STRINGSTRING
RGE_00660 RGE_00660 ilvE ilvE RGE_02820 RGE_02820 leuA leuA ldh ldh leuC leuC leuD leuD leuB leuB ilvD ilvD RGE_20970 RGE_20970 ppdK ppdK pyc pyc RGE_22610 RGE_22610 ldh-2 ldh-2 leuA-2 leuA-2 ilvC ilvC ilvH ilvH ilvI ilvI porC porC porA porA porB porB porD porD RGE_32390 RGE_32390 RGE_32600 RGE_32600 dld dld lldD lldD lldA lldA RGE_37010 RGE_37010 yeaU yeaU nifV nifV maeB-2 maeB-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RGE_00660Putative oxidoreductase. (469 aa)
ilvEBranched-chain amino acid aminotransferase IlvE; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
RGE_02820Pyruvate ferredoxin/flavodoxin oxidoreductase. (1188 aa)
leuA2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (558 aa)
ldhL-lactate dehydrogenase Ldh; Belongs to the LDH/MDH superfamily. (308 aa)
leuC3-isopropylmalate dehydratase large LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (484 aa)
leuD3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa)
leuB3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
ilvDDihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (619 aa)
RGE_20970Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (1665 aa)
ppdKPyruvate phosphate dikinase PpdK; Belongs to the PEP-utilizing enzyme family. (907 aa)
pycPyruvate carboxylase Pyc; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1162 aa)
RGE_22610Putative pyruvate kinase. (619 aa)
ldh-2L-lactate dehydrogenase Ldh; Catalyzes the conversion of lactate to pyruvate. (303 aa)
leuA-22-isopropylmalate synthase,LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (513 aa)
ilvCKetol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
ilvHProtein synonym:acetohydroxy-acid synthase small subunit. (163 aa)
ilvIProtein synonym:acetolactate synthase I/II/III large subunit. (590 aa)
porCPyruvate ferredoxin oxidoreductase gamma subunit PorC. (193 aa)
porAPyruvate ferredoxin oxidoreductase alpha subunit PorA. (417 aa)
porBPyruvate ferredoxin oxidoreductase beta subunit PorB. (302 aa)
porDPutative pyruvate ferredoxin oxidoreductase delta subunit PorD. (541 aa)
RGE_32390Protein synonym:acetohydroxy-acid synthase large subunit; Belongs to the TPP enzyme family. (566 aa)
RGE_32600Aminotransferase. (410 aa)
dldD-lactate dehydrogenase Dld; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (581 aa)
lldDL-lactate dehydrogenase cytochrome LldD; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (379 aa)
lldAL-lactate dehydrogenase LldA. (384 aa)
RGE_37010Protein synonym:acetohydroxy-acid synthase large subunit; Belongs to the TPP enzyme family. (584 aa)
yeaUTartrate dehydrogenase YeaU. (359 aa)
nifVHomocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (386 aa)
maeB-2Malate dehydrogenase MaeB. (764 aa)
Your Current Organism:
Rubrivivax gelatinosus
NCBI taxonomy Id: 983917
Other names: R. gelatinosus IL144, Rubrivivax gelatinosus IL144, Rubrivivax gelatinosus str. IL144, Rubrivivax gelatinosus strain IL144
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.