STRINGSTRING
CFL2 CFL2 PLCG2 PLCG2 PRKCG PRKCG PLA2G4F PLA2G4F PLA2G4D PLA2G4D JMJD7 JMJD7 ARPC5L ARPC5L LYN LYN PLCG1 PLCG1 ARPC1A ARPC1A NCF1 NCF1 PRKCE PRKCE WASF3 WASF3 ARPC3 ARPC3 CRKL CRKL INPPL1 INPPL1 ARPC5 ARPC5 PLPP1 PLPP1 SPHK1 SPHK1 PRKCA PRKCA PLD2 PLD2 SPHK2 SPHK2 AMPH AMPH ASAP3 ASAP3 RAF1 RAF1 WASF2 WASF2 CFL1 CFL1 FCGR2B FCGR2B CDC42 CDC42 PAK1 PAK1 ARPC1B ARPC1B SYK SYK VAV1 VAV1 RPS6KB2 RPS6KB2 CRK CRK PLA2G6 PLA2G6 ARPC4 ARPC4 PRKCB PRKCB PLD1 PLD1 INPP5D INPP5D SCIN SCIN WASF1 WASF1 AKT2 AKT2 VASP VASP PIP5K1C PIP5K1C WAS WAS ASAP1 ASAP1 FCGR3A FCGR3A AKT1 AKT1 ASAP2 ASAP2 PIK3CB PIK3CB DNM2 DNM2 PIK3CA PIK3CA LOC100511937 LOC100511937 PLA2G4E PLA2G4E LIMK2 LIMK2 PRKCD PRKCD FCGR1A FCGR1A MAP2K1 MAP2K1 MAPK3 MAPK3 PLA2G4A PLA2G4A ARF6 ARF6 MARCKS MARCKS HCK HCK PLPP2 PLPP2 PIP5K1B PIP5K1B VAV3 VAV3 RPS6KB1 RPS6KB1 PLPP3 PLPP3 PIP5K1A PIP5K1A RAC2 RAC2 AKT3 AKT3 VAV2 VAV2 MYO10 MYO10 LIMK1 LIMK1 MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CFL2Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). (166 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
PLA2G4FPhospholipase A2. (852 aa)
PLA2G4DPhospholipase A2. (812 aa)
JMJD7Phospholipase A2. (780 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (303 aa)
LYNTyrosine-protein kinase. (512 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
NCF1Uncharacterized protein. (378 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
WASF3Wiskott-Aldrich syndrome protein family member 3 isoform X1. (498 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] (1265 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
PLPP1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa)
SPHK1Sphingosine kinase 1 isoform 2. (481 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
PLD2Phospholipase. (933 aa)
SPHK2Sphingosine kinase 2. (653 aa)
AMPHUncharacterized protein. (678 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (904 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
WASF2Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa)
CFL1Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up- regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration (By similarity). (179 aa)
FCGR2BUncharacterized protein. (434 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (440 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (526 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
ARPC4Actin related protein 2/3 complex subunit 4. (231 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLD1Phospholipase. (1074 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
SCINAdseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] (715 aa)
WASF1WH2 domain-containing protein. (559 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
VASPVasodilator stimulated phosphoprotein. (389 aa)
PIP5K1CPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5. (702 aa)
WASWASP actin nucleation promoting factor. (500 aa)
ASAP1Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1. (1129 aa)
FCGR3ALow affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. (259 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
ASAP2Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform a. (1010 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (877 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
PLA2G4EPhospholipase A2. (872 aa)
LIMK2LIM domain kinase 2. (793 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
FCGR1AUncharacterized protein. (362 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PLA2G4APhospholipase A2. (758 aa)
ARF6ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (By similarity). Required for normal completion of mitotic cytokinesis (By similarity). Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity). Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (By similarity). Plays an important role in membrane trafficking, during junctional remodeling and epithelial po [...] (175 aa)
MARCKSMyristoylated alanine rich protein kinase C substrate. (332 aa)
HCKTyrosine-protein kinase. (527 aa)
PLPP2Phospholipid phosphatase 2. (368 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (558 aa)
VAV3Vav guanine nucleotide exchange factor 3. (874 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PLPP3acidPPc domain-containing protein. (369 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa)
RAC2Rac family small GTPase 2. (217 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
VAV2Vav guanine nucleotide exchange factor 2. (879 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2069 aa)
LIMK1LIM domain kinase 1. (681 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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