STRINGSTRING
CDKN1A CDKN1A EGLN3 EGLN3 PAK6 PAK6 SOS2 SOS2 RAPGEF1 RAPGEF1 ARNT ARNT CREBBP CREBBP TGFA TGFA EPAS1 EPAS1 SOS1 SOS1 CRKL CRKL EGLN1 EGLN1 VHL VHL PAK2 PAK2 TFE3 TFE3 HGF HGF MET MET GRB2 GRB2 EP300 EP300 RAF1 RAF1 GAB1 GAB1 CDC42 CDC42 MAP2K2 MAP2K2 ARAF ARAF TGFB1 TGFB1 PAK1 PAK1 TGFB3 TGFB3 ARNT2 ARNT2 CRK CRK TGFB2 TGFB2 RAP1B RAP1B PRCC PRCC BAD BAD NRAS NRAS AKT2 AKT2 FH FH HIF1A HIF1A AKT1 AKT1 RAP1A RAP1A HRAS HRAS RBX1 RBX1 PIK3CB PIK3CB PIK3CA PIK3CA LOC100511937 LOC100511937 MAP2K1 MAP2K1 PAK3 PAK3 MAPK3 MAPK3 PTPN11 PTPN11 EGLN2 EGLN2 FLCN FLCN PAK4 PAK4 ELOC ELOC PAK5 PAK5 ELOB ELOB AKT3 AKT3 CUL2 CUL2 MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
PAK6Non-specific serine/threonine protein kinase. (709 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1093 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X3. (790 aa)
CREBBPCREB-binding protein isoform a. (2440 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa)
EPAS1Uncharacterized protein. (870 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
EGLN1Uncharacterized protein. (427 aa)
VHLVon Hippel-Lindau disease tumor suppressor isoform 1. (205 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
EP300E1A binding protein p300. (2420 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa)
GAB1GRB2 associated binding protein 1. (723 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ARAFSerine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity). (609 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (892 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
RAP1BRAP1B, member of RAS oncogene family. (184 aa)
PRCCProline rich mitotic checkpoint control factor. (491 aa)
BADBCL2 associated agonist of cell death. (209 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
FHFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PAK3Non-specific serine/threonine protein kinase. (592 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
EGLN2Uncharacterized protein. (257 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (611 aa)
PAK4Non-specific serine/threonine protein kinase. (591 aa)
ELOCElongin C; Belongs to the SKP1 family. (139 aa)
PAK5Non-specific serine/threonine protein kinase. (744 aa)
ELOBElongin B. (140 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
CUL2Cullin 2; Belongs to the cullin family. (746 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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