(43 nodes) Malaria network (Camelus dromedarius)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VCAM1	Vascular cell adhesion protein 1. (733 aa)
	GYPC	Glycophorin C. (101 aa)
	LOC105097953	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. (147 aa)
	THBS1	Thrombospondin-1. (1170 aa)
	TGFB3	Transforming growth factor beta-3 proprotein. (456 aa)
	MET	Hepatocyte growth factor receptor. (1381 aa)
	IL12A	Interleukin-12 subunit alpha. (258 aa)
	SDC1	Syndecan-1. (310 aa)
	CSF3	Granulocyte colony-stimulating factor. (203 aa)
	THBS3	Thrombospondin-3. (952 aa)
	ICAM1	Intercellular adhesion molecule 1. (535 aa)
	KLRB1-2	Killer cell lectin-like receptor subfamily B member 1 isoform X1. (229 aa)
	IL6	Interleukin-6. (211 aa)
	CR1	Complement receptor type 1. (574 aa)
	LOC105098414	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues. (142 aa)
	KLRK1	NKG2-D type II integral membrane protein. (214 aa)
	COMP	Cartilage oligomeric matrix protein. (756 aa)
	IL10	Interleukin-10. (178 aa)
	ITGAL	Integrin alpha-L. (1168 aa)
	ACKR1	Atypical chemokine receptor 1. (327 aa)
	CD40LG	CD40 ligand. (261 aa)
	IL1B	Interleukin-1 beta. (267 aa)
	TLR4	Toll-like receptor 4. (841 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	TGFB1	Transforming growth factor beta-1 proprotein. (390 aa)
	TGFB2	Transforming growth factor beta-2 proprotein. (442 aa)
	LRP1	Prolow-density lipoprotein receptor-related protein 1. (4546 aa)
	MYD88	Myeloid differentiation primary response protein MyD88. (317 aa)
	THBS4	Thrombospondin-4. (961 aa)
	CCL2	C-C motif chemokine 2. (99 aa)
	THBS2	Thrombospondin-2. (1176 aa)
	ENSCDRP00005027847	Platelet glycoprotein 4. (221 aa)
	ENSCDRP00005027865	Platelet glycoprotein 4-like. (94 aa)
	HGF	Hepatocyte growth factor. (728 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5. (298 aa)
	CXCL8	Interleukin-8. (101 aa)
	TNF	Tumor necrosis factor. (233 aa)
	PECAM1	Platelet endothelial cell adhesion molecule. (826 aa)
	CD81	CD81 antigen. (236 aa)
	SDC2	Syndecan-2. (202 aa)
	KLRB1	Killer cell lectin-like receptor subfamily B member 1. (225 aa)
	ITGB2	Integrin beta-2. (826 aa)
	IL18	Interleukin-18 isoform X1. (225 aa)

Your Current Organism:

Camelus dromedarius

NCBI taxonomy Id: 9838
Other names: Arabian camel, C. dromedarius, camel, dromedaries, dromedary, dromedary camel, one-humped camel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR1	CCL2	ENSCDRP00005014930	ENSCDRP00005027219	Atypical chemokine receptor 1.	C-C motif chemokine 2.	0.711
ACKR1	CXCL8	ENSCDRP00005014930	ENSCDRP00005029228	Atypical chemokine receptor 1.	Interleukin-8.	0.926
CCL2	ACKR1	ENSCDRP00005027219	ENSCDRP00005014930	C-C motif chemokine 2.	Atypical chemokine receptor 1.	0.711
CCL2	CD40	ENSCDRP00005027219	ENSCDRP00005028795	C-C motif chemokine 2.	Tumor necrosis factor receptor superfamily member 5.	0.671
CCL2	CD40LG	ENSCDRP00005027219	ENSCDRP00005015315	C-C motif chemokine 2.	CD40 ligand.	0.475
CCL2	CSF3	ENSCDRP00005027219	ENSCDRP00005008559	C-C motif chemokine 2.	Granulocyte colony-stimulating factor.	0.654
CCL2	CXCL8	ENSCDRP00005027219	ENSCDRP00005029228	C-C motif chemokine 2.	Interleukin-8.	0.521
CCL2	ICAM1	ENSCDRP00005027219	ENSCDRP00005009336	C-C motif chemokine 2.	Intercellular adhesion molecule 1.	0.779
CCL2	IFNG	ENSCDRP00005027219	ENSCDRP00005019497	C-C motif chemokine 2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.786
CCL2	IL10	ENSCDRP00005027219	ENSCDRP00005013800	C-C motif chemokine 2.	Interleukin-10.	0.866
CCL2	IL18	ENSCDRP00005027219	ENSCDRP00005032855	C-C motif chemokine 2.	Interleukin-18 isoform X1.	0.714
CCL2	IL1B	ENSCDRP00005027219	ENSCDRP00005016149	C-C motif chemokine 2.	Interleukin-1 beta.	0.824
CCL2	IL6	ENSCDRP00005027219	ENSCDRP00005009916	C-C motif chemokine 2.	Interleukin-6.	0.917
CCL2	ITGB2	ENSCDRP00005027219	ENSCDRP00005032127	C-C motif chemokine 2.	Integrin beta-2.	0.531
CCL2	KLRB1	ENSCDRP00005027219	ENSCDRP00005031596	C-C motif chemokine 2.	Killer cell lectin-like receptor subfamily B member 1.	0.466
CCL2	KLRB1-2	ENSCDRP00005027219	ENSCDRP00005009739	C-C motif chemokine 2.	Killer cell lectin-like receptor subfamily B member 1 isoform X1.	0.466
CCL2	MYD88	ENSCDRP00005027219	ENSCDRP00005025768	C-C motif chemokine 2.	Myeloid differentiation primary response protein MyD88.	0.537
CCL2	PECAM1	ENSCDRP00005027219	ENSCDRP00005030479	C-C motif chemokine 2.	Platelet endothelial cell adhesion molecule.	0.557
CCL2	TGFB1	ENSCDRP00005027219	ENSCDRP00005023368	C-C motif chemokine 2.	Transforming growth factor beta-1 proprotein.	0.537
CCL2	TLR4	ENSCDRP00005027219	ENSCDRP00005018549	C-C motif chemokine 2.	Toll-like receptor 4.	0.628