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| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | SLC44A5 | Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (723 aa) |
| | SLC22A3 | Solute carrier family 22 member 3. (558 aa) |
| | SLC22A2 | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as [...] (554 aa) |
| | PLA2G4F | Phospholipase A2. (852 aa) |
| | PLA2G4D | Phospholipase A2. (812 aa) |
| | JMJD7 | Phospholipase A2. (780 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1379 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa) |
| | WASF3 | Wiskott-Aldrich syndrome protein family member 3 isoform X1. (498 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (411 aa) |
| | DGKK | Diacylglycerol kinase. (1266 aa) |
| | CHKA | Choline kinase alpha. (565 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa) |
| | DGKD | Diacylglycerol kinase. (1244 aa) |
| | PLPP1 | Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...] (290 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa) |
| | DGKE | Diacylglycerol kinase. (566 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | EIF4EBP1 | Uncharacterized protein. (182 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa) |
| | WASF2 | Wiskott-Aldrich syndrome protein family member 2 isoform 2. (498 aa) |
| | DGKG | Diacylglycerol kinase. (791 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa) |
| | SLC44A1 | Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (665 aa) |
| | PCYT1B | Phosphate cytidylyltransferase 1, choline, beta. (368 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (473 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase. (526 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (668 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | SP1 | Transcription factor Sp1 isoform a. (786 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | DGKZ | Diacylglycerol kinase. (1144 aa) |
| | SLC22A1 | Solute carrier family 22 member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1- methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1- methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N- methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA recepto [...] (555 aa) |
| | SLC22A4 | Solute carrier family 22 member 4. (553 aa) |
| | DGKI | Diacylglycerol kinase. (1110 aa) |
| | DGKA | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (785 aa) |
| | WASF1 | WH2 domain-containing protein. (559 aa) |
| | NRAS | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (525 aa) |
| | RAC3 | Rac family small GTPase 3. (192 aa) |
| | PIP5K1C | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5. (702 aa) |
| | DGKH | Diacylglycerol kinase. (1222 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa) |
| | WAS | WASP actin nucleation promoting factor. (500 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha isoform 1. (824 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (785 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | DGKB | Diacylglycerol kinase. (802 aa) |
| | GPCPD1 | Glycerophosphocholine phosphodiesterase GPCPD1. (672 aa) |
| | CHPT1 | Choline phosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (406 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | LOC100511937 | Uncharacterized protein. (532 aa) |
| | PLA2G4E | Phospholipase A2. (872 aa) |
| | TSC2 | TSC complex subunit 2. (1836 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) |
| | PLA2G4A | Phospholipase A2. (758 aa) |
| | LYPLA1 | Lysophospholipase 1. (303 aa) |
| | PCYT1A | Phosphate cytidylyltransferase 1, choline, alpha. (468 aa) |
| | DGKQ | Diacylglycerol kinase. (987 aa) |
| | PLPP2 | Phospholipid phosphatase 2. (368 aa) |
| | PIP5K1B | Phosphatidylinositol-4-phosphate 5-kinase type 1 beta. (558 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | SLC44A2 | Choline transporter-like protein 2; Choline transporter; Belongs to the CTL (choline transporter-like) family. (715 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | PLPP3 | acidPPc domain-containing protein. (369 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa) |
| | RAC2 | Rac family small GTPase 2. (217 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (440 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (500 aa) |
| | TSC1 | TSC complex subunit 1. (1166 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (568 aa) |
| | RHEB | Uncharacterized protein. (220 aa) |
| | SLC44A4 | Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (By similarity). (715 aa) |
