100511937 LOC100511937 ID3 ID3 AXIN2 AXIN2 ACVR1 ACVR1 NANOG NANOG MAP2K1 MAP2K1 WNT9B WNT9B KAT6A KAT6A MAPK3 MAPK3 PCGF1 PCGF1 INHBB INHBB WNT6 WNT6 FZD4 FZD4 PCGF3 PCGF3 MAPK14 MAPK14 MYF5 MYF5 ACVR2B ACVR2B BMPR2 BMPR2 AKT3 AKT3 MAPK13 MAPK13 REST REST ACVR1B ACVR1B MAPK1 MAPK1 SMAD3 SMAD3 MYC MYC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
INHBEInhibin subunit beta E. (350 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
POU5F1POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa)
ZFHX3Zinc finger homeobox 3. (3722 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
ONECUT1One cut domain family member. (465 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FZD6Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
LHX5LIM/homeobox protein Lhx5. (402 aa)
BMI1RING-type domain-containing protein. (336 aa)
ZIC3Zic family member 3. (467 aa)
NEUROG1Neurogenin 1. (246 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
HOXD1Homeobox D1. (327 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (586 aa)
RIF1Replication timing regulatory factor 1. (2466 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
HOXA1Homeobox protein Hox-A1 isoform X1. (336 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
HOXB1Homeobox protein Hox-B1. (301 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
PCGF6Polycomb group RING finger protein 6 isoform a. (351 aa)
LEFTY2Left-right determination factor. (366 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (415 aa)
DVL2Dishevelled segment polarity protein 2. (794 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
ID4DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). (161 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HESX1HESX homeobox 1. (185 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TCF7Transcription factor 7. (484 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LIFRLIF receptor subunit alpha. (1170 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
FGFR4Fibroblast growth factor receptor. (903 aa)
IL6STInterleukin 6 signal transducer. (938 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
INHBCInhibin beta C chain preproprotein. (354 aa)
TCF3Transcription factor E2-alpha isoform X12. (642 aa)
CTNNB1Catenin beta 1. (808 aa)
SMARCAD1Uncharacterized protein. (1029 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (359 aa)
PAX6Paired box 6. (498 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1332 aa)
LIFLeukemia inhibitory factor isoform X1. (202 aa)
PCGF2Polycomb group RING finger protein 2 isoform X1. (344 aa)
APC2Uncharacterized protein. (2292 aa)
APCAPC_basic domain-containing protein. (2713 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
MEIS1Homeobox protein Meis1. (465 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (154 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
DLX5Homeobox protein DLX-5. (290 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1245 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
OTX1Orthodenticle homeobox 1. (356 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
PCGF5Polycomb group RING finger protein 5 isoform X1. (256 aa)
NODALNodal growth differentiation factor. (316 aa)
DUSP9Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
ESRRBEstrogen related receptor beta. (458 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa)
MAPK12Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (386 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
ID3BHLH domain-containing protein. (118 aa)
AXIN2Axin-2. (843 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (729 aa)
NANOGHomeobox domain-containing protein. (304 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (829 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PCGF1RING-type domain-containing protein. (263 aa)
INHBBInhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (407 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa)
PCGF3Polycomb group ring finger 3. (258 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (253 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
MAPK13Mitogen-activated protein kinase. (435 aa)
RESTRE1 silencing transcription factor. (1108 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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