STRINGSTRING
IGF1 IGF1 PRKCG PRKCG PLA2G4F PLA2G4F PLA2G4D PLA2G4D JMJD7 JMJD7 IGF1R IGF1R CRH CRH LYN LYN GNAI3 GNAI3 GUCY1A1 GUCY1A1 GNAZ GNAZ GNAI2 GNAI2 PLCB3 PLCB3 PPP2CA PPP2CA GNAI1 GNAI1 PRKCA PRKCA CRHR1 CRHR1 GNA11 GNA11 PPP2R1B PPP2R1B GUCY1A2 GUCY1A2 RAF1 RAF1 LOC100625149 LOC100625149 ITPR2 ITPR2 GNAS-2 GNAS-2 GRIA3 GRIA3 MAP2K2 MAP2K2 ARAF ARAF PRKG2 PRKG2 GRIA1 GRIA1 GNAQ GNAQ PRKCB PRKCB PLCB4 PLCB4 CACNA1A CACNA1A GNA13 GNA13 GNAO1 GNAO1 PRKG1 PRKG1 GNA12 GNA12 GRIA2 GRIA2 NRAS NRAS GRM1 GRM1 GUCY1B1 GUCY1B1 HRAS HRAS PLA2G4E PLA2G4E PPP2R1A PPP2R1A MAP2K1 MAP2K1 ITPR3 ITPR3 NOS1 NOS1 MAPK3 MAPK3 PLA2G4A PLA2G4A PLCB2 PLCB2 ITPR1 ITPR1 PLCB1 PLCB1 PPP2CB PPP2CB MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
PLA2G4FPhospholipase A2. (852 aa)
PLA2G4DPhospholipase A2. (812 aa)
JMJD7Phospholipase A2. (780 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CRHCorticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. (191 aa)
LYNTyrosine-protein kinase. (512 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-1 isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
GNAZGuanine nucleotide-binding protein G(Z) subunit alpha isoform X1. (355 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). (309 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
CRHR1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (415 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C (By similarity). (359 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. (709 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (735 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
LOC100625149Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (676 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ARAFSerine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). (609 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CACNA1AUncharacterized protein. (434 aa)
GNA13G protein subunit alpha 13. (377 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform b. (354 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
GNA12G protein subunit alpha 12. (382 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (649 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PLA2G4EPhospholipase A2. (872 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (578 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
NOS1Nitric oxide synthase 1. (1468 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PLA2G4APhospholipase A2. (758 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
PPP2CBSerine/threonine-protein phosphatase. (476 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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