STRINGSTRING
ADCY6 ADCY6 HSP90B1 HSP90B1 OPRM1 OPRM1 SOS2 SOS2 ESR2 ESR2 CREB3L4 CREB3L4 GNAI3 GNAI3 TGFA TGFA SOS1 SOS1 CALML5 CALML5 GNAI2 GNAI2 PLCB3 PLCB3 CREB3L3 CREB3L3 PGR PGR GNAI1 GNAI1 CREB3L2 CREB3L2 CREB5 CREB5 ADCY1 ADCY1 GRB2 GRB2 KRT35 KRT35 KRT34 KRT34 KRT33A KRT33A KRT39 KRT39 KRT28 KRT28 KRT27 KRT27 KRT26 KRT26 KRT25 KRT25 KRT24 KRT24 HSPA1L HSPA1L KCNJ5 KCNJ5 ADCY5 ADCY5 RAF1 RAF1 KRT10 KRT10 KRT23 KRT23 POMC POMC ITPR2 ITPR2 GPER1 GPER1 LOC100516036 LOC100516036 KRT31 KRT31 SHC1 SHC1 GNAS-2 GNAS-2 SRC SRC MAP2K2 MAP2K2 ESR1 ESR1 ATF6B ATF6B CREB3 CREB3 HSP90AB1 HSP90AB1 KRT12 KRT12 FKBP5 FKBP5 ADCY7 ADCY7 PRKACA PRKACA RARA RARA GNAQ GNAQ CREB1 CREB1 HSPA8 HSPA8 CTSD CTSD SP1 SP1 EBAG9 EBAG9 PLCB4 PLCB4 GNAO1 GNAO1 NCOA2 NCOA2 LOC100737030 LOC100737030 HSP90AA1 HSP90AA1 NRAS NRAS AKT2 AKT2 KRT40 KRT40 GRM1 GRM1 TFF1 TFF1 NCOA1 NCOA1 ADCY8 ADCY8 NOS3 NOS3 MMP9 MMP9 ADCY9 ADCY9 AKT1 AKT1 HRAS HRAS ATF2 ATF2 PIK3CB PIK3CB PIK3CA PIK3CA LOC100511937 LOC100511937 PRKCD PRKCD SHC3 SHC3 MAP2K1 MAP2K1 ADCY4 ADCY4 ITPR3 ITPR3 KRT14 KRT14 MAPK3 MAPK3 KCNJ6 KCNJ6 ADCY3 ADCY3 SHC2 SHC2 PRKACB PRKACB PLCB2 PLCB2 HBEGF HBEGF GABBR2 GABBR2 KCNJ3 KCNJ3 ITPR1 ITPR1 FKBP4 FKBP4 PLCB1 PLCB1 KRT18 KRT18 EGFR EGFR CALM3 CALM3 KCNJ9 KCNJ9 KRT36 KRT36 GABBR1 GABBR1 FOS FOS CALML4 CALML4 AKT3 AKT3 HSPA6 HSPA6 MMP2 MMP2 CREB3L1 CREB3L1 KRT15 KRT15 MAPK1 MAPK1 LOC100515166 LOC100515166
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
HSP90B1Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. (804 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (418 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. (526 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
CALML5Calmodulin like 5. (149 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
PGRProgesterone receptor isoform B. (934 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CREB5cAMP responsive element binding protein 5. (510 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
KRT35Keratin 35; Belongs to the intermediate filament family. (455 aa)
KRT34IF rod domain-containing protein; Belongs to the intermediate filament family. (391 aa)
KRT33AIF rod domain-containing protein; Belongs to the intermediate filament family. (403 aa)
KRT39Keratin 39; Belongs to the intermediate filament family. (490 aa)
KRT28Keratin 28; Belongs to the intermediate filament family. (463 aa)
KRT27IF rod domain-containing protein; Belongs to the intermediate filament family. (460 aa)
KRT26Keratin 26; Belongs to the intermediate filament family. (469 aa)
KRT25Keratin 25; Belongs to the intermediate filament family. (452 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (537 aa)
HSPA1LHeat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] (641 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. (419 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
KRT10Keratin 10; Belongs to the intermediate filament family. (573 aa)
KRT23Keratin 23; Belongs to the intermediate filament family. (416 aa)
POMCCorticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. (381 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LOC100516036IF rod domain-containing protein; Belongs to the intermediate filament family. (422 aa)
KRT31IF rod domain-containing protein; Belongs to the intermediate filament family. (414 aa)
SHC1SHC adaptor protein 1. (583 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
SRCTyrosine-protein kinase. (559 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
ATF6BActivating transcription factor 6 beta. (717 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (825 aa)
KRT12Keratin 12; Belongs to the intermediate filament family. (519 aa)
FKBP5Peptidylprolyl isomerase. (490 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
HSPA8Uncharacterized protein; Belongs to the heat shock protein 70 family. (680 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. (408 aa)
SP1Transcription factor Sp1 isoform a. (786 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (230 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform b. (354 aa)
NCOA2Nuclear receptor coactivator. (1463 aa)
LOC100737030IF rod domain-containing protein; Belongs to the intermediate filament family. (452 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
KRT40Keratin 40; Belongs to the intermediate filament family. (427 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
TFF1P-type domain-containing protein. (86 aa)
NCOA1Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...] (1441 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa)
MMP9Matrix metalloproteinase-9. (708 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1379 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
SHC3SHC adaptor protein 3. (656 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
KRT14Keratin 14; Belongs to the intermediate filament family. (515 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (441 aa)
ADCY3Adenylate cyclase 3. (1320 aa)
SHC2Uncharacterized protein. (623 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (958 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
FKBP4Peptidylprolyl isomerase. (455 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (423 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (505 aa)
KRT36Keratin 36; Belongs to the intermediate filament family. (459 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (1247 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (440 aa)
CALML4Uncharacterized protein. (154 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
HSPA6Heat shock 70 kDa protein 6; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (643 aa)
MMP2Uncharacterized protein. (610 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
KRT15Keratin 15; Belongs to the intermediate filament family. (526 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
LOC100515166IF rod domain-containing protein; Belongs to the intermediate filament family. (454 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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