STRINGSTRING
GNB3 GNB3 LOC100152135 LOC100152135 LOC100152878 LOC100152878 LOC100154071 LOC100154071 GRIN2D GRIN2D HDAC2 HDAC2 SOS2 SOS2 PKIA PKIA CRH CRH CREB3L4 CREB3L4 H2AC21 H2AC21 H2AC20 H2AC20 LOC102159655 LOC102159655 GNAI3 GNAI3 GNB2 GNB2 GNG13 GNG13 SOS1 SOS1 H2AFZ H2AFZ CAMKK2 CAMKK2 ADORA2A ADORA2A CALML5 CALML5 GNAI2 GNAI2 LOC100520991 LOC100520991 MAOA MAOA CREB3L3 CREB3L3 GNG14 GNG14 GNGT1 GNGT1 GNAI1 GNAI1 HAT1 HAT1 CREB3L2 CREB3L2 CREB5 CREB5 LOC100519930 LOC100519930 SLC6A3 SLC6A3 LOC100521680 LOC100521680 GRB2 GRB2 HDAC5 HDAC5 CAMKK1 CAMKK1 SLC18A2 SLC18A2 ADORA2B ADORA2B DRD1 DRD1 ADCY5 ADCY5 RAF1 RAF1 HDAC1 HDAC1 MAOB MAOB HIST1H2BD HIST1H2BD GNG2 GNG2 HDAC10 HDAC10 LOC100158121 LOC100158121 GNG8 GNG8 GRIN3B GRIN3B GRIN2C GRIN2C HDAC11 HDAC11 LOC100621389 LOC100621389 SHC1 SHC1 GNAS-2 GNAS-2 ARAF ARAF ATF6B ATF6B PDYN PDYN CREB3 CREB3 GNB5 GNB5 GRIN2B GRIN2B CAMK4 CAMK4 GNG3 GNG3 A0A286ZTM7_PIG A0A286ZTM7_PIG PRKACA PRKACA CREB1 CREB1 GNB4 GNB4 NTRK2 NTRK2 GNAO1 GNAO1 NPY NPY LOC110255211 LOC110255211 MACROH2A2 MACROH2A2 H2AJ H2AJ NRAS NRAS H2BE1 H2BE1 BDNF BDNF TH TH GNB1 GNB1 H2BU1 H2BU1 GRIN1 GRIN1 DRD2 DRD2 PPP1CB PPP1CB HRAS HRAS SLC29A1 SLC29A1 ATF2 ATF2 HIST1H3E HIST1H3E SHC3 SHC3 H2BC21 H2BC21 MAP2K1 MAP2K1 MAPK3 MAPK3 GRIN2A GRIN2A HDAC6 HDAC6 SHC2 SHC2 GRIN3A GRIN3A PRKACB PRKACB H2AX H2AX PPP1CC PPP1CC FOSB FOSB H2AW H2AW HDAC8 HDAC8 MACROH2A1 MACROH2A1 DDC DDC CALM3 CALM3 LOC100621431 LOC100621431 SLC18A1 SLC18A1 SLC29A3 SLC29A3 CALML4 CALML4 HDAC9 HDAC9 GNG10 GNG10 CREB3L1 CREB3L1 MAPK1 MAPK1 H2AC1 H2AC1 HDAC4 HDAC4 HDAC7 HDAC7
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1. (340 aa)
LOC100152135Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC100152878Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC100154071Histone H2A; Belongs to the histone H2A family. (130 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1332 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PKIAcAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains; Belongs to the PKI family. (119 aa)
CRHCorticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. (191 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (395 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC102159655Histone H2A; Belongs to the histone H2A family. (130 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG13G protein subunit gamma 13. (67 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
H2AFZHistone H2A; Belongs to the histone H2A family. (128 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform 1. (578 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (414 aa)
CALML5Calmodulin like 5. (149 aa)
GNAI2G protein subunit alpha i2. (355 aa)
LOC100520991Histone H2A; Belongs to the histone H2A family. (122 aa)
MAOAAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (946 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (89 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1. (354 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (418 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
CREB5cAMP responsive element binding protein 5. (510 aa)
LOC100519930Histone domain-containing protein; Belongs to the histone H2B family. (122 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (614 aa)
LOC100521680Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] (136 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1131 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (532 aa)
SLC18A2MFS domain-containing protein. (517 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
DRD1D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. (446 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1259 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
MAOBAmine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (518 aa)
HIST1H2BDHistone H2B; Belongs to the histone H2B family. (126 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (248 aa)
HDAC10Histone deacetylase 10. (671 aa)
LOC100158121Histone H2A; Belongs to the histone H2A family. (130 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1031 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (872 aa)
HDAC11Histone deacetylase 11 isoform 1. (347 aa)
LOC100621389Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
SHC1SHC adaptor protein 1. (583 aa)
GNAS-2Guanine nucleotide-binding protein G(s) subunit alpha. (250 aa)
ARAFSerine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). (609 aa)
ATF6BActivating transcription factor 6 beta. (717 aa)
PDYNAlpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. (256 aa)
CREB3cAMP responsive element binding protein 3. (373 aa)
GNB5G protein subunit beta 5. (420 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (534 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (240 aa)
A0A286ZTM7_PIGHistone H3; Belongs to the histone H3 family. (136 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (357 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa)
GNB4G protein subunit beta 4. (340 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha isoform b. (354 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (169 aa)
LOC110255211Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (125 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (260 aa)
THTyrosine hydroxylase. (596 aa)
GNB1G protein subunit beta 1. (395 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa)
PPP1CBSerine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (389 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (548 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
HIST1H3EHistone H3; Belongs to the histone H3 family. (136 aa)
SHC3SHC adaptor protein 3. (656 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
HDAC6Histone deacetylase 6. (1159 aa)
SHC2Uncharacterized protein. (623 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] (394 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (369 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (337 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
HDAC8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (441 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
DDCAromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family. (529 aa)
CALM3Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
LOC100621431Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (234 aa)
SLC18A1Solute carrier family 18 member A1. (524 aa)
SLC29A3Solute carrier family 29 member 3. (529 aa)
CALML4Uncharacterized protein. (154 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1137 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1160 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (980 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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