node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SGRA_1373 | hemE | SGRA_1373 | SGRA_3393 | COG1981 Predicted membrane protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.423 |
SGRA_1373 | hemF | SGRA_1373 | SGRA_4068 | COG1981 Predicted membrane protein. | COG0408 Coproporphyrinogen III oxidase. | 0.948 |
SGRA_1373 | hemH | SGRA_1373 | SGRA_0530 | COG1981 Predicted membrane protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.936 |
SGRA_2036 | cyoE | SGRA_2036 | SGRA_1507 | Cytochrome oxidase assembly; COG1612 Uncharacterized protein required for cytochrome oxidase assembly. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | 0.989 |
cyoE | SGRA_2036 | SGRA_1507 | SGRA_2036 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | Cytochrome oxidase assembly; COG1612 Uncharacterized protein required for cytochrome oxidase assembly. | 0.989 |
cyoE | hemF | SGRA_1507 | SGRA_4068 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | COG0408 Coproporphyrinogen III oxidase. | 0.472 |
cyoE | hemH | SGRA_1507 | SGRA_0530 | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.925 |
hemA | hemB | SGRA_2353 | SGRA_4138 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.864 |
hemA | hemC | SGRA_2353 | SGRA_2354 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.987 |
hemA | hemE | SGRA_2353 | SGRA_3393 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.509 |
hemA | hemL | SGRA_2353 | SGRA_3721 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.988 |
hemB | hemA | SGRA_4138 | SGRA_2353 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.864 |
hemB | hemC | SGRA_4138 | SGRA_2354 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.994 |
hemB | hemE | SGRA_4138 | SGRA_3393 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.750 |
hemB | hemL | SGRA_4138 | SGRA_3721 | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. | 0.993 |
hemC | hemA | SGRA_2354 | SGRA_2353 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.987 |
hemC | hemB | SGRA_2354 | SGRA_4138 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.994 |
hemC | hemE | SGRA_2354 | SGRA_3393 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.965 |
hemC | hemF | SGRA_2354 | SGRA_4068 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | COG0408 Coproporphyrinogen III oxidase. | 0.423 |
hemC | hemH | SGRA_2354 | SGRA_0530 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.491 |