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ADCY6 ADCY6 IGF1 IGF1 CPEB1 CPEB1 CCNB2 CCNB2 IGF1R IGF1R MOS MOS GNAI3 GNAI3 SPDYA SPDYA CCNA1 CCNA1 ANAPC5 ANAPC5 MAPK8 MAPK8 GNAI2 GNAI2 RPS6KA6 RPS6KA6 CDC23 CDC23 CDC25C CDC25C PGR PGR GNAI1 GNAI1 ADCY1 ADCY1 STK10 STK10 ANAPC7 ANAPC7 ADCY5 ADCY5 RAF1 RAF1 ANAPC4 ANAPC4 CCNB1 CCNB1 PLK1 PLK1 MAD2L2 MAD2L2 KIF22 KIF22 MAPK10 MAPK10 ARAF ARAF MAD2L1 MAD2L1 HSP90AB1 HSP90AB1 SPDYC SPDYC ADCY7 ADCY7 PRKACA PRKACA ANAPC1 ANAPC1 CDC26 CDC26 AURKA AURKA PDE3B PDE3B ANAPC13 ANAPC13 CPEB2 CPEB2 MAD1L1 MAD1L1 CCNB3 CCNB3 A0A287AFW9_PIG A0A287AFW9_PIG CDK1 CDK1 INS INS HSP90AA1 HSP90AA1 AKT2 AKT2 ADCY8 ADCY8 CDC25B CDC25B ADCY9 ADCY9 CDC25A CDC25A AKT1 AKT1 FZR1 FZR1 MAPK12 MAPK12 LOC100520556 LOC100520556 PIK3CB PIK3CB PIK3CA PIK3CA LOC100511937 LOC100511937 CPEB4 CPEB4 CDC27 CDC27 MAP2K1 MAP2K1 ADCY4 ADCY4 MAPK3 MAPK3 ADCY3 ADCY3 PRKACB PRKACB ANAPC10 ANAPC10 MAPK14 MAPK14 ANAPC11 ANAPC11 RPS6KA3 RPS6KA3 AKT3 AKT3 MAPK13 MAPK13 BUB1 BUB1 MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
CPEB1Uncharacterized protein. (602 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (396 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
MOSProto-oncogene serine/threonine-protein kinase mos. (345 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (394 aa)
CCNA1Cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
ANAPC5Anaphase-promoting complex subunit 5 isoform X1. (755 aa)
MAPK8Mitogen-activated protein kinase. (411 aa)
GNAI2G protein subunit alpha i2. (355 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
CDC23Cell division cycle protein 23 homolog. (594 aa)
CDC25CM-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). (501 aa)
PGRProgesterone receptor isoform B. (934 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa)
STK10Serine/threonine kinase 10. (941 aa)
ANAPC7Anaphase promoting complex subunit 7. (597 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (809 aa)
CCNB1Cyclin B1 transcript variant 1; Belongs to the cyclin family. (435 aa)
PLK1Serine/threonine-protein kinase PLK. (601 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
KIF22Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (753 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
ARAFSerine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). (609 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (825 aa)
SPDYCSpeedy protein C isoform X2. (354 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
ANAPC1Anaphase promoting complex subunit 1. (1944 aa)
CDC26Cell division cycle 26. (107 aa)
AURKAAurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation [...] (408 aa)
PDE3BPhosphodiesterase. (1117 aa)
ANAPC13Anaphase-promoting complex subunit 13. (74 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (1035 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (737 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1338 aa)
A0A287AFW9_PIGProtein kinase domain-containing protein. (377 aa)
CDK1Cyclin-dependent kinase 1 isoform 1; Belongs to the protein kinase superfamily. (297 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
CDC25BM-phase inducer phosphatase 2 isoform 1. (631 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1379 aa)
CDC25AM-phase inducer phosphatase 1 isoform a. (524 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
FZR1Fizzy and cell division cycle 20 related 1. (493 aa)
MAPK12Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (386 aa)
LOC100520556Uncharacterized protein. (231 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (725 aa)
CDC27Cell division cycle 27. (825 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
ADCY3Adenylate cyclase 3. (1320 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
ANAPC10DOC domain-containing protein. (193 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ANAPC11RING-type domain-containing protein. (411 aa)
RPS6KA3Ribosomal protein S6 kinase. (744 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
MAPK13Mitogen-activated protein kinase. (435 aa)
BUB1BUB1 mitotic checkpoint serine/threonine kinase. (1085 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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