7 items (Saprospira grandis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	SGRA_0638	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (324 aa)
	kbl	2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa)
	SGRA_0640	Hypothetical protein. (44 aa)
	bioF	8-amino-7-oxononanoate synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes. (376 aa)
	bioD	Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (213 aa)
	bioB	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (330 aa)
	bioA	COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa)

Your Current Organism:

Saprospira grandis

NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SGRA_0638	SGRA_0640	SGRA_0638	SGRA_0640	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	Hypothetical protein.	0.639
SGRA_0638	kbl	SGRA_0638	SGRA_0639	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.	0.930
SGRA_0640	SGRA_0638	SGRA_0640	SGRA_0638	Hypothetical protein.	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.639
SGRA_0640	kbl	SGRA_0640	SGRA_0639	Hypothetical protein.	2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.	0.639
bioA	bioB	SGRA_3899	SGRA_3731	COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.995
bioA	bioD	SGRA_3899	SGRA_1647	COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.999
bioA	bioF	SGRA_3899	SGRA_1160	COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	8-amino-7-oxononanoate synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes.	0.991
bioA	kbl	SGRA_3899	SGRA_0639	COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.	0.705
bioB	bioA	SGRA_3731	SGRA_3899	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.995
bioB	bioD	SGRA_3731	SGRA_1647	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.998
bioB	bioF	SGRA_3731	SGRA_1160	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	8-amino-7-oxononanoate synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes.	0.948
bioB	kbl	SGRA_3731	SGRA_0639	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.	0.729
bioD	bioA	SGRA_1647	SGRA_3899	Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.999
bioD	bioB	SGRA_1647	SGRA_3731	Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.998
bioD	bioF	SGRA_1647	SGRA_1160	Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	8-amino-7-oxononanoate synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes.	0.915
bioD	kbl	SGRA_1647	SGRA_0639	Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.	0.727
bioF	bioA	SGRA_1160	SGRA_3899	8-amino-7-oxononanoate synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes.	COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.991
bioF	bioB	SGRA_1160	SGRA_3731	8-amino-7-oxononanoate synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes.	Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.	0.948
bioF	bioD	SGRA_1160	SGRA_1647	8-amino-7-oxononanoate synthase; COG0156 7-keto-8-aminopelargonate synthetase and related enzymes.	Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.	0.915
kbl	SGRA_0638	SGRA_0639	SGRA_0638	2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.	NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases.	0.930