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bioA bioA ribE ribE panB panB SGRA_0564 SGRA_0564 panD panD ribBA ribBA SGRA_1114 SGRA_1114 SGRA_1372 SGRA_1372 SGRA_1449 SGRA_1449 thiC thiC thiE thiE thiD thiD thiE-2 thiE-2 thiG thiG bioD bioD thiH thiH serA-2 serA-2 SGRA_1965 SGRA_1965 SGRA_2011 SGRA_2011 pdxH pdxH pdxA pdxA panC panC SGRA_2318 SGRA_2318 thiL thiL serC serC SGRA_2545 SGRA_2545 folK folK ribH ribH pdxJ pdxJ SGRA_4026 SGRA_4026 SGRA_2997 SGRA_2997 SGRA_3027 SGRA_3027 SGRA_3095 SGRA_3095 folB folB SGRA_3668 SGRA_3668 bioB bioB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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bioACOG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa)
ribECOG0307 Riboflavin synthase alpha chain. (198 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa)
SGRA_0564Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (315 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (115 aa)
ribBAGtp cyclohydrolase ii; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (415 aa)
SGRA_1114Cobalamin synthesis protein CobW; COG0523 Putative GTPases (G3E family). (332 aa)
SGRA_1372Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (185 aa)
SGRA_1449COG2104 Sulfur transfer protein involved in thiamine biosynthesis. (90 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa)
thiEThiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (218 aa)
thiDCOG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (253 aa)
thiE-2Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (213 aa)
thiHCOG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (381 aa)
serA-2D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa)
SGRA_1965Beta-lactamase domain protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Belongs to the UPF0173 family. (232 aa)
SGRA_2011HAD-superfamily hydrolase, subfamily IA, variant 3; COG1011 Predicted hydrolase (HAD superfamily). (215 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (223 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. (517 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa)
SGRA_2318Galanin. (302 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa)
SGRA_2545Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
folK2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (162 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (175 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (239 aa)
SGRA_4026Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (262 aa)
SGRA_2997Galanin. (331 aa)
SGRA_3027Regulatory protein (nitrile hydratase activator like); COG0523 Putative GTPases (G3E family). (401 aa)
SGRA_3095Riboflavin biosynthesis protein ribd; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (348 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (174 aa)
SGRA_3668Galanin; COG0556 Helicase subunit of the DNA excision repair complex. (323 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (330 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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