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| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa) |
| | HSP90B1 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa) |
| | OPRM1 | Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (418 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | ESR2 | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. (526 aa) |
| | CREB3L4 | cAMP responsive element binding protein 3 like 4. (395 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa) |
| | CALML5 | Calmodulin like 5. (149 aa) |
| | GNAI2 | G protein subunit alpha i2. (355 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (493 aa) |
| | PGR | Progesterone receptor isoform B. (934 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (520 aa) |
| | CREB5 | cAMP responsive element binding protein 5. (510 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | KRT35 | Keratin 35; Belongs to the intermediate filament family. (455 aa) |
| | KRT34 | IF rod domain-containing protein; Belongs to the intermediate filament family. (391 aa) |
| | KRT33A | IF rod domain-containing protein; Belongs to the intermediate filament family. (403 aa) |
| | KRT39 | Keratin 39; Belongs to the intermediate filament family. (490 aa) |
| | KRT28 | Keratin 28; Belongs to the intermediate filament family. (463 aa) |
| | KRT27 | IF rod domain-containing protein; Belongs to the intermediate filament family. (460 aa) |
| | KRT26 | Keratin 26; Belongs to the intermediate filament family. (469 aa) |
| | KRT25 | Keratin 25; Belongs to the intermediate filament family. (452 aa) |
| | KRT24 | Keratin 24; Belongs to the intermediate filament family. (537 aa) |
| | HSPA1L | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (641 aa) |
| | KCNJ5 | G protein-activated inward rectifier potassium channel 4; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. (419 aa) |
| | ADCY5 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa) |
| | KRT10 | Keratin 10; Belongs to the intermediate filament family. (573 aa) |
| | KRT23 | Keratin 23; Belongs to the intermediate filament family. (416 aa) |
| | POMC | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. (381 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | LOC100516036 | IF rod domain-containing protein; Belongs to the intermediate filament family. (422 aa) |
| | KRT31 | IF rod domain-containing protein; Belongs to the intermediate filament family. (414 aa) |
| | SHC1 | SHC adaptor protein 1. (583 aa) |
| | GNAS-2 | Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | ATF6B | Activating transcription factor 6 beta. (717 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (373 aa) |
| | HSP90AB1 | Heat shock protein 90 alpha family class B member 1. (825 aa) |
| | KRT12 | Keratin 12; Belongs to the intermediate filament family. (519 aa) |
| | FKBP5 | Peptidylprolyl isomerase. (490 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa) |
| | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa) |
| | RARA | Retinoic acid receptor alpha isoform X1. (462 aa) |
| | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | HSPA8 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (680 aa) |
| | CTSD | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (408 aa) |
| | SP1 | Transcription factor Sp1 isoform a. (786 aa) |
| | EBAG9 | Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (230 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa) |
| | GNAO1 | Guanine nucleotide-binding protein G(O) subunit alpha isoform b. (354 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1463 aa) |
| | LOC100737030 | IF rod domain-containing protein; Belongs to the intermediate filament family. (452 aa) |
| | HSP90AA1 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (525 aa) |
| | KRT40 | Keratin 40; Belongs to the intermediate filament family. (427 aa) |
| | GRM1 | Glutamate metabotropic receptor 1. (1195 aa) |
| | TFF1 | P-type domain-containing protein. (86 aa) |
| | NCOA1 | Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...] (1441 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa) |
| | MMP9 | Matrix metalloproteinase-9. (708 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1379 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (785 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | LOC100511937 | Uncharacterized protein. (532 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | SHC3 | SHC adaptor protein 3. (656 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa) |
| | KRT14 | Keratin 14; Belongs to the intermediate filament family. (515 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | KCNJ6 | Potassium voltage-gated channel subfamily J member 6. (441 aa) |
| | ADCY3 | Adenylate cyclase 3. (1320 aa) |
| | SHC2 | Uncharacterized protein. (623 aa) |
| | PRKACB | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa) |
| | HBEGF | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa) |
| | GABBR2 | Gamma-aminobutyric acid type B receptor subunit 2. (958 aa) |
| | KCNJ3 | Potassium voltage-gated channel subfamily J member 3. (501 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa) |
| | FKBP4 | Peptidylprolyl isomerase. (455 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa) |
| | KRT18 | Keratin 18; Belongs to the intermediate filament family. (423 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | CALM3 | Uncharacterized protein; Belongs to the calmodulin family. (214 aa) |
| | KCNJ9 | Potassium voltage-gated channel subfamily J member 9. (505 aa) |
| | KRT36 | Keratin 36; Belongs to the intermediate filament family. (459 aa) |
| | GABBR1 | Gamma-aminobutyric acid type B receptor subunit 1. (1247 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (440 aa) |
| | CALML4 | Uncharacterized protein. (154 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa) |
| | HSPA6 | Heat shock 70 kDa protein 6; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (643 aa) |
| | MMP2 | Uncharacterized protein. (610 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (520 aa) |
| | KRT15 | Keratin 15; Belongs to the intermediate filament family. (526 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | LOC100515166 | IF rod domain-containing protein; Belongs to the intermediate filament family. (454 aa) |
