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SGRA_1449 SGRA_1449 SGRA_4190 SGRA_4190 ggt-2 ggt-2 bioA bioA SGRA_3845 SGRA_3845 bioB bioB SGRA_3668 SGRA_3668 SGRA_3562 SGRA_3562 acs acs accA accA SGRA_3271 SGRA_3271 iscS-2 iscS-2 SGRA_3170 SGRA_3170 aceF aceF mtnD mtnD metC metC SGRA_2997 SGRA_2997 lipA lipA sucB sucB metH metH SGRA_2615 SGRA_2615 folD folD pdhB pdhB mtnC mtnC mtnA mtnA thiL thiL SGRA_2318 SGRA_2318 SGRA_2247 SGRA_2247 SGRA_2198 SGRA_2198 SGRA_2022 SGRA_2022 SGRA_1884 SGRA_1884 iscU iscU iscS iscS SGRA_1859 SGRA_1859 thiH thiH bioD bioD ggt ggt metF metF hscB hscB thiG thiG thiE-2 thiE-2 thiD thiD thiE thiE thiC thiC SGRA_1446 SGRA_1446 SGRA_1434 SGRA_1434 pdhA pdhA SGRA_1236 SGRA_1236 mtnN mtnN mvaD mvaD metK metK SGRA_1113 SGRA_1113 SGRA_0713 SGRA_0713 prpE prpE accD accD SGRA_0599 SGRA_0599 SGRA_0387 SGRA_0387 SGRA_0369 SGRA_0369 mrp mrp SGRA_0015 SGRA_0015
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SGRA_1449COG2104 Sulfur transfer protein involved in thiamine biosynthesis. (90 aa)
SGRA_4190COG1607 Acyl-CoA hydrolase. (163 aa)
ggt-2Gamma-glutamyltranspeptidase small chain; COG0405 Gamma-glutamyltransferase. (491 aa)
bioACOG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa)
SGRA_3845Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (461 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (330 aa)
SGRA_3668Galanin; COG0556 Helicase subunit of the DNA excision repair complex. (323 aa)
SGRA_3562Hypothetical protein. (790 aa)
acsAcetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
SGRA_3271Hypothetical protein. (92 aa)
iscS-2COG1104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (376 aa)
SGRA_3170Glyoxalase/bleomycin resistance protein/dioxygenase; COG3324 Predicted enzyme related to lactoylglutathione lyase. (120 aa)
aceFPyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (417 aa)
mtnDMethionine salvage pathway protein E-2/E-2'; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (175 aa)
metCCOG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (379 aa)
SGRA_2997Galanin. (331 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (296 aa)
sucB2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1225 aa)
SGRA_2615CBS domain containing membrane protein; COG0517 FOG: CBS domain. (637 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
pdhBTransketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
mtnC2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (226 aa)
mtnAPutative translation initiation factor eIF-2B alpha subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (366 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa)
SGRA_2318Galanin. (302 aa)
SGRA_2247COG2120 Uncharacterized proteins, LmbE homologs. (237 aa)
SGRA_2198COG0694 Thioredoxin-like proteins and domains. (207 aa)
SGRA_2022COG0031 Cysteine synthase. (313 aa)
SGRA_1884Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (108 aa)
iscUFeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (406 aa)
SGRA_1859Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (128 aa)
thiHCOG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (381 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (213 aa)
ggtCOG0405 Gamma-glutamyltransferase. (560 aa)
metFCOG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
hscBCo-chaperone Hsc20; COG1076 DnaJ-domain-containing proteins 1. (176 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
thiE-2Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
thiDCOG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (253 aa)
thiEThiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (218 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa)
SGRA_1446Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (468 aa)
SGRA_1434COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (389 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (335 aa)
SGRA_1236COG2120 Uncharacterized proteins, LmbE homologs. (238 aa)
mtnNPurine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (227 aa)
mvaDCOG3407 Mevalonate pyrophosphate decarboxylase. (347 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (417 aa)
SGRA_1113FeS assembly protein IscX; COG2975 Uncharacterized protein conserved in bacteria. (79 aa)
SGRA_0713Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (172 aa)
prpEprpE protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (627 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
SGRA_0599COG0694 Thioredoxin-like proteins and domains. (82 aa)
SGRA_0387Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (119 aa)
SGRA_0369Lvivd repeat-containing protein. (430 aa)
mrpATP-binding protein, Mrp/Nbp35 family; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (364 aa)
SGRA_0015Calcium-binding EF-hand-containing protein; COG5126 Ca2+-binding protein (EF-Hand superfamily). (150 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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