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| | dnaA | Chromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (501 aa) |
| | SGRA_0036 | ABC transporter related protein; COG4152 ABC-type uncharacterized transport system, ATPase component. (299 aa) |
| | SGRA_0043 | Type 4 fimbriae expression regulatory protein pilR; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (549 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (494 aa) |
| | lon | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (804 aa) |
| | SGRA_0111 | Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (412 aa) |
| | SGRA_0114 | COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes. (348 aa) |
| | SGRA_0122 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (435 aa) |
| | groEL | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (546 aa) |
| | groES | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (88 aa) |
| | SGRA_0134 | Hypothetical protein; COG0577 ABC-type antimicrobial peptide transport system, permease component. (413 aa) |
| | SGRA_0138 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (850 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | SGRA_0195 | ABC transporter related protein; COG1136 ABC-type antimicrobial peptide transport system, ATPase component. (233 aa) |
| | SGRA_0207 | Tetratricopeptide repeat domain protein; COG0457 FOG: TPR repeat. (285 aa) |
| | SGRA_0210 | Tetratricopeptide TPR_2; COG0457 FOG: TPR repeat. (282 aa) |
| | SGRA_0212 | Hypothetical protein; COG4637 Predicted ATPase. (946 aa) |
| | SGRA_0217 | CRISPR-associated protein, Csm1 family; COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs). (903 aa) |
| | SGRA_0221 | ABC transporter related protein; COG3842 ABC-type spermidine/putrescine transport systems, ATPase components. (212 aa) |
| | SGRA_0244 | Hypothetical protein; COG1106 Predicted ATPases. (399 aa) |
| | SGRA_0285 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (811 aa) |
| | hsdR | Type I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (936 aa) |
| | SGRA_0300 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (691 aa) |
| | SGRA_0306 | TPR repeat-containing protein; COG1401 GTPase subunit of restriction endonuclease. (825 aa) |
| | lolD | ABC transporter related protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (220 aa) |
| | mrp | ATP-binding protein, Mrp/Nbp35 family; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (364 aa) |
| | SGRA_0380 | Pseudouridine synthase, Rsu; COG3210 Large exoproteins involved in heme utilization or adhesion. (110 aa) |
| | SGRA_0400 | AAA ATPase. (287 aa) |
| | SGRA_0401 | SMC domain protein; COG3950 Predicted ATP-binding protein involved in virulence. (532 aa) |
| | SGRA_0403 | AAA ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (440 aa) |
| | SGRA_0414 | COG0542 ATPases with chaperone activity, ATP-binding subunit. (753 aa) |
| | dacA | Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (256 aa) |
| | recF | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (372 aa) |
| | SGRA_0456 | Hypothetical protein. (591 aa) |
| | SGRA_0468 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (888 aa) |
| | nnrE | Putative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] (517 aa) |
| | SGRA_0498 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (733 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (858 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (361 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa) |
| | SGRA_0560 | Filamentation induced by cAMP protein Fic. (456 aa) |
| | SGRA_0564 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (315 aa) |
| | clpC | ATPase AAA-2 domain protein; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. (847 aa) |
| | SGRA_0580 | Hypothetical protein; COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (153 aa) |
| | SGRA_0590 | Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (400 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | prpE | prpE protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (627 aa) |
| | pilB | COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB. (478 aa) |
| | SGRA_0724 | ABC transporter ATP-binding protein; COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component. (255 aa) |
| | SGRA_0742 | Glutamate-rich protein grpB. (177 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (839 aa) |
| | SGRA_0757 | COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (448 aa) |
| | tilS | Putative cell-cycle protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (444 aa) |
| | SGRA_0764 | Putative two component, sigma54 specific, transcriptional regulator, Fis family protein; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (421 aa) |
| | SGRA_0769 | Hypothetical protein. (356 aa) |
| | SGRA_0798 | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (286 aa) |
| | SGRA_0814 | ATPase-like protein; COG1106 Predicted ATPases. (1555 aa) |
| | SGRA_0832 | COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain. (383 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (247 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (491 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (458 aa) |
| | murC | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (453 aa) |
| | parC | COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. (839 aa) |
| | hscA | Fe-S protein assembly chaperone HscA; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family. (629 aa) |
| | cysS | COG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (556 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (596 aa) |
| | ppnK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa) |
| | SGRA_0947 | ABC transporter, ATP-binding protein; COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components. (240 aa) |
| | htpG | ATP-binding region ATPase domain protein; Molecular chaperone. Has ATPase activity. (619 aa) |
| | recQ | ATP-dependent DNA helicase, RecQ family protein; COG0514 Superfamily II DNA helicase. (2930 aa) |
| | SGRA_1011 | Hypothetical protein. (385 aa) |
| | SGRA_1012 | Hypothetical protein. (311 aa) |
| | SGRA_1025 | ATP-dependent DNA ligase. (1056 aa) |
| | mcrB | ATPase associated with various cellular activities AAA_5; COG1401 GTPase subunit of restriction endonuclease. (549 aa) |
| | SGRA_1082 | Serine/threonine protein kinase; COG2815 Uncharacterized protein conserved in bacteria. (302 aa) |
| | udk | COG0572 Uridine kinase. (209 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (902 aa) |
| | SGRA_1132 | Two component, sigma54 specific, Fis family transcriptional regulator; COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain. (534 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (417 aa) |
| | dnaJ | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (392 aa) |
| | dnaK | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (616 aa) |
| | mvaD | COG3407 Mevalonate pyrophosphate decarboxylase. (347 aa) |
| | SGRA_1218 | ABC transporter related protein; COG1136 ABC-type antimicrobial peptide transport system, ATPase component. (315 aa) |
| | moxR | COG0714 MoxR-like ATPases. (331 aa) |
| | SGRA_1226 | Von Willebrand factor type A; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (333 aa) |
| | SGRA_1227 | Von Willebrand factor type A; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (336 aa) |
| | SGRA_1248 | O-methyltransferase family 2. (231 aa) |
| | SGRA_1250 | Type 4 fimbriae expression regulatory protein PilR; COG3283 Transcriptional regulator of aromatic amino acids metabolism. (300 aa) |
| | SGRA_1255 | Type 4 fimbriae expression regulatory protein PilR; COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain. (608 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (593 aa) |
| | ftsH | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (675 aa) |
| | SGRA_1346 | Hypothetical protein. (1035 aa) |
| | SGRA_1355 | Smr protein/MutS2; COG1193 Mismatch repair ATPase (MutS family). (365 aa) |
| | SGRA_1358 | Hypothetical protein. (310 aa) |
| | SGRA_1366 | Chromosome segregation ATPase-like protein; COG3210 Large exoproteins involved in heme utilization or adhesion. (109 aa) |
| | SGRA_1372 | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (185 aa) |
| | SGRA_1384 | COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (646 aa) |
| | lysS | COG1190 Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (545 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1123 aa) |
| | parE | DNA topoisomerase IV subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. (616 aa) |
| | phoR-2 | Histidine kinase; COG0642 Signal transduction histidine kinase. (500 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa) |
| | recQ-2 | COG0514 Superfamily II DNA helicase. (737 aa) |
| | SGRA_1576 | WbqC-like family protein. (229 aa) |
| | SGRA_1592 | COG0515 Serine/threonine protein kinase. (349 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa) |
| | SGRA_1604 | Hypothetical protein; COG0577 ABC-type antimicrobial peptide transport system, permease component. (438 aa) |
| | recN | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (552 aa) |
| | SGRA_1638 | ABC transporter related protein; COG1131 ABC-type multidrug transport system, ATPase component. (210 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (213 aa) |
| | glnS | COG0008 Glutamyl- and glutaminyl-tRNA synthetases. (577 aa) |
| | moxR-2 | ATPase associated with various cellular activities AAA_3; COG0714 MoxR-like ATPases. (320 aa) |
| | serS | COG0172 Seryl-tRNA synthetase. (427 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (589 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1122 aa) |
| | phoH | Phoh family protein; COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase. (339 aa) |
| | SGRA_1715 | ATP-binding protein; COG1106 Predicted ATPases. (434 aa) |
| | spoVK | Stage V sporulation protein K; COG0464 ATPases of the AAA+ class. (875 aa) |
| | SGRA_1729 | Cobyrinic acid ac-diamide synthase; COG1192 ATPases involved in chromosome partitioning. (280 aa) |
| | SGRA_1742 | ABC transporter related protein; COG1132 ABC-type multidrug transport system, ATPase and permease components. (605 aa) |
| | uvrB | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (680 aa) |
| | SGRA_1804 | COG0818 Diacylglycerol kinase. (125 aa) |
| | SGRA_1813 | AAA ATPase central domain protein; COG0464 ATPases of the AAA+ class. (462 aa) |
| | secA | Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (1110 aa) |
| | SGRA_1902 | Hypothetical protein. (421 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (901 aa) |
| | lptB | ABC transporter related protein; COG1137 ABC-type (unclassified) transport system, ATPase component. (246 aa) |
| | asnS | COG0017 Aspartyl/asparaginyl-tRNA synthetases. (508 aa) |
| | SGRA_1972 | Chromosome segregation ATPase-like protein. (1125 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa) |
| | recA | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (372 aa) |
| | arsA | Arsenite-activated ATPase (arsA) subfamily protein; COG0003 Oxyanion-translocating ATPase. (384 aa) |
| | thrB | COG0083 Homoserine kinase. (303 aa) |
| | SGRA_2030 | Secreted protein. (180 aa) |
| | pheS | COG0016 Phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (345 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (702 aa) |
| | mutS | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (884 aa) |
| | SGRA_2124 | Filamentation induced by cAMP protein Fic. (354 aa) |
| | uvrA | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa) |
| | SGRA_2148 | Hypothetical protein. (490 aa) |
| | SGRA_2152 | COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase). (135 aa) |
| | SGRA_2172 | Hypothetical protein. (1718 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (510 aa) |
| | SGRA_2193 | Hypothetical protein; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. (594 aa) |
| | gldA | Gliding motility protein GldA; COG1131 ABC-type multidrug transport system, ATPase component. (363 aa) |
| | glyS1 | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (519 aa) |
| | SGRA_2251 | DNA mismatch repair protein MutS domain-containing protein; COG0249 Mismatch repair ATPase (MutS family). (589 aa) |
| | trpS | COG0180 Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (338 aa) |
| | SGRA_2287 | ABC transporter, ATP-binding protein; COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase; Belongs to the ABC transporter superfamily. (570 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa) |
| | asnB | COG0367 Asparagine synthase (glutamine-hydrolyzing). (635 aa) |
| | atpA | F0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (534 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (301 aa) |
| | SGRA_2351 | WbqC-like family protein. (210 aa) |
| | pal-3 | OmpA/MotB domain-containing protein; COG0457 FOG: TPR repeat. (675 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa) |
| | hisS | COG0124 Histidyl-tRNA synthetase. (465 aa) |
| | uvrA-2 | UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (930 aa) |
| | SGRA_2500 | Sigma54 specific transcriptional regulator, Fis family protein; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (433 aa) |
| | SGRA_2503 | Hypothetical protein. (326 aa) |
| | pyk | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (341 aa) |
| | SGRA_2572 | SMC domain protein; COG4637 Predicted ATPase. (454 aa) |
| | SGRA_2578 | Von Willebrand factor type A; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (550 aa) |
| | mutS2 | MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa) |
| | SGRA_2615 | CBS domain containing membrane protein; COG0517 FOG: CBS domain. (637 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (162 aa) |
| | SGRA_2628 | COG1428 Deoxynucleoside kinases. (219 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa) |
| | SGRA_2636 | Hypothetical protein. (288 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (302 aa) |
| | dnaB | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (510 aa) |
| | SGRA_2730 | Lipopolysaccharide biosynthesis protein. (372 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (493 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. (437 aa) |
| | clpB | ATP-dependent chaperone ClpB; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. (878 aa) |
| | mvaK1 | COG1577 Mevalonate kinase. (296 aa) |
| | copA | Heavy metal translocating p-type atpase; COG2217 Cation transport ATPase. (739 aa) |
| | pheT | phenylalanyl-tRNA synthetase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (831 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (875 aa) |
| | SGRA_2812 | Biotin/lipoyl attachment domain-containing protein; COG0511 Biotin carboxyl carrier protein. (160 aa) |
| | moxR-3 | MoxR-like ATPase, regulator; COG0714 MoxR-like ATPases. (343 aa) |
| | SGRA_2901 | Hypothetical protein; COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA. (678 aa) |
| | mutL | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (622 aa) |
| | deaD | DEAD/DEAH box helicase domain protein; COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. (474 aa) |
| | ychF | GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (367 aa) |
| | SGRA_2984 | AAA ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (399 aa) |
| | ftsK | COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins. (850 aa) |
| | SGRA_3037 | SMC domain protein; COG1122 ABC-type cobalt transport system, ATPase component. (620 aa) |
| | SGRA_3038 | Hypothetical protein; COG1403 Restriction endonuclease. (319 aa) |
| | SGRA_3059 | Iron ABC transporter ATP-binding protein; COG4559 ABC-type hemin transport system, ATPase component. (267 aa) |
| | SGRA_3086 | COG0464 ATPases of the AAA+ class. (868 aa) |
| | SGRA_3089 | ABC transporter related protein; COG1136 ABC-type antimicrobial peptide transport system, ATPase component. (236 aa) |
| | parA | COG1192 ATPases involved in chromosome partitioning. (258 aa) |
| | SGRA_3100 | MoxR-like protein ATPase-like protein; COG0714 MoxR-like ATPases. (372 aa) |
| | SGRA_3137 | ATPase; COG0714 MoxR-like ATPases. (366 aa) |
| | SGRA_3152 | COG3210 Large exoproteins involved in heme utilization or adhesion. (103 aa) |
| | SGRA_3156 | Hypothetical protein. (473 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (724 aa) |
| | SGRA_3185 | ABC transporter related protein; COG1132 ABC-type multidrug transport system, ATPase and permease components. (600 aa) |
| | SGRA_3212 | Switch protein/serine-threonine kinase; COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase). (132 aa) |
| | SGRA_3213 | Putative anti-sigma regulatory factor, serine/threonine protein kinase; COG0656 Aldo/keto reductases, related to diketogulonate reductase. (200 aa) |
| | recB | UvrD/REP helicase; COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains). (1091 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (658 aa) |
| | SGRA_3257 | Hypothetical protein; COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components. (371 aa) |
| | SGRA_3264 | Hypothetical protein. (205 aa) |
| | SGRA_3293 | ATPase; COG0017 Aspartyl/asparaginyl-tRNA synthetases. (1654 aa) |
| | SGRA_3304 | Hypothetical protein; COG1077 Actin-like ATPase involved in cell morphogenesis. (1163 aa) |
| | clpX | Sigma 54 interacting domain protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (419 aa) |
| | SGRA_3331 | COG2177 Cell division protein. (295 aa) |
| | SGRA_3346 | HlyB/MsbA family ABC transporter; COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain. (580 aa) |
| | anmK | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (545 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (695 aa) |
| | SGRA_3397 | ABC transporter related protein; COG1132 ABC-type multidrug transport system, ATPase and permease components. (597 aa) |
| | lysC | COG0527 Aspartokinases; Belongs to the aspartokinase family. (424 aa) |
| | SGRA_3404 | ATPase-like protein; COG4637 Predicted ATPase. (354 aa) |
| | hsdR-2 | COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (1132 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa) |
| | acs | Acetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa) |
| | mreB | Rod shape-determining protein MreB; COG1077 Actin-like ATPase involved in cell morphogenesis. (344 aa) |
| | SGRA_3539 | Putative ATP binding protein; COG1129 ABC-type sugar transport system, ATPase component. (500 aa) |
| | sms | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (464 aa) |
| | SGRA_3570 | ABC-type transporter ATP-binding protein; COG0488 ATPase components of ABC transporters with duplicated ATPase domains. (622 aa) |
| | SGRA_3606 | Hypothetical protein. (429 aa) |
| | gshB | COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (322 aa) |
| | SGRA_3613 | Hypothetical protein. (481 aa) |
| | recQ-3 | ATP-dependent DNA helicase, RecQ family protein; COG0514 Superfamily II DNA helicase. (654 aa) |
| | comM | Mg chelatase, subunit chli; COG0606 Predicted ATPase with chaperone activity. (518 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa) |
| | SGRA_3683 | Hypothetical protein; COG0457 FOG: TPR repeat. (317 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (405 aa) |
| | SGRA_3694 | Putative lipoprotein. (291 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | SGRA_3722 | ABC transporter related protein; COG1132 ABC-type multidrug transport system, ATPase and permease components. (597 aa) |
| | SGRA_3733 | COG1428 Deoxynucleoside kinases. (210 aa) |
| | macB | ABC transporter related protein; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (250 aa) |
| | SGRA_3772 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (497 aa) |
| | tdk | COG1435 Thymidine kinase. (184 aa) |
| | SGRA_3791 | Hypothetical protein. (493 aa) |
| | cmk | COG0283 Cytidylate kinase. (237 aa) |
| | SGRA_3836 | Serine/threonine protein kinase. (340 aa) |
| | SGRA_3849 | COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. (460 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (191 aa) |
| | SGRA_3869 | SMC domain-containing protein; COG3950 Predicted ATP-binding protein involved in virulence. (433 aa) |
| | SGRA_3877 | COG0513 Superfamily II DNA and RNA helicases; Belongs to the DEAD box helicase family. (414 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | SGRA_3892 | Filamentation induced by cAMP protein Fic. (462 aa) |
| | SGRA_3894 | SMC domain-containing protein; COG3950 Predicted ATP-binding protein involved in virulence. (441 aa) |
| | hsdR-3 | Type I restriction-modification system, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1070 aa) |
| | leuS | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (939 aa) |
| | SGRA_3908 | COG0542 ATPases with chaperone activity, ATP-binding subunit. (1098 aa) |
| | SGRA_3937 | COG0542 ATPases with chaperone activity, ATP-binding subunit. (1098 aa) |
| | pgk | COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa) |
| | SGRA_4016 | Hypothetical protein. (686 aa) |
| | smc | Chromosome segregation protein smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1173 aa) |
| | mnmA | tRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (391 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (423 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (672 aa) |
| | SGRA_4057 | COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component. (428 aa) |
| | asnB-2 | COG0367 Asparagine synthase (glutamine-hydrolyzing). (622 aa) |
| | SGRA_4080 | Heat shock protein Hsp70; COG0443 Molecular chaperone; Belongs to the heat shock protein 70 family. (752 aa) |
| | SGRA_4128 | COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (1036 aa) |
| | SGRA_4129 | Hypothetical protein. (137 aa) |
| | SGRA_4131 | ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (751 aa) |
| | ycaJ | Recombination factor protein RarA; COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase. (424 aa) |
| | argS | COG0018 Arginyl-tRNA synthetase. (644 aa) |
| | uvrD-2 | COG0210 Superfamily I DNA and RNA helicases. (759 aa) |
