STRINGSTRING
pyrG pyrG murI murI adk adk purA purA add add nrdA nrdA nrdB nrdB udk udk relA relA punA punA SGRA_2329 SGRA_2329 upp upp cdd cdd SGRA_2933 SGRA_2933 dcd dcd surE surE SGRA_3321 SGRA_3321 SGRA_3322 SGRA_3322 SGRA_3396 SGRA_3396 amn amn ndk ndk SGRA_3733 SGRA_3733 mazG mazG tdk tdk guaC guaC dut dut gmk gmk hpt hpt udp udp
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (278 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (422 aa)
addCOG1816 Adenosine deaminase. (431 aa)
nrdARibonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (803 aa)
nrdBRibonucleoside-diphosphate reductase small chain; COG0208 Ribonucleotide reductase, beta subunit. (323 aa)
udkCOG0572 Uridine kinase. (209 aa)
relA(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (765 aa)
punAPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (276 aa)
SGRA_2329Putative deoxyribonucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (195 aa)
uppCOG0035 Uracil phosphoribosyltransferase. (219 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (161 aa)
SGRA_2933Hypothetical protein. (36 aa)
dcdCOG0717 Deoxycytidine deaminase. (178 aa)
surE5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
SGRA_3321COG0402 Cytosine deaminase and related metal-dependent hydrolases. (320 aa)
SGRA_3322Hypothetical protein. (66 aa)
SGRA_33965 nucleotidase deoxy cytosolic type C; COG4502 Uncharacterized protein conserved in bacteria. (149 aa)
amnAMP nucleosidase; COG0775 Nucleoside phosphorylase. (257 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
SGRA_3733COG1428 Deoxynucleoside kinases. (210 aa)
mazGNucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. (254 aa)
tdkCOG1435 Thymidine kinase. (184 aa)
guaCGuanosine 5'-monophosphate oxidoreductase; COG0516 IMP dehydrogenase/GMP reductase. (340 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
hptCOG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa)
udpPhosphorylase family protein; COG2820 Uridine phosphorylase. (288 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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