STRINGSTRING
ADCY6 ADCY6 RXRB RXRB CDKN1A CDKN1A AKAP13 AKAP13 PRKCG PRKCG BGLAP BGLAP CREB3L4 CREB3L4 GNAI3 GNAI3 CYP24A1 CYP24A1 SLC34A2 SLC34A2 KL KL TNFSF11 TNFSF11 GNAI2 GNAI2 LRP5 LRP5 PLCB3 PLCB3 PTH PTH CREB3L3 CREB3L3 EGR1 EGR1 MMP13 MMP13 GNAI1 GNAI1 CREB3L2 CREB3L2 CREB5 CREB5 ADCY1 ADCY1 PRKCA PRKCA PLD2 PLD2 GNA11 GNA11 MMP17 MMP17 ADCY5 ADCY5 RAF1 RAF1 MMP14 MMP14 CYP27B1 CYP27B1 MMP25 MMP25 ITPR2 ITPR2 GNAS-2 GNAS-2 NACA NACA FGFR1 FGFR1 ARAF ARAF ATF6B ATF6B CREB3 CREB3 ARRB1 ARRB1 ADCY7 ADCY7 PRKACA PRKACA GCM1 GCM1 GNAQ GNAQ CREB1 CREB1 PRKCB PRKCB SP1 SP1 PLD1 PLD1 PLCB4 PLCB4 NR4A2 NR4A2 GNA13 GNA13 LRP6 LRP6 CASR CASR SLC34A1 SLC34A1 GCM2 GCM2 GATA3 GATA3 GNA12 GNA12 MMP16 MMP16 PTHLH PTHLH SOST SOST RHOA RHOA MMP24 MMP24 PDE4D PDE4D ADCY8 ADCY8 TRPV5 TRPV5 FGF23 FGF23 ADCY9 ADCY9 MMP15 MMP15 SLC34A3 SLC34A3 ATF2 ATF2 VDR VDR MAP2K1 MAP2K1 PDE4C PDE4C ADCY4 ADCY4 ITPR3 ITPR3 RXRG RXRG MAPK3 MAPK3 ADCY3 ADCY3 PRKACB PRKACB PLCB2 PLCB2 HBEGF HBEGF ARRB2 ARRB2 ITPR1 ITPR1 PLCB1 PLCB1 SLC9A3R1 SLC9A3R1 EGFR EGFR ARHGEF11 ARHGEF11 RUNX2 RUNX2 RXRA RXRA FOS FOS CREB3L1 CREB3L1 MAPK1 MAPK1 PDE4B PDE4B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
RXRBRetinoid X receptor beta. (536 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
AKAP13Uncharacterized protein. (1420 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CYP24A125-hydroxyvitamin D3-24-hydroxylase; Belongs to the cytochrome P450 family. (514 aa)
SLC34A2Sodium-dependent phosphate transport protein 2B isoform X1. (671 aa)
KLKlotho. (1011 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
GNAI2G protein subunit alpha i2. (355 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1233 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CREB5cAMP responsive element binding protein 5. (510 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1136 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
PLD2Phospholipase. (933 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C (By similarity). (359 aa)
MMP17Matrix metalloproteinase-17 preproprotein. (595 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa)
MMP25Matrix metallopeptidase 25. (566 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2702 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
NACAUncharacterized protein. (224 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
ARAFSerine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). (609 aa)
ATF6BActivating transcription factor 6 beta. (717 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
ARRB1Arrestin beta 1. (607 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1079 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
GCM1Glial cells missing transcription factor 1. (431 aa)
GNAQGuanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (359 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SP1Transcription factor Sp1 isoform a. (786 aa)
PLD1Phospholipase. (1074 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (609 aa)
GNA13G protein subunit alpha 13. (377 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
CASRExtracellular calcium-sensing receptor; G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as [...] (1089 aa)
SLC34A1Solute carrier family 34 member 1. (676 aa)
GCM2Glial cells missing transcription factor 2. (503 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
GNA12G protein subunit alpha 12. (382 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
PTHLHParathyroid hormone like hormone. (209 aa)
SOSTSclerostin. (212 aa)
RHOATransforming protein RhoA isoform 1. (193 aa)
MMP24Matrix metallopeptidase 24. (635 aa)
PDE4DPhosphodiesterase. (809 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1379 aa)
MMP15Matrix metallopeptidase 15. (712 aa)
SLC34A3Solute carrier family 34 member 3. (621 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
VDRVitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDE4CPhosphodiesterase. (729 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1102 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2680 aa)
RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
ADCY3Adenylate cyclase 3. (1320 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
HBEGFProheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa)
ARRB2Arrestin beta 2. (493 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (365 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1577 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
RXRARetinoid X receptor alpha. (701 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (440 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
PDE4BPhosphodiesterase. (736 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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