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SGRA_2615 SGRA_2615 folK folK folP folP folA folA folB folB folE folE SGRA_3526 SGRA_3526 SGRA_3845 SGRA_3845 ggt-2 ggt-2 SGRA_0031 SGRA_0031 panB panB panD panD SGRA_1446 SGRA_1446 folD folD metF metF ggt ggt panC panC SGRA_2545 SGRA_2545 SGRA_0122 SGRA_0122 glyA glyA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene fusions
gene co-occurrence
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SGRA_2615CBS domain containing membrane protein; COG0517 FOG: CBS domain. (637 aa)
folK2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (162 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (284 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (175 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (174 aa)
folECOG0302 GTP cyclohydrolase I. (231 aa)
SGRA_3526COG0262 Dihydrofolate reductase. (176 aa)
SGRA_3845Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (461 aa)
ggt-2Gamma-glutamyltranspeptidase small chain; COG0405 Gamma-glutamyltransferase. (491 aa)
SGRA_0031COG3643 Glutamate formiminotransferase. (561 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (115 aa)
SGRA_1446Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (468 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
metFCOG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
ggtCOG0405 Gamma-glutamyltransferase. (560 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa)
SGRA_2545Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
SGRA_0122COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (435 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (435 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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