STRINGSTRING
GRIN2D GRIN2D PRKCG PRKCG HDAC2 HDAC2 CREB3L4 CREB3L4 PPP3CA PPP3CA SIRT1 SIRT1 CALML5 CALML5 CACNA1D CACNA1D MAOA MAOA CREB3L3 CREB3L3 ARSI ARSI CREB3L2 CREB3L2 CREB5 CREB5 SLC6A3 SLC6A3 PRKCA PRKCA SLC18A2 SLC18A2 GRIA4 GRIA4 DRD1 DRD1 ADCY5 ADCY5 HDAC1 HDAC1 MAOB MAOB GRIN3B GRIN3B GRIN2C GRIN2C GNAS-2 GNAS-2 PPP3CB PPP3CB GRIA3 GRIA3 ATF6B ATF6B PDYN PDYN CREB3 CREB3 GRIN2B GRIN2B CAMK4 CAMK4 GRIA1 GRIA1 PRKACA PRKACA CREB1 CREB1 PRKCB PRKCB CACNA1C CACNA1C GRIA2 GRIA2 TH TH GRIN1 GRIN1 ARC ARC PPP1CB PPP1CB ATF2 ATF2 GRIN2A GRIN2A GRIN3A GRIN3A PRKACB PRKACB PPP1CC PPP1CC FOSB FOSB PPP3R1 PPP3R1 CAMK2B CAMK2B DDC DDC CALM3 CALM3 SLC18A1 SLC18A1 FOS FOS CALML4 CALML4 CREB3L1 CREB3L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1332 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
PPP3CASerine/threonine-protein phosphatase. (523 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa)
CALML5Calmodulin like 5. (149 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2211 aa)
MAOAAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (946 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
ARSIArylsulfatase family member I. (570 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CREB5cAMP responsive element binding protein 5. (510 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (614 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
SLC18A2MFS domain-containing protein. (517 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (884 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
MAOBAmine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (518 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1031 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (872 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
PPP3CBSerine/threonine-protein phosphatase. (527 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
ATF6BActivating transcription factor 6 beta. (717 aa)
PDYNAlpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. (256 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (534 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1291 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
THTyrosine hydroxylase. (596 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (389 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (369 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (337 aa)
PPP3R1Uncharacterized protein. (188 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (670 aa)
DDCAromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (529 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
SLC18A1Solute carrier family 18 member A1. (524 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (440 aa)
CALML4Uncharacterized protein. (154 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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