(26 nodes) Terpenoid backbone biosynthesis network (Drechmeria coniospora)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Predicted Interactions

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Your Input:
	DCS_01580	Geranylgeranyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (442 aa)
	DCS_01454	Peptidase_M48 domain-containing protein. (383 aa)
	DCS_01265	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (278 aa)
	DCS_00453	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (446 aa)
	DCS_00475	Isopentenyl-diphosphate delta-isomerase. (257 aa)
	DCS_00445	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (508 aa)
	DCS_05526	Diphosphomevalonate decarboxylase. (873 aa)
	DCS_05342	Mitochondrial outer membrane 72K protein. (620 aa)
	DCS_05129	Solute carrier family 35 member F1. (449 aa)
	DCS_05120	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (485 aa)
	DCS_04983	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1071 aa)
	DCS_04609	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	DCS_04249	Uncharacterized protein. (510 aa)
	DCS_04296	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1180 aa)
	DCS_04272	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (484 aa)
	DCS_07995	Di-trans, poly-cis-decaprenylcistransferase. (331 aa)
	DCS_02676	Farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family. (347 aa)
	DCS_02204	Zinc finger domain-containing protein. (499 aa)
	DCS_06072	Decaprenyl-diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (450 aa)
	DCS_06817	Prenylcysteine lyase. (564 aa)
	DCS_06852	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (462 aa)
	DCS_06961	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (506 aa)
	DCS_07646	Alkyl transferase; Belongs to the UPP synthase family. (364 aa)
	DCS_01700	Prenyl transferase; Belongs to the FPP/GGPP synthase family. (348 aa)
	DCS_03276	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (767 aa)
	DCS_03054	Putative CAAX prenyl protease 2. (304 aa)

Your Current Organism:

Drechmeria coniospora

NCBI taxonomy Id: 98403
Other names: CBS 615.82, D. coniospora, Meria coniospora

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCS_00445	DCS_00475	A0A151GQC0	A0A151GQF2	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Isopentenyl-diphosphate delta-isomerase.	0.418
DCS_00445	DCS_04296	A0A151GQC0	A0A151GJM6	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.497
DCS_00445	DCS_04609	A0A151GQC0	A0A151GKI0	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.891
DCS_00445	DCS_05120	A0A151GQC0	A0A151GLX7	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.747
DCS_00445	DCS_05526	A0A151GQC0	A0A151GN43	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase.	0.627
DCS_00445	DCS_06852	A0A151GQC0	A0A151GCV6	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.991
DCS_00453	DCS_00475	A0A151GQF3	A0A151GQF2	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Isopentenyl-diphosphate delta-isomerase.	0.523
DCS_00453	DCS_02676	A0A151GQF3	A0A151GWR0	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family.	0.506
DCS_00453	DCS_04296	A0A151GQF3	A0A151GJM6	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.672
DCS_00453	DCS_04609	A0A151GQF3	A0A151GKI0	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.525
DCS_00453	DCS_05120	A0A151GQF3	A0A151GLX7	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.943
DCS_00453	DCS_05526	A0A151GQF3	A0A151GN43	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Diphosphomevalonate decarboxylase.	0.895
DCS_00453	DCS_06072	A0A151GQF3	A0A151GAL0	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Decaprenyl-diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family.	0.426
DCS_00453	DCS_06852	A0A151GQF3	A0A151GCV6	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.536
DCS_00475	DCS_00445	A0A151GQF2	A0A151GQC0	Isopentenyl-diphosphate delta-isomerase.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.418
DCS_00475	DCS_00453	A0A151GQF2	A0A151GQF3	Isopentenyl-diphosphate delta-isomerase.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.523
DCS_00475	DCS_01580	A0A151GQF2	A0A151GTQ8	Isopentenyl-diphosphate delta-isomerase.	Geranylgeranyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family.	0.931
DCS_00475	DCS_01700	A0A151GQF2	A0A151GU31	Isopentenyl-diphosphate delta-isomerase.	Prenyl transferase; Belongs to the FPP/GGPP synthase family.	0.759
DCS_00475	DCS_02676	A0A151GQF2	A0A151GWR0	Isopentenyl-diphosphate delta-isomerase.	Farnesyl pyrophosphate synthetase; Belongs to the FPP/GGPP synthase family.	0.955
DCS_00475	DCS_04296	A0A151GQF2	A0A151GJM6	Isopentenyl-diphosphate delta-isomerase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.750