(24 nodes) Nervous system development network (Drechmeria coniospora)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DCS_03781	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (982 aa)
	DCS_02611	Homeobox domain-containing protein. (613 aa)
	DCS_02367	Uncharacterized protein. (293 aa)
	DCS_01885	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (356 aa)
	DCS_01827	MAP kinase kinase EMK1. (541 aa)
	DCS_01642	Uncharacterized protein. (155 aa)
	DCS_01282	PH domain-containing protein. (430 aa)
	DCS_01165	Putative MAP kinase kinase. (564 aa)
	DCS_00977	RacA. (150 aa)
	DCS_00919	WH1 domain-containing protein. (681 aa)
	DCS_00853	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (233 aa)
	DCS_00463	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (719 aa)
	DCS_00464	Rad60-SLD_2 domain-containing protein. (275 aa)
	DCS_04905	Protein kinase domain-containing protein. (620 aa)
	DCS_04615	Putative Cutinase transcription factor 1 alpha. (778 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (941 aa)
	DCS_04180	Adaptor protein complex AP-2, medium chain; Belongs to the adaptor complexes medium subunit family. (560 aa)
	DCS_04131	Amidohydro-rel domain-containing protein. (467 aa)
	DCS_03941	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
	DCS_07734	Cofilin; Belongs to the actin-binding proteins ADF family. (206 aa)
	DCS_06712	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (796 aa)
	DCS_06036	Allantoinase. (504 aa)
	DCS_06005	Adenine deaminase. (383 aa)
	DCS_05968	Uncharacterized protein. (773 aa)

Your Current Organism:

Drechmeria coniospora

NCBI taxonomy Id: 98403
Other names: CBS 615.82, D. coniospora, Meria coniospora

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCS_00463	DCS_00853	A0A151GQG3	A0A151GRI9	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.838
DCS_00463	DCS_00977	A0A151GQG3	A0A151GRY2	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	RacA.	0.598
DCS_00463	DCS_01885	A0A151GQG3	A0A151GUH2	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.554
DCS_00463	DCS_03781	A0A151GQG3	A0A151GI28	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.970
DCS_00463	DCS_03941	A0A151GQG3	A0A151GII8	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.931
DCS_00463	DCS_04180	A0A151GQG3	A0A151GJ70	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Adaptor protein complex AP-2, medium chain; Belongs to the adaptor complexes medium subunit family.	0.976
DCS_00464	DCS_00853	A0A151GQD5	A0A151GRI9	Rad60-SLD_2 domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.838
DCS_00464	DCS_00977	A0A151GQD5	A0A151GRY2	Rad60-SLD_2 domain-containing protein.	RacA.	0.598
DCS_00464	DCS_01885	A0A151GQD5	A0A151GUH2	Rad60-SLD_2 domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.554
DCS_00464	DCS_03781	A0A151GQD5	A0A151GI28	Rad60-SLD_2 domain-containing protein.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.898
DCS_00464	DCS_03941	A0A151GQD5	A0A151GII8	Rad60-SLD_2 domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.931
DCS_00464	DCS_04180	A0A151GQD5	A0A151GJ70	Rad60-SLD_2 domain-containing protein.	Adaptor protein complex AP-2, medium chain; Belongs to the adaptor complexes medium subunit family.	0.959
DCS_00853	DCS_00463	A0A151GRI9	A0A151GQG3	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.838
DCS_00853	DCS_00464	A0A151GRI9	A0A151GQD5	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	Rad60-SLD_2 domain-containing protein.	0.838
DCS_00853	DCS_00919	A0A151GRI9	A0A151GRP9	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	WH1 domain-containing protein.	0.703
DCS_00853	DCS_00977	A0A151GRI9	A0A151GRY2	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	RacA.	0.510
DCS_00853	DCS_01885	A0A151GRI9	A0A151GUH2	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.636
DCS_00853	DCS_03781	A0A151GRI9	A0A151GI28	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.892
DCS_00853	DCS_03941	A0A151GRI9	A0A151GII8	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.998
DCS_00853	DCS_04180	A0A151GRI9	A0A151GJ70	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	Adaptor protein complex AP-2, medium chain; Belongs to the adaptor complexes medium subunit family.	0.928