STRINGSTRING
glyA glyA SGRA_0031 SGRA_0031 thyA thyA SGRA_0122 SGRA_0122 gcvT gcvT ahcY ahcY sdaA sdaA metF metF sdaA-2 sdaA-2 thrB thrB ilvE ilvE SGRA_2550 SGRA_2550 folD folD metH metH gcvH gcvH metC metC folA folA gcvP gcvP fmt fmt
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene fusions
gene co-occurrence
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (435 aa)
SGRA_0031COG3643 Glutamate formiminotransferase. (561 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
SGRA_0122COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (435 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
ahcYS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (438 aa)
sdaACOG1171 Threonine dehydratase. (301 aa)
metFCOG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
sdaA-2COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (482 aa)
thrBCOG0083 Homoserine kinase. (303 aa)
ilvECOG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (362 aa)
SGRA_2550Cystathionine beta-synthase; COG0031 Cysteine synthase. (455 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1225 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
metCCOG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (379 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (175 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (307 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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