STRINGSTRING
dnaA dnaA SGRA_0043 SGRA_0043 lon lon SGRA_0113 SGRA_0113 SGRA_0118 SGRA_0118 SGRA_0152 SGRA_0152 SGRA_0177 SGRA_0177 SGRA_0197 SGRA_0197 phoB1 phoB1 cas1 cas1 hsdR hsdR SGRA_0310 SGRA_0310 SGRA_0347 SGRA_0347 SGRA_0380 SGRA_0380 SGRA_0390 SGRA_0390 SGRA_0410 SGRA_0410 recF recF SGRA_0495 SGRA_0495 xerD xerD SGRA_0534 SGRA_0534 gyrA gyrA SGRA_0546 SGRA_0546 SGRA_0580 SGRA_0580 degS degS narL narL dpx dpx rpoE rpoE SGRA_0629 SGRA_0629 rpoE-2 rpoE-2 SGRA_0735 SGRA_0735 priA priA SGRA_0764 SGRA_0764 parB parB SGRA_0769 SGRA_0769 rpoD rpoD nth nth uvrD-2 uvrD-2 asnC asnC rpoE-11 rpoE-11 SGRA_4160 SGRA_4160 ycaJ ycaJ hsdM-3 hsdM-3 hsdS-3 hsdS-3 SGRA_4128 SGRA_4128 smf smf smc smc SGRA_4027 SGRA_4027 SGRA_3957 SGRA_3957 SGRA_3913 SGRA_3913 hsdR-3 hsdR-3 hsdS-2 hsdS-2 hsdM-2 hsdM-2 SGRA_3889 SGRA_3889 SGRA_3882 SGRA_3882 SGRA_3864 SGRA_3864 SGRA_3736 SGRA_3736 SGRA_3694 SGRA_3694 SGRA_3663 SGRA_3663 SGRA_3662 SGRA_3662 SGRA_3658 SGRA_3658 comM comM hsdS hsdS SGRA_3580 SGRA_3580 SGRA_3579 SGRA_3579 SGRA_3570 SGRA_3570 phoB1-2 phoB1-2 sms sms polA polA pilH pilH SGRA_3417 SGRA_3417 hsdM hsdM SGRA_3413 SGRA_3413 hsdR-2 hsdR-2 SGRA_3410 SGRA_3410 hslR hslR SGRA_3372 SGRA_3372 rpoE-10 rpoE-10 holA holA SGRA_3261 SGRA_3261 gyrB gyrB rpoN rpoN recB recB cheY cheY SGRA_3208 SGRA_3208 SGRA_3207 SGRA_3207 SGRA_3173 SGRA_3173 SGRA_3152 SGRA_3152 SGRA_3151 SGRA_3151 recR recR SGRA_3132 SGRA_3132 SGRA_3008 SGRA_3008 ftsK ftsK SGRA_2982 SGRA_2982 SGRA_2981 SGRA_2981 SGRA_2979 SGRA_2979 lrp lrp mutL mutL SGRA_2902 SGRA_2902 troR troR SGRA_2790 SGRA_2790 SGRA_2735 SGRA_2735 dnaB dnaB sprA sprA ruvA ruvA SGRA_2653 SGRA_2653 mutS2 mutS2 xthA xthA ruvB ruvB hupB-2 hupB-2 SGRA_2546 SGRA_2546 SGRA_2540 SGRA_2540 SGRA_2500 SGRA_2500 SGRA_2480 SGRA_2480 rpoE-9 rpoE-9 SGRA_2417 SGRA_2417 SGRA_2416 SGRA_2416 uvrA-2 uvrA-2 rpoE-8 rpoE-8 SGRA_2395 SGRA_2395 pal-3 pal-3 rpoC rpoC rpoB rpoB nusG nusG SGRA_2290 SGRA_2290 SGRA_2288 SGRA_2288 SGRA_2285 SGRA_2285 SGRA_2251 SGRA_2251 ssb ssb SGRA_2172 SGRA_2172 SGRA_2155 SGRA_2155 uvrA uvrA mutS mutS SGRA_2114 SGRA_2114 SGRA_2093 SGRA_2093 greA greA SGRA_2039 SGRA_2039 SGRA_2030 SGRA_2030 recA recA SGRA_2000 SGRA_2000 SGRA_1972 SGRA_1972 SGRA_1917 SGRA_1917 SGRA_1902 SGRA_1902 SGRA_1892 SGRA_1892 dnaN dnaN rpoA rpoA SGRA_1788 SGRA_1788 xerC xerC rpoE-7 rpoE-7 uvrB uvrB SGRA_1751 SGRA_1751 dnaG dnaG SGRA_1732 SGRA_1732 fnr fnr SGRA_1671 SGRA_1671 mfd mfd rpoS rpoS rpoE-6 rpoE-6 rpoE-5 rpoE-5 recQ-2 recQ-2 SGRA_1554 SGRA_1554 SGRA_1541 SGRA_1541 parE parE SGRA_1443 SGRA_1443 SGRA_1411 SGRA_1411 SGRA_1375 SGRA_1375 SGRA_1366 SGRA_1366 SGRA_1355 SGRA_1355 uvrC uvrC SGRA_1322 SGRA_1322 SGRA_1288 SGRA_1288 hupB hupB dnaX dnaX pleC1 pleC1 SGRA_1250 SGRA_1250 SGRA_1246 SGRA_1246 SGRA_1244 SGRA_1244 SGRA_1191 SGRA_1191 SGRA_1184 SGRA_1184 SGRA_1158 SGRA_1158 SGRA_1132 SGRA_1132 rpoE-4 rpoE-4 SGRA_1048 SGRA_1048 rpoE-3 rpoE-3 SGRA_1023 SGRA_1023 recQ recQ SGRA_0911 SGRA_0911 parC parC SGRA_0891 SGRA_0891 mraZ mraZ topA topA SGRA_0830 SGRA_0830
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaAChromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (501 aa)
SGRA_0043Type 4 fimbriae expression regulatory protein pilR; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (549 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (804 aa)
SGRA_0113COG2963 Transposase and inactivated derivatives. (140 aa)
SGRA_0118Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
SGRA_0152Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (101 aa)
SGRA_0177Two component transcriptional regulator, LytTR family protein; COG3279 Response regulator of the LytR/AlgR family. (234 aa)
SGRA_0197RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa)
phoB1COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (237 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (321 aa)
hsdRType I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (936 aa)
SGRA_0310COG1733 Predicted transcriptional regulators. (113 aa)
SGRA_0347COG2963 Transposase and inactivated derivatives. (140 aa)
SGRA_0380Pseudouridine synthase, Rsu; COG3210 Large exoproteins involved in heme utilization or adhesion. (110 aa)
SGRA_0390Response regulator receiver protein. (307 aa)
SGRA_0410Transcriptional regulator, Crp/Fnr family protein; COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases. (149 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (372 aa)
SGRA_0495Two component transcriptional regulator, LytTR family protein; COG3279 Response regulator of the LytR/AlgR family. (239 aa)
xerDTyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (303 aa)
SGRA_0534Transposase, mutator type; Required for the transposition of the insertion element. (362 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (858 aa)
SGRA_0546Putative transcriptional regulator, Crp/Fnr family; COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases. (190 aa)
SGRA_0580Hypothetical protein; COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (153 aa)
degSMulti-sensor signal transduction histidine kinase; COG2202 FOG: PAS/PAC domain. (1047 aa)
narLTwo component transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (219 aa)
dpxPHP domain protein; COG1796 DNA polymerase IV (family X). (556 aa)
rpoERNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (172 aa)
SGRA_0629COG2932 Predicted transcriptional regulator; Belongs to the peptidase S24 family. (241 aa)
rpoE-2RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa)
SGRA_0735Penicillinase repressor; COG3682 Predicted transcriptional regulator. (108 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (839 aa)
SGRA_0764Putative two component, sigma54 specific, transcriptional regulator, Fis family protein; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (421 aa)
parBPutative ParB-like chromosome partitioning protein; COG1475 Predicted transcriptional regulators; Belongs to the ParB family. (359 aa)
SGRA_0769Hypothetical protein. (356 aa)
rpoDRNA polymerase, sigma 70 subunit, RpoD subfamily protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (290 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
uvrD-2COG0210 Superfamily I DNA and RNA helicases. (759 aa)
asnCTranscriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. (160 aa)
rpoE-11COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (201 aa)
SGRA_4160COG2963 Transposase and inactivated derivatives. (140 aa)
ycaJRecombination factor protein RarA; COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase. (424 aa)
hsdM-3COG0286 Type I restriction-modification system methyltransferase subunit. (780 aa)
hsdS-3Type I restriction-modification system; COG0732 Restriction endonuclease S subunits. (430 aa)
SGRA_4128COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (1036 aa)
smfDNA protecting protein DprA; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. (365 aa)
smcChromosome segregation protein smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1173 aa)
SGRA_4027Putative transcriptional regulator; COG2207 AraC-type DNA-binding domain-containing proteins. (292 aa)
SGRA_3957Putative AraC family transcriptional regulator; COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain. (299 aa)
SGRA_3913Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
hsdR-3Type I restriction-modification system, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1070 aa)
hsdS-2COG0732 Restriction endonuclease S subunits. (385 aa)
hsdM-2COG0286 Type I restriction-modification system methyltransferase subunit. (512 aa)
SGRA_3889Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
SGRA_3882COG1510 Predicted transcriptional regulators; Belongs to the GbsR family. (218 aa)
SGRA_3864Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
SGRA_3736Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. (1481 aa)
SGRA_3694Putative lipoprotein. (291 aa)
SGRA_3663Hypothetical protein. (270 aa)
SGRA_3662Hypothetical protein. (278 aa)
SGRA_3658COG3022 Uncharacterized protein conserved in bacteria; Belongs to the UPF0246 family. (250 aa)
comMMg chelatase, subunit chli; COG0606 Predicted ATPase with chaperone activity. (518 aa)
hsdSRestriction modification system DNA specificity domain protein; COG0732 Restriction endonuclease S subunits. (383 aa)
SGRA_3580COG3666 Transposase and inactivated derivatives. (282 aa)
SGRA_3579Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (236 aa)
SGRA_3570ABC-type transporter ATP-binding protein; COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (622 aa)
phoB1-2Two component transcriptional regulator, winged helix family protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (235 aa)
smsDNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (464 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (927 aa)
pilHTwo-component system response regulator; COG0784 FOG: CheY-like receiver. (122 aa)
SGRA_3417Type I restriction modification enzyme protein S; COG0732 Restriction endonuclease S subunits. (364 aa)
hsdMCOG0286 Type I restriction-modification system methyltransferase subunit. (501 aa)
SGRA_3413COG1943 Transposase and inactivated derivatives. (142 aa)
hsdR-2COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (1132 aa)
SGRA_3410COG1555 DNA uptake protein and related DNA-binding proteins. (283 aa)
hslRCOG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). (139 aa)
SGRA_3372Transcriptional regulator; COG2207 AraC-type DNA-binding domain-containing proteins. (303 aa)
rpoE-10RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa)
holACOG1466 DNA polymerase III, delta subunit. (356 aa)
SGRA_3261Transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator. (212 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (658 aa)
rpoNCOG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog. (539 aa)
recBUvrD/REP helicase; COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains). (1091 aa)
cheYChemotaxis response regulator (CheY); COG0784 FOG: CheY-like receiver. (127 aa)
SGRA_3208Two component transcriptional regulator, LuxR family; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (175 aa)
SGRA_3207Transcriptional regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (239 aa)
SGRA_3173Regulatory protein tetr; COG1309 Transcriptional regulator. (202 aa)
SGRA_3152COG3210 Large exoproteins involved in heme utilization or adhesion. (103 aa)
SGRA_3151Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (202 aa)
SGRA_3132Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
SGRA_3008Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
ftsKCOG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins. (850 aa)
SGRA_2982COG1555 DNA uptake protein and related DNA-binding proteins. (689 aa)
SGRA_2981Hypothetical protein. (286 aa)
SGRA_2979Transcriptional regulator, AraC family protein; COG2207 AraC-type DNA-binding domain-containing proteins. (288 aa)
lrpTranscriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. (165 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (622 aa)
SGRA_2902Hypothetical protein. (323 aa)
troRIron dependent repressor; COG1321 Mn-dependent transcriptional regulator. (223 aa)
SGRA_2790Hypothetical protein. (1159 aa)
SGRA_2735Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
dnaBPrimary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (510 aa)
sprAGliding motility protein SprA. (2512 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
SGRA_2653Transcriptional regulator, TetR family protein; COG1309 Transcriptional regulator. (195 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa)
xthAExodeoxyribonuclease III Xth; COG0708 Exonuclease III. (257 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (341 aa)
hupB-2COG0776 Bacterial nucleoid DNA-binding protein; Belongs to the bacterial histone-like protein family. (106 aa)
SGRA_2546DNA-directed RNA polymerase, omega subunit. (113 aa)
SGRA_2540Hypothetical protein. (121 aa)
SGRA_2500Sigma54 specific transcriptional regulator, Fis family protein; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (433 aa)
SGRA_2480COG1309 Transcriptional regulator. (194 aa)
rpoE-9COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa)
SGRA_2417Helix-turn-helix domain protein; COG2932 Predicted transcriptional regulator; Belongs to the peptidase S24 family. (254 aa)
SGRA_2416Transcriptional regulator, XRE family; COG1813 Predicted transcription factor, homolog of eukaryotic MBF1. (105 aa)
uvrA-2UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (930 aa)
rpoE-8RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa)
SGRA_2395ECF subfamily RNA polymerase sigma-24 factor; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa)
pal-3OmpA/MotB domain-containing protein; COG0457 FOG: TPR repeat. (675 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1420 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1276 aa)
nusGNusG antitermination factor; Participates in transcription elongation, termination and antitermination. (180 aa)
SGRA_2290N-6 DNA methylase; COG0286 Type I restriction-modification system methyltransferase subunit. (629 aa)
SGRA_2288ADP-ribosylation/crystallin J1. (393 aa)
SGRA_2285RNA polymerase sigma factor, sigma-70 family protein; COG1191 DNA-directed RNA polymerase specialized sigma subunit. (199 aa)
SGRA_2251DNA mismatch repair protein MutS domain-containing protein; COG0249 Mismatch repair ATPase (MutS family). (589 aa)
ssbCOG0629 Single-stranded DNA-binding protein. (162 aa)
SGRA_2172Hypothetical protein. (1718 aa)
SGRA_2155Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (884 aa)
SGRA_2114Transcriptional regulator, BadM/Rrf2 family protein; COG1959 Predicted transcriptional regulator. (145 aa)
SGRA_2093Two component transcriptional regulator, LuxR family protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (289 aa)
greATranscription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (160 aa)
SGRA_2039Hypothetical protein; Belongs to the SOS response-associated peptidase family. (216 aa)
SGRA_2030Secreted protein. (180 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (372 aa)
SGRA_2000Hypothetical protein. (356 aa)
SGRA_1972Chromosome segregation ATPase-like protein. (1125 aa)
SGRA_1917Transcriptional regulator, XRE family; COG1396 Predicted transcriptional regulators. (149 aa)
SGRA_1902Hypothetical protein. (421 aa)
SGRA_1892COG2207 AraC-type DNA-binding domain-containing proteins. (296 aa)
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (332 aa)
SGRA_1788Transcriptional regulator, MerR family protein; COG0789 Predicted transcriptional regulators. (294 aa)
xerCIntegrase family protein; COG4974 Site-specific recombinase XerD; Belongs to the 'phage' integrase family. (299 aa)
rpoE-7RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (680 aa)
SGRA_1751Hypothetical protein. (256 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (683 aa)
SGRA_1732RNA polymerase, sigma-E factor; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa)
fnrCRP family transcriptional regulator; COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases. (223 aa)
SGRA_1671Transposase, mutator type; COG3328 Transposase and inactivated derivatives. (398 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1122 aa)
rpoSPutative RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (290 aa)
rpoE-6RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (175 aa)
rpoE-5COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (213 aa)
recQ-2COG0514 Superfamily II DNA helicase. (737 aa)
SGRA_1554Transcriptional regulator; COG2207 AraC-type DNA-binding domain-containing proteins. (281 aa)
SGRA_1541COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (241 aa)
parEDNA topoisomerase IV subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. (616 aa)
SGRA_1443Transcriptional regulator; COG2812 DNA polymerase III, gamma/tau subunits; Belongs to the peptidase S24 family. (280 aa)
SGRA_1411Transposase, mutator type; Required for the transposition of the insertion element. (398 aa)
SGRA_1375RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa)
SGRA_1366Chromosome segregation ATPase-like protein; COG3210 Large exoproteins involved in heme utilization or adhesion. (109 aa)
SGRA_1355Smr protein/MutS2; COG1193 Mismatch repair ATPase (MutS family). (365 aa)
uvrCUvrabc system protein c; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (603 aa)
SGRA_1322COG2963 Transposase and inactivated derivatives. (140 aa)
SGRA_1288Transcriptional regulator, TetR family; COG1309 Transcriptional regulator. (228 aa)
hupBDNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (108 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (593 aa)
pleC1Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. (678 aa)
SGRA_1250Type 4 fimbriae expression regulatory protein PilR; COG3283 Transcriptional regulator of aromatic amino acids metabolism. (300 aa)
SGRA_1246AraC family transcriptional regulator; COG2207 AraC-type DNA-binding domain-containing proteins. (280 aa)
SGRA_1244Hypothetical protein. (237 aa)
SGRA_1191COG2963 Transposase and inactivated derivatives. (140 aa)
SGRA_1184COG2963 Transposase and inactivated derivatives. (140 aa)
SGRA_1158Two component LuxR family transcriptional regulator; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (231 aa)
SGRA_1132Two component, sigma54 specific, Fis family transcriptional regulator; COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain. (534 aa)
rpoE-4RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa)
SGRA_1048Transcriptional regulator, XRE family protein; COG2932 Predicted transcriptional regulator; Belongs to the peptidase S24 family. (246 aa)
rpoE-3RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (152 aa)
SGRA_1023RNA-directed DNA polymerase; COG3344 Retron-type reverse transcriptase. (554 aa)
recQATP-dependent DNA helicase, RecQ family protein; COG0514 Superfamily II DNA helicase. (2930 aa)
SGRA_0911tetR family regulatory protein; COG1309 Transcriptional regulator. (211 aa)
parCCOG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. (839 aa)
SGRA_0891Transposase, is4 family protein; COG3666 Transposase and inactivated derivatives. (554 aa)
mraZMraZ protein; COG2001 Uncharacterized protein conserved in bacteria; Belongs to the MraZ family. (153 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (876 aa)
SGRA_0830Hypothetical protein. (239 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
Server load: low (18%) [HD]