STRINGSTRING
ADCY6 ADCY6 GLS2 GLS2 GNB3 GNB3 SLC38A2 SLC38A2 GRM4 GRM4 GRIK5 GRIK5 GRIN2D GRIN2D PRKCG PRKCG SLC1A7 SLC1A7 GRIK2 GRIK2 PLA2G4F PLA2G4F PLA2G4D PLA2G4D JMJD7 JMJD7 SLC1A1 SLC1A1 GNAI3 GNAI3 GNB2 GNB2 GNG13 GNG13 PPP3CA PPP3CA GNAI2 GNAI2 GRM2 GRM2 CACNA1D CACNA1D PLCB3 PLCB3 SLC1A2 SLC1A2 SLC17A6 SLC17A6 GNG14 GNG14 SLC1A6 SLC1A6 HOMER3 HOMER3 GRM6 GRM6 GRIK4 GRIK4 GNGT1 GNGT1 GRM3 GRM3 GNAI1 GNAI1 ADCY1 ADCY1 PRKCA PRKCA PLD2 PLD2 GRIA4 GRIA4 ADCY5 ADCY5 GNG2 GNG2 GRM8 GRM8 GNG8 GNG8 GRIN3B GRIN3B GRIN2C GRIN2C ITPR2 ITPR2 GRIK1 GRIK1 GRM5 GRM5 GNAS-2 GNAS-2 PPP3CB PPP3CB GRIA3 GRIA3 SLC1A3 SLC1A3 GNB5 GNB5 GRIN2B GRIN2B SLC17A8 SLC17A8 GNG3 GNG3 HOMER1 HOMER1 SHANK2 SHANK2 GRIA1 GRIA1 ADCY7 ADCY7 PRKACA PRKACA GNAQ GNAQ PRKCB PRKCB GNB4 GNB4 PLD1 PLD1 PLCB4 PLCB4 CACNA1A CACNA1A GNAO1 GNAO1 CACNA1C CACNA1C LOC110255211 LOC110255211 GLUL GLUL GRIA2 GRIA2 GRM7 GRM7 SHANK3 SHANK3 GRIK3 GRIK3 GRM1 GRM1 ADCY8 ADCY8 GNB1 GNB1 GRIN1 GRIN1 DLGAP1 DLGAP1 ADCY9 ADCY9 HOMER2 HOMER2 PLA2G4E PLA2G4E GLS GLS ADCY4 ADCY4 ITPR3 ITPR3 MAPK3 MAPK3 GRIN2A GRIN2A ADCY3 ADCY3 TRPC1 TRPC1 GRIN3A GRIN3A PLA2G4A PLA2G4A PRKACB PRKACB PLCB2 PLCB2 PPP3R1 PPP3R1 KCNJ3 KCNJ3 GRK3 GRK3 ITPR1 ITPR1 SLC17A7 SLC17A7 PLCB1 PLCB1 SHANK1 SHANK1 LOC100621431 LOC100621431 GNG10 GNG10 DLG4 DLG4 SLC38A3 SLC38A3 MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
GLS2Glutaminase 2. (602 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1. (340 aa)
SLC38A2Solute carrier family 38 member 2. (406 aa)
GRM4Glutamate metabotropic receptor 4. (966 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (980 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1332 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
SLC1A7Amino acid transporter. (560 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
PLA2G4FPhospholipase A2. (852 aa)
PLA2G4DPhospholipase A2. (812 aa)
JMJD7Phospholipase A2. (780 aa)
SLC1A1Amino acid transporter. (524 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG13G protein subunit gamma 13. (67 aa)
PPP3CASerine/threonine-protein phosphatase. (523 aa)
GNAI2G protein subunit alpha i2. (355 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2211 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
SLC1A2Amino acid transporter. (639 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
SLC1A6Amino acid transporter. (564 aa)
HOMER3Homer protein homolog 3 isoform X1. (359 aa)
GRM6Glutamate metabotropic receptor 6. (872 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
PLD2Phospholipase. (933 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (884 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (248 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1031 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (872 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (949 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
PPP3CBSerine/threonine-protein phosphatase. (527 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
SLC1A3Amino acid transporter. (498 aa)
GNB5G protein subunit beta 5. (420 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
SLC17A8Solute carrier family 17 member 8. (544 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (240 aa)
HOMER1Homer scaffold protein 1. (365 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1825 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GNB4G protein subunit beta 4. (340 aa)
PLD1Phospholipase. (1074 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CACNA1AUncharacterized protein. (434 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform b. (354 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1291 aa)
LOC110255211Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (125 aa)
GLULGlutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts. Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating [...] (509 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GRM7Metabotropic glutamate receptor 7 isoform X1. (921 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1740 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (999 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GNB1G protein subunit beta 1. (395 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
DLGAP1Disks large-associated protein 1 isoform X1. (982 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1379 aa)
HOMER2Homer scaffold protein 2. (343 aa)
PLA2G4EPhospholipase A2. (872 aa)
GLSGlutaminase. (669 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
ADCY3Adenylate cyclase 3. (1320 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
PLA2G4APhospholipase A2. (758 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PPP3R1Uncharacterized protein. (188 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (675 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
SLC17A7Solute carrier family 17 member 7. (567 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
SHANK1Uncharacterized protein. (308 aa)
LOC100621431Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (234 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (764 aa)
SLC38A3Sodium-coupled neutral amino acid transporter 3 isoform X1. (552 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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