STRINGSTRING
ADCY6 ADCY6 CREB3L4 CREB3L4 DYNLL1 DYNLL1 CREB3L3 CREB3L3 RAB11B RAB11B CREB3L2 CREB3L2 CREB5 CREB5 AQP2 AQP2 DCTN4 DCTN4 GNAS-2 GNAS-2 CREB3 CREB3 DCTN5 DCTN5 RAB5A RAB5A DYNC1I2 DYNC1I2 PRKACA PRKACA RAB11A RAB11A CREB1 CREB1 DCTN6 DCTN6 AQP4 AQP4 DYNC2H1 DYNC2H1 DYNC1LI1 DYNC1LI1 DYNC2LI1 DYNC2LI1 STX4 STX4 ARHGDIA ARHGDIA NSF NSF DYNC1I1 DYNC1I1 ARHGDIB ARHGDIB ADCY9 ADCY9 DCTN1 DCTN1 DYNC1H1 DYNC1H1 AQP3 AQP3 ADCY3 ADCY3 PRKACB PRKACB DYNC1LI2 DYNC1LI2 DYNLL2 DYNLL2 VAMP2 VAMP2 RAB5C RAB5C DCTN2 DCTN2 CREB3L1 CREB3L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1164 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
DYNLL1Dynein light chain. (89 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
RAB11BUncharacterized protein. (205 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CREB5cAMP responsive element binding protein 5. (510 aa)
AQP2Aquaporin-2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (311 aa)
DCTN4Dynactin subunit 4. (501 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
DCTN5Dynactin subunit 5. (182 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
DYNC1I2WD_REPEATS_REGION domain-containing protein. (581 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
DCTN6Dynactin 6. (190 aa)
AQP4Aquaporin-4 isoform M1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4312 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
DYNC2LI1Dynein cytoplasmic 2 light intermediate chain 1. (402 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (338 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (270 aa)
NSFN-ethylmaleimide sensitive factor, vesicle fusing ATPase. (766 aa)
DYNC1I1Cytoplasmic dynein 1 intermediate chain 1 isoform X1. (645 aa)
ARHGDIBUncharacterized protein. (200 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1379 aa)
DCTN1CAP-Gly domain-containing protein. (1281 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4645 aa)
AQP3Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] (290 aa)
ADCY3Adenylate cyclase 3. (1320 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (492 aa)
DYNLL2Dynein light chain. (133 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (189 aa)
RAB5CUncharacterized protein. (227 aa)
DCTN2Dynactin subunit 2. (408 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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