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GRIN2D GRIN2D CREB3L4 CREB3L4 GNAI3 GNAI3 GNAI2 GNAI2 GRM2 GRM2 MAOA MAOA RELA RELA CREB3L3 CREB3L3 GRM3 GRM3 GNAI1 GNAI1 CREB3L2 CREB3L2 CREB5 CREB5 SLC6A3 SLC6A3 CDK5R1 CDK5R1 SLC18A2 SLC18A2 DRD1 DRD1 ADCY5 ADCY5 MAOB MAOB GRIN3B GRIN3B GRIN2C GRIN2C GNAS-2 GNAS-2 ATF6B ATF6B PDYN PDYN CREB3 CREB3 GRIN2B GRIN2B PRKACA PRKACA CREB1 CREB1 RGS9 RGS9 GRIA2 GRIA2 BDNF BDNF TH TH NFKB1 NFKB1 GRIN1 GRIN1 DRD2 DRD2 ATF2 ATF2 GRIN2A GRIN2A GRIN3A GRIN3A PRKACB PRKACB FOSB FOSB GPSM1 GPSM1 DDC DDC SLC18A1 SLC18A1 DLG4 DLG4 CREB3L1 CREB3L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1332 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GNAI2G protein subunit alpha i2. (355 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
MAOAAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (946 aa)
RELATranscription factor p65 isoform 1. (573 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CREB5cAMP responsive element binding protein 5. (510 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (614 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (315 aa)
SLC18A2MFS domain-containing protein. (517 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
MAOBAmine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (518 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1031 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (872 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
ATF6BActivating transcription factor 6 beta. (717 aa)
PDYNAlpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. (256 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
RGS9Regulator of G-protein signaling 9 isoform 2. (673 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (260 aa)
THTyrosine hydroxylase. (596 aa)
NFKB1Uncharacterized protein. (898 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (337 aa)
GPSM1G protein signaling modulator 1. (707 aa)
DDCAromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (529 aa)
SLC18A1Solute carrier family 18 member A1. (524 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (764 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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