STRINGSTRING
HLA-DRA HLA-DRA HLA-DOB HLA-DOB SLA-DMB SLA-DMB SLA-DOA SLA-DOA CASP9 CASP9 FYN FYN ITGAL ITGAL CD80 CD80 EIF4G2 EIF4G2 CYCS CYCS SGCD SGCD CD40LG CD40LG LOC100519295 LOC100519295 CASP8 CASP8 CD86 CD86 ICAM1 ICAM1 SLA-DMA SLA-DMA CAV1 CAV1 CD55 CD55 CXADR CXADR ACTB ACTB LAMA2-2 LAMA2-2 SGCA SGCA ACTG1 ACTG1 LAMA1 LAMA1 ITGB2 ITGB2 RAC3 RAC3 BID BID CASP3 CASP3 PRF1 PRF1 CD40 CD40 EIF4G1 EIF4G1 ABL1 ABL1 DAG1 DAG1 TRAV16 TRAV16 CCND1 CCND1 SLA-DQB1 SLA-DQB1 DMD DMD SGCG SGCG A0A5G2R5H2_PIG A0A5G2R5H2_PIG RAC2 RAC2 MYH7 MYH7 CD28 CD28 LOC110261595 LOC110261595
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (252 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain. (277 aa)
SLA-DMBMajor histocompatibility complex, class II, DM beta. (272 aa)
SLA-DOAIg-like domain-containing protein; Belongs to the MHC class II family. (360 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (438 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1235 aa)
CD80CD80 molecule. (297 aa)
EIF4G2Eukaryotic translation initiation factor 4 gamma 2. (949 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SGCDSarcoglycan delta. (290 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa)
LOC100519295Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
CASP8Caspase-8 isoform X2; Belongs to the peptidase C14A family. (486 aa)
CD86T-lymphocyte activation antigen CD86 isoform 1. (337 aa)
ICAM1Intercellular adhesion molecule 1. (537 aa)
SLA-DMAIg-like domain-containing protein; Belongs to the MHC class II family. (290 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
CD55Uncharacterized protein. (609 aa)
CXADRUncharacterized protein. (419 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
LAMA2-2Uncharacterized protein. (921 aa)
SGCASarcoglycan alpha. (387 aa)
ACTG1Actin gamma 1. (381 aa)
LAMA1Laminin subunit alpha 1. (3079 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (903 aa)
RAC3Rac family small GTPase 3. (192 aa)
BIDBH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). (205 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
PRF1Perforin 1. (555 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1613 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (912 aa)
TRAV16T cell receptor alpha variable 16. (166 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
SLA-DQB1SLA class II histocompatibility antigen, DQ haplotype C beta chain. (271 aa)
DMDDystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. (3679 aa)
SGCGUncharacterized protein. (406 aa)
A0A5G2R5H2_PIGUncharacterized protein. (261 aa)
RAC2Rac family small GTPase 2. (217 aa)
MYH7Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2052 aa)
CD28IGv domain-containing protein. (222 aa)
LOC110261595Ig-like domain-containing protein. (290 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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