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ADCY6 ADCY6 NPPA NPPA NPR1 NPR1 GNAI3 GNAI3 CLCA2 CLCA2 GUCY1A1 GUCY1A1 EDNRA EDNRA PPP3CA PPP3CA ADRB1 ADRB1 CALML5 CALML5 GNAI2 GNAI2 CACNA1D CACNA1D PLCB3 PLCB3 GNAI1 GNAI1 ADRB3 ADRB3 ACE ACE PDE3A PDE3A GUCY1A2 GUCY1A2 ADCY5 ADCY5 LOC100625149 LOC100625149 CTSB CTSB PTGER4 PTGER4 ITPR2 ITPR2 PTGER2 PTGER2 GNAS-2 GNAS-2 PPP3CB PPP3CB AGT AGT AGTR1 AGTR1 PRKG2 PRKG2 PRKACA PRKACA GNAQ GNAQ CREB1 CREB1 PDE3B PDE3B CLCA1 CLCA1 PLCB4 PLCB4 EDN2 EDN2 ADORA1 ADORA1 CACNA1C CACNA1C EDN1 EDN1 ADCYAP1R1 ADCYAP1R1 REN REN GUCY1B1 GUCY1B1 CACNA1F CACNA1F ADRB2 ADRB2 ADCYAP1 ADCYAP1 ITPR3 ITPR3 ORAI1 ORAI1 PRKACB PRKACB KCNJ2 KCNJ2 PLCB2 PLCB2 AQP1 AQP1 PPP3R1 PPP3R1 PDE1A PDE1A ITPR1 ITPR1 PLCB1 PLCB1 EDN3 EDN3 LOC100515049 LOC100515049 CALM3 CALM3 PDE1B PDE1B CALML4 CALML4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (152 aa)
NPR1Guanylate cyclase. (1057 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CLCA2Chloride channel accessory 2. (943 aa)
GUCY1A1Guanylate cyclase soluble subunit alpha-1 isoform A; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
PPP3CASerine/threonine-protein phosphatase. (523 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (516 aa)
CALML5Calmodulin like 5. (149 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2211 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily. (407 aa)
ACEAngiotensin-converting enzyme. (1309 aa)
PDE3APhosphodiesterase. (1145 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (735 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
LOC100625149Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (676 aa)
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (By similarity). (416 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (489 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
PTGER2Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
PPP3CBSerine/threonine-protein phosphatase. (527 aa)
AGTAngiotensinogen; Belongs to the serpin family. (482 aa)
AGTR1Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
PDE3BPhosphodiesterase. (1117 aa)
CLCA1Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Induces a cAMP-dependent chloride conductance possibly through effects on CFTR in colon carcinoma cells. Belongs to the CLCR family. (915 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
EDN2Endothelin 2. (180 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1291 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
ADCYAP1R1Pituitary adenylate cyclase-activating polypeptide type I receptor short form; Belongs to the G-protein coupled receptor 2 family. (468 aa)
RENRenin preproprotein; Belongs to the peptidase A1 family. (407 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (649 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1977 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). (418 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). (176 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
ORAI1Uncharacterized protein. (408 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa)
PPP3R1Uncharacterized protein. (188 aa)
PDE1APhosphodiesterase. (545 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
EDN3Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (231 aa)
LOC100515049Angiotensin-converting enzyme. (771 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
PDE1BPhosphodiesterase. (535 aa)
CALML4Uncharacterized protein. (154 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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