STRINGSTRING
SGRA_4169 SGRA_4169 SGRA_4150 SGRA_4150 SGRA_4146 SGRA_4146 lpxD-2 lpxD-2 manB-2 manB-2 SGRA_4058 SGRA_4058 SGRA_4026 SGRA_4026 kdtA kdtA wbpO wbpO gapA-2 gapA-2 pgk pgk SGRA_3883 SGRA_3883 SGRA_3842 SGRA_3842 SGRA_3839 SGRA_3839 SGRA_3792 SGRA_3792 kdsB kdsB gpsA gpsA SGRA_3593 SGRA_3593 SGRA_3482 SGRA_3482 rpe rpe rffA rffA manA manA anmK anmK gpm gpm manB manB SGRA_3177 SGRA_3177 SGRA_3146 SGRA_3146 rfbA-2 rfbA-2 tpiA tpiA SGRA_2903 SGRA_2903 icd-2 icd-2 SGRA_2730 SGRA_2730 wcaJ wcaJ pyk pyk rfbA rfbA kdsA kdsA glgA glgA SGRA_2283 SGRA_2283 SGRA_2276 SGRA_2276 SGRA_2267 SGRA_2267 galE-2 galE-2 SGRA_2135 SGRA_2135 SGRA_2127 SGRA_2127 SGRA_2095 SGRA_2095 SGRA_2074 SGRA_2074 tktA-2 tktA-2 tktA tktA mtnB mtnB pfk pfk SGRA_1965 SGRA_1965 SGRA_1941 SGRA_1941 SGRA_1930 SGRA_1930 lpxD lpxD SGRA_1851 SGRA_1851 SGRA_1814 SGRA_1814 SGRA_1802 SGRA_1802 SGRA_1779 SGRA_1779 ugd ugd rfbB-2 rfbB-2 SGRA_1723 SGRA_1723 sdaA-2 sdaA-2 cysQ cysQ suhB suhB lpxC lpxC lpxA lpxA SGRA_1608 SGRA_1608 SGRA_1562 SGRA_1562 SGRA_1550 SGRA_1550 SGRA_1545 SGRA_1545 SGRA_1536 SGRA_1536 SGRA_1477 SGRA_1477 SGRA_1427 SGRA_1427 SGRA_1359 SGRA_1359 SGRA_1325 SGRA_1325 SGRA_1324 SGRA_1324 SGRA_1264 SGRA_1264 talA talA SGRA_1206 SGRA_1206 SGRA_1151 SGRA_1151 gapA gapA SGRA_1100 SGRA_1100 fbp fbp murG murG lpxH lpxH SGRA_0750 SGRA_0750 lpxB lpxB SGRA_0638 SGRA_0638 eno eno SGRA_0583 SGRA_0583 SGRA_0563 SGRA_0563 pckA pckA lpxK lpxK SGRA_0491 SGRA_0491 SGRA_0396 SGRA_0396 rpiB rpiB pgsA pgsA SGRA_0323 SGRA_0323 SGRA_0319 SGRA_0319 kdsC kdsC SGRA_0153 SGRA_0153 SGRA_0090 SGRA_0090 fbaB fbaB glpK glpK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SGRA_4169NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (350 aa)
SGRA_4150Phosphoesterase PA-phosphatase related protein; COG0671 Membrane-associated phospholipid phosphatase. (190 aa)
SGRA_4146Degt/dnrj/eryc1/strs aminotransferase; COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Belongs to the DegT/DnrJ/EryC1 family. (358 aa)
lpxD-2UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (351 aa)
manB-2COG1109 Phosphomannomutase. (467 aa)
SGRA_40584-alpha-L-fucosyltransferase. (389 aa)
SGRA_4026Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (262 aa)
kdtA3-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (414 aa)
wbpONucleotide sugar dehydrogenase; COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (430 aa)
gapA-2Glyceraldehyde-3-phosphate dehydrogenase, type I; COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa)
SGRA_3883NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (341 aa)
SGRA_3842Nucleotidyl transferase; COG1209 dTDP-glucose pyrophosphorylase. (328 aa)
SGRA_3839Polysaccharide biosynthesis protein; COG2244 Membrane protein involved in the export of O-antigen and teichoic acid. (503 aa)
SGRA_3792COG1358 Ribosomal protein HS6-type (S12/L30/L7a). (435 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (238 aa)
gpsACOG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (348 aa)
SGRA_3593Alginate O-acetylation protein; COG1696 Predicted membrane protein involved in D-alanine export; Belongs to the membrane-bound acyltransferase family. (498 aa)
SGRA_3482RfaQ-like lipopolysaccharide core biosynthesis glycosyl transferase; COG0859 ADP-heptose:LPS heptosyltransferase. (346 aa)
rpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
rffATDP-4-oxo-6-deoxy-D-glucose transaminase; COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Belongs to the DegT/DnrJ/EryC1 family. (379 aa)
manABifunctional phosphoglucose/phosphomannose isomerase; COG0166 Glucose-6-phosphate isomerase. (330 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
manBCOG1109 Phosphomannomutase. (463 aa)
SGRA_3177SoxW; COG1331 Highly conserved protein containing a thioredoxin domain. (215 aa)
SGRA_3146B-glycosyltransferase; COG1216 Predicted glycosyltransferases. (670 aa)
rfbA-2Nucleotidyl transferase; COG1209 dTDP-glucose pyrophosphorylase. (331 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
SGRA_2903Glycosyl transferase family protein. (556 aa)
icd-2COG0538 Isocitrate dehydrogenases. (399 aa)
SGRA_2730Lipopolysaccharide biosynthesis protein. (372 aa)
wcaJCOG2148 Sugar transferases involved in lipopolysaccharide synthesis. (472 aa)
pykCOG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
rfbAGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (289 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. (267 aa)
glgACOG0297 Glycogen synthase. (271 aa)
SGRA_2283Transferase hexapeptide repeat protein; COG0110 Acetyltransferase (isoleucine patch superfamily). (214 aa)
SGRA_2276KpsF/GutQ family protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. (314 aa)
SGRA_2267COG2035 Predicted membrane protein. (302 aa)
galE-2COG1087 UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (347 aa)
SGRA_2135COG1331 Highly conserved protein containing a thioredoxin domain. (368 aa)
SGRA_2127Heptosyltransferase family protein; COG0859 ADP-heptose:LPS heptosyltransferase. (332 aa)
SGRA_2095Hypothetical protein. (550 aa)
SGRA_2074NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (275 aa)
tktA-2COG3958 Transketolase, C-terminal subunit. (317 aa)
tktACOG3959 Transketolase, N-terminal subunit. (281 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (224 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
SGRA_1965Beta-lactamase domain protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Belongs to the UPF0173 family. (232 aa)
SGRA_1941Phosphodiesterase, MJ0936 family protein; COG0622 Predicted phosphoesterase. (173 aa)
SGRA_1930DegT/DnrJ/EryC1/StrS aminotransferase; COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Belongs to the DegT/DnrJ/EryC1 family. (377 aa)
lpxDCOG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase. (325 aa)
SGRA_1851Glycoside hydrolase family 3 domain protein; COG1472 Beta-glucosidase-related glycosidases. (998 aa)
SGRA_1814Collagenase, putative. (269 aa)
SGRA_1802Metallophosphoesterase; COG1408 Predicted phosphohydrolases. (416 aa)
SGRA_1779Hypothetical protein. (680 aa)
ugdNucleotide sugar dehydrogenase; COG1004 Predicted UDP-glucose 6-dehydrogenase. (440 aa)
rfbB-2dTDP-glucose 4,6-dehydratase, NAD-dependent epimerase/dehydratase-related protein; COG0451 Nucleoside-diphosphate-sugar epimerases. (310 aa)
SGRA_1723COG0726 Predicted xylanase/chitin deacetylase. (207 aa)
sdaA-2COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (482 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (263 aa)
suhBInositol monophosphatase; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (268 aa)
lpxC3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (261 aa)
SGRA_1608Peptidase c14 caspase catalytic subunit p20; COG0457 FOG: TPR repeat. (742 aa)
SGRA_1562Thioredoxin domaiN-containing protein; COG0526 Thiol-disulfide isomerase and thioredoxins. (240 aa)
SGRA_1550Polysaccharide biosynthesis protein; COG2244 Membrane protein involved in the export of O-antigen and teichoic acid. (487 aa)
SGRA_1545Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (281 aa)
SGRA_1536COG1331 Highly conserved protein containing a thioredoxin domain. (689 aa)
SGRA_1477Dolichyl-phosphate-mannose-protein mannosyltransferase family protein; COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family. (544 aa)
SGRA_1427Polysaccharide biosynthesis protein; COG2244 Membrane protein involved in the export of O-antigen and teichoic acid. (444 aa)
SGRA_1359Maf-like protein. (269 aa)
SGRA_1325Chitinase II; COG3858 Predicted glycosyl hydrolase. (628 aa)
SGRA_1324Chitinase II; COG3858 Predicted glycosyl hydrolase. (639 aa)
SGRA_1264Hypothetical protein. (491 aa)
talAPutative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
SGRA_1206Polysaccharide deacetylase family protein; COG0726 Predicted xylanase/chitin deacetylase. (341 aa)
SGRA_1151Nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (399 aa)
gapACOG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (495 aa)
SGRA_1100COG5492 Bacterial surface proteins containing Ig-like domains. (494 aa)
fbpCOG0158 Fructose-1,6-bisphosphatase. (327 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (361 aa)
lpxHMetallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (265 aa)
SGRA_0750Cell wall/surface repeat-containing protein; COG5492 Bacterial surface proteins containing Ig-like domains. (2893 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (373 aa)
SGRA_0638NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (324 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
SGRA_0583Xylose isomerase domain-containing protein; COG1082 Sugar phosphate isomerases/epimerases. (277 aa)
SGRA_0563COG1216 Predicted glycosyltransferases. (379 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (361 aa)
SGRA_0491Hypothetical protein. (246 aa)
SGRA_0396Membrane bound o-acyl transferase mboat family protein; COG1696 Predicted membrane protein involved in D-alanine export; Belongs to the membrane-bound acyltransferase family. (487 aa)
rpiBCOG0698 Ribose 5-phosphate isomerase RpiB. (149 aa)
pgsACapsule synthesis protein, CapA; COG2843 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation). (423 aa)
SGRA_0323Hypothetical protein. (479 aa)
SGRA_0319Membrane bound O-acyl transferase MBOAT family protein; COG1696 Predicted membrane protein involved in D-alanine export; Belongs to the membrane-bound acyltransferase family. (477 aa)
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; COG1778 Low specificity phosphatase (HAD superfamily). (174 aa)
SGRA_0153Polysaccharide biosynthesis family protein; COG2244 Membrane protein involved in the export of O-antigen and teichoic acid. (476 aa)
SGRA_0090COG0110 Acetyltransferase (isoleucine patch superfamily). (189 aa)
fbaBCOG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (494 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
Server load: low (14%) [HD]