STRINGSTRING
RXRB RXRB CDKN1A CDKN1A NFKBIA NFKBIA CCNE1 CCNE1 BAX BAX CASP9 CASP9 LAMA3 LAMA3 LAMA4 LAMA4 CDKN2B CDKN2B TRAF1 TRAF1 LAMC3 LAMC3 TRAF2 TRAF2 CCNE2 CCNE2 IKBKB IKBKB E2F1 E2F1 RB1 RB1 COL4A2 COL4A2 PTEN PTEN CHUK CHUK COL4A6 COL4A6 RELA RELA POLK POLK LAMB1 LAMB1 LAMC2 LAMC2 LAMB3 LAMB3 FN1 FN1 COL4A3 COL4A3 CYCS CYCS SKP2 SKP2 ITGA2 ITGA2 CDK4 CDK4 LOC100519295 LOC100519295 CKS2 CKS2 GADD45G GADD45G ITGA3 ITGA3 TRAF5 TRAF5 ITGB1 ITGB1 ITGAV ITGAV ITGA6 ITGA6 BAK1 BAK1 BCL2L1 BCL2L1 E2F2 E2F2 TRAF6 TRAF6 PTGS2 PTGS2 GADD45B GADD45B LAMC1 LAMC1 LAMA2-2 LAMA2-2 XIAP XIAP TRAF4 TRAF4 DDB2 DDB2 APAF1 APAF1 LAMA1 LAMA1 TRAF3 TRAF3 CDKN1B CDKN1B AKT2 AKT2 COL4A5 COL4A5 NFKB1 NFKB1 LAMB2 LAMB2 IKBKG IKBKG COL4A4 COL4A4 CASP3 CASP3 BIRC3 BIRC3 MAX MAX TP53 TP53 AKT1 AKT1 LAMB4 LAMB4 PIK3CB PIK3CB PIK3CA PIK3CA LOC100511937 LOC100511937 RXRG RXRG PTK2 PTK2 GADD45A GADD45A E2F3 E2F3 NOS2 NOS2 CCND1 CCND1 COL4A1 COL4A1 RXRA RXRA AKT3 AKT3 BIRC7-2 BIRC7-2 MYC MYC ZBTB17 ZBTB17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RXRBRetinoid X receptor beta. (536 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (438 aa)
LAMA3Laminin subunit alpha 3. (3345 aa)
LAMA4Laminin subunit alpha 4. (1815 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (131 aa)
TRAF1TNF receptor-associated factor. (415 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
IKBKBInhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa)
E2F1E2F transcription factor 1. (435 aa)
RB1RB transcriptional corepressor 1. (938 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
PTENUncharacterized protein. (576 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
COL4A6Collagen type IV alpha 6 chain. (1547 aa)
RELATranscription factor p65 isoform 1. (573 aa)
POLKDNA polymerase kappa. (870 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
LAMC2Laminin subunit gamma-2 isoform a. (1191 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
FN1Fibronectin 1. (2462 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SKP2S-phase kinase-associated protein 2 isoform 1. (436 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1178 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa)
LOC100519295Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
GADD45GGrowth arrest and DNA-damage-inducible gamma protein. (159 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
BAK1Uncharacterized protein. (266 aa)
BCL2L1Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
E2F2E2F transcription factor 2. (437 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
GADD45BGrowth arrest and DNA-damage-inducible, beta. (160 aa)
LAMC1Uncharacterized protein. (1607 aa)
LAMA2-2Uncharacterized protein. (921 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
TRAF4TNF receptor-associated factor. (470 aa)
DDB2DNA damage-binding protein 2 isoform WT. (448 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
LAMA1Laminin subunit alpha 1. (3079 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
CDKN1Bp27Kip1. (198 aa)
AKT2Non-specific serine/threonine protein kinase. (525 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
NFKB1Uncharacterized protein. (898 aa)
LAMB2Laminin subunit beta-2. (1881 aa)
IKBKGNF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] (451 aa)
COL4A4Collagen type IV alpha 4 chain. (1691 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
MAXMYC associated factor X. (253 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
AKT1Non-specific serine/threonine protein kinase. (785 aa)
LAMB4Uncharacterized protein. (719 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC100511937Uncharacterized protein. (532 aa)
RXRGRetinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (463 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform 1. (184 aa)
E2F3E2F transcription factor 3. (466 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1195 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
COL4A1Collagen IV NC1 domain-containing protein. (461 aa)
RXRARetinoid X receptor alpha. (701 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa)
BIRC7-2Uncharacterized protein. (428 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
ZBTB17Zinc finger and BTB domain containing 17. (824 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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