STRINGSTRING
PPARA PPARA PRKAG1 PRKAG1 NFKBIA NFKBIA PPP1R3E PPP1R3E GYS1 GYS1 NR1H2 NR1H2 MTOR MTOR SLC27A2 SLC27A2 CREB3L4 CREB3L4 SLC27A3 SLC27A3 PRKAB2 PRKAB2 IKBKB IKBKB PPP1R3D PPP1R3D PRKCE PRKCE MLXIP MLXIP PRKAB1 PRKAB1 MAPK8 MAPK8 PTEN PTEN PPP1R3C PPP1R3C PRKCQ PRKCQ RPS6KA6 RPS6KA6 CPT1A CPT1A RELA RELA NR1H3 NR1H3 CREB3L3 CREB3L3 INSR INSR PPARGC1B PPARGC1B CD36 CD36 G6PC2 G6PC2 PRKAG3 PRKAG3 PRKAG2 PRKAG2 CREB3L2 CREB3L2 PPP1R3A PPP1R3A CREB5 CREB5 STAT3 STAT3 SLC2A4 SLC2A4 CRTC2 CRTC2 IL6 IL6 PRKAA1 PRKAA1 PRKCZ PRKCZ PCK1 PCK1 MAPK10 MAPK10 FOXO1 FOXO1 AGT AGT PTPRF PTPRF CREB3 CREB3 PPARGC1A PPARGC1A RPS6KB2 RPS6KB2 SLC27A6 SLC27A6 SREBF1 SREBF1 PTPA PTPA GFPT1 GFPT1 PDPK1 PDPK1 TNFRSF1A TNFRSF1A CREB1 CREB1 PRKCB PRKCB GFPT2 GFPT2 PTPN1 PTPN1 PCK2 PCK2 CPT1B CPT1B INS INS PYGL PYGL AKT2 AKT2 GSK3B GSK3B G6PC G6PC OGA OGA NFKB1 NFKB1 MLXIPL MLXIPL NOS3 NOS3 SLC27A1 SLC27A1 PPP1CB PPP1CB AKT1 AKT1 GYS2 GYS2 SOCS3 SOCS3 PYGM PYGM IRS2 IRS2 PIK3CB PIK3CB PIK3CA PIK3CA LOC100511937 LOC100511937 PRKCD PRKCD SLC27A5 SLC27A5 G6PC3 G6PC3 PRKAA2 PRKAA2 TRIB3 TRIB3 PPP1CC PPP1CC SLC2A2 SLC2A2 IRS1 IRS1 PTPN11 PTPN11 COMMD6 COMMD6 PPP1R3B PPP1R3B RPS6KB1 RPS6KB1 SLC27A4 SLC27A4 ACACB ACACB PYGB PYGB RPS6KA3 RPS6KA3 AKT3 AKT3 CREB3L1 CREB3L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARAUncharacterized protein. (469 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (298 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (744 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (458 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
SLC27A2Solute carrier family 27 (Fatty acid transporter) member 2. (620 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
SLC27A3Long-chain fatty acid transport protein 3 isoform X1. (672 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
IKBKBInhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
MLXIPMLX interacting protein. (939 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] (271 aa)
MAPK8Mitogen-activated protein kinase. (411 aa)
PTENUncharacterized protein. (576 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (732 aa)
RPS6KA6Ribosomal protein S6 kinase. (745 aa)
CPT1AUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa)
RELATranscription factor p65 isoform 1. (573 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (470 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
PPARGC1BPeroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1. (1028 aa)
CD36Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (499 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1096 aa)
CREB5cAMP responsive element binding protein 5. (510 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (509 aa)
CRTC2CREB regulated transcription coactivator 2. (758 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (841 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
FOXO1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa)
AGTAngiotensinogen; Belongs to the serpin family. (482 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1919 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa)
RPS6KB2Non-specific serine/threonine protein kinase. (526 aa)
SLC27A6Solute carrier family 27 member 6. (655 aa)
SREBF1Processed sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). (1151 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (332 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (704 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (668 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
GFPT2Glutamine--fructose-6-phosphate aminotransferase isomerizing 2. (695 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform. (807 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (854 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
OGAO-GlcNAcase. (916 aa)
NFKB1Uncharacterized protein. (898 aa)
MLXIPLMLX interacting protein like. (970 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa)
SLC27A1Solute carrier family 27 (Fatty acid transporter), member 1. (646 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (389 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (699 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (1369 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa)
SLC27A5Solute carrier family 27 member 5. (710 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
TRIB3Tribbles pseudokinase 3. (373 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (369 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2; Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate; Belongs to the major fac [...] (559 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
COMMD6Uncharacterized protein. (1300 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (339 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SLC27A4Solute carrier family 27 member 4. (673 aa)
ACACBBiotin carboxylation domain-containing protein. (229 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
RPS6KA3Ribosomal protein S6 kinase. (744 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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