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| | SGRA_2020 | Thiamine S protein; COG1977 Molybdopterin converting factor, small subunit. (93 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa) |
| | SGRA_2011 | HAD-superfamily hydrolase, subfamily IA, variant 3; COG1011 Predicted hydrolase (HAD superfamily). (215 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | atpC | H+-transporting two-sector ATPase, epsilon subunit; COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit). (79 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa) |
| | lpxD | COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase. (325 aa) |
| | SGRA_1859 | Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (128 aa) |
| | SGRA_1856 | Histidine kinase; COG0642 Signal transduction histidine kinase. (771 aa) |
| | SGRA_1853 | COG3550 Uncharacterized protein related to capsule biosynthesis enzymes. (109 aa) |
| | SGRA_1804 | COG0818 Diacylglycerol kinase. (125 aa) |
| | SGRA_1802 | Metallophosphoesterase; COG1408 Predicted phosphohydrolases. (416 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (335 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa) |
| | ugd | Nucleotide sugar dehydrogenase; COG1004 Predicted UDP-glucose 6-dehydrogenase. (440 aa) |
| | rfbB-2 | dTDP-glucose 4,6-dehydratase, NAD-dependent epimerase/dehydratase-related protein; COG0451 Nucleoside-diphosphate-sugar epimerases. (310 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (263 aa) |
| | suhB | Inositol monophosphatase; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (268 aa) |
| | SGRA_1642 | COG2849 Uncharacterized protein conserved in bacteria. (201 aa) |
| | lpxC | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa) |
| | lpxA | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (261 aa) |
| | nadC | COG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (285 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa) |
| | SGRA_1592 | COG0515 Serine/threonine protein kinase. (349 aa) |
| | SGRA_1579 | Formyl transferase domain protein; COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. (226 aa) |
| | SGRA_1576 | WbqC-like family protein. (229 aa) |
| | SGRA_1545 | Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (281 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa) |
| | phoR-2 | Histidine kinase; COG0642 Signal transduction histidine kinase. (500 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | thiE-2 | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa) |
| | thiD | COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (253 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (218 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa) |
| | SGRA_1449 | COG2104 Sulfur transfer protein involved in thiamine biosynthesis. (90 aa) |
| | SGRA_1358 | Hypothetical protein. (310 aa) |
| | SGRA_1340 | PfkB domain protein; COG0524 Sugar kinases, ribokinase family. (304 aa) |
| | pdhA | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (335 aa) |
| | SGRA_1298 | COG2849 Uncharacterized protein conserved in bacteria. (237 aa) |
| | SGRA_1279 | Hypothetical protein. (104 aa) |
| | pleC1 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. (678 aa) |
| | talA | Putative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa) |
| | SGRA_1248 | O-methyltransferase family 2. (231 aa) |
| | mvaD | COG3407 Mevalonate pyrophosphate decarboxylase. (347 aa) |
| | relA | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (765 aa) |
| | SGRA_1151 | Nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (399 aa) |
| | udk | COG0572 Uridine kinase. (209 aa) |
| | SGRA_1082 | Serine/threonine protein kinase; COG2815 Uncharacterized protein conserved in bacteria. (302 aa) |
| | elaA | GCN5-like N-acetyltransferase; COG2153 Predicted acyltransferase. (153 aa) |
| | SGRA_1936 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (665 aa) |
| | cinA | Competence/damage-inducible protein CinA; COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Belongs to the CinA family. (419 aa) |
| | fbaB | COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (494 aa) |
| | SGRA_0075 | COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (395 aa) |
| | SGRA_0085 | Lipoprotein. (602 aa) |
| | SGRA_0090 | COG0110 Acetyltransferase (isoleucine patch superfamily). (189 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | SGRA_0111 | Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (412 aa) |
| | SGRA_0138 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (850 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | SGRA_0178 | Signal transduction histidine kinase, LytS; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (352 aa) |
| | phoR | Histidine kinase; COG0642 Signal transduction histidine kinase. (355 aa) |
| | SGRA_0285 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (811 aa) |
| | SGRA_0300 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (691 aa) |
| | SGRA_0326 | Histidine kinase; COG0642 Signal transduction histidine kinase. (1237 aa) |
| | plsB | COG2937 Glycerol-3-phosphate O-acyltransferase. (579 aa) |
| | dacA | Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (256 aa) |
| | SGRA_0468 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (888 aa) |
| | nnrE | Putative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] (517 aa) |
| | SGRA_0491 | Hypothetical protein. (246 aa) |
| | SGRA_0494 | Signal transduction histidine kinase, LytS; COG3275 Putative regulator of cell autolysis. (354 aa) |
| | SGRA_0497 | COG0631 Serine/threonine protein phosphatase. (293 aa) |
| | SGRA_0498 | COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (733 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (361 aa) |
| | SGRA_0564 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (315 aa) |
| | SGRA_0590 | Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (400 aa) |
| | degS | Multi-sensor signal transduction histidine kinase; COG2202 FOG: PAS/PAC domain. (1047 aa) |
| | SGRA_0615 | Putative acyltransferase; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (269 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | SGRA_0638 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (324 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | SGRA_0649 | COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases. (478 aa) |
| | prpE | prpE protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (627 aa) |
| | SGRA_0662 | COG2849 Uncharacterized protein conserved in bacteria. (176 aa) |
| | SGRA_0688 | COG2849 Uncharacterized protein conserved in bacteria. (218 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (422 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (373 aa) |
| | add | COG1816 Adenosine deaminase. (431 aa) |
| | SGRA_0713 | Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (172 aa) |
| | SGRA_0742 | Glutamate-rich protein grpB. (177 aa) |
| | SGRA_0798 | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (286 aa) |
| | lpxH | Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (265 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (247 aa) |
| | ppnK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase small chain; COG0208 Ribonucleotide reductase, beta subunit. (323 aa) |
| | SGRA_1013 | Acyltransferase family protein; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (200 aa) |
| | SGRA_4226 | Metallophosphoesterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. (319 aa) |
| | SGRA_4225 | 5'-Nucleotidase domain protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases. (252 aa) |
| | SGRA_4190 | COG1607 Acyl-CoA hydrolase. (163 aa) |
| | SGRA_4188 | Hypothetical protein; COG2971 Predicted N-acetylglucosamine kinase. (281 aa) |
| | SGRA_4169 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (350 aa) |
| | SGRA_4150 | Phosphoesterase PA-phosphatase related protein; COG0671 Membrane-associated phospholipid phosphatase. (190 aa) |
| | glpA | COG0578 Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (554 aa) |
| | lpxD-2 | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (351 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | hpt | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa) |
| | SGRA_4004 | Ribonuclease HII. (897 aa) |
| | pgk | COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | SGRA_3883 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (341 aa) |
| | plsC | COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (247 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (191 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa) |
| | SGRA_3836 | Serine/threonine protein kinase. (340 aa) |
| | cmk | COG0283 Cytidylate kinase. (237 aa) |
| | SGRA_3791 | Hypothetical protein. (493 aa) |
| | tdk | COG1435 Thymidine kinase. (184 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (238 aa) |
| | mazG | Nucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. (254 aa) |
| | SGRA_3733 | COG1428 Deoxynucleoside kinases. (210 aa) |
| | SGRA_3716 | Hypothetical protein; COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (181 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | sucB-2 | Catalytic domain of components of various dehydrogenase complexes; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (441 aa) |
| | SGRA_3668 | Galanin; COG0556 Helicase subunit of the DNA excision repair complex. (323 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa) |
| | SGRA_3648 | Hypothetical protein; COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase. (271 aa) |
| | fcl | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (301 aa) |
| | gpsA | COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (348 aa) |
| | SGRA_3573 | Haloacid dehalogenase, type ii; COG1011 Predicted hydrolase (HAD superfamily). (263 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (439 aa) |
| | SGRA_3549 | Histidine kinase; COG0642 Signal transduction histidine kinase. (326 aa) |
| | rpe | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa) |
| | acs | Acetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa) |
| | SGRA_3446 | Histidine kinase; COG0591 Na+/proline symporter. (895 aa) |
| | SGRA_3436 | hydroxymethylglutaryl-CoA reductase, degradative; COG1257 Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (460 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa) |
| | lysC | COG0527 Aspartokinases; Belongs to the aspartokinase family. (424 aa) |
| | SGRA_3396 | 5 nucleotidase deoxy cytosolic type C; COG4502 Uncharacterized protein conserved in bacteria. (149 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (695 aa) |
| | manA | Bifunctional phosphoglucose/phosphomannose isomerase; COG0166 Glucose-6-phosphate isomerase. (330 aa) |
| | SGRA_3379 | COG0286 Type I restriction-modification system methyltransferase subunit. (911 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (545 aa) |
| | anmK | anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa) |
| | folE | COG0302 GTP cyclohydrolase I. (231 aa) |
| | bacA | Putative bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (320 aa) |
| | gpm | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (484 aa) |
| | SGRA_3250 | Histidine kinase; COG0642 Signal transduction histidine kinase. (394 aa) |
| | SGRA_3231 | COG2849 Uncharacterized protein conserved in bacteria. (484 aa) |
| | cheA | COG0643 Chemotaxis protein histidine kinase and related kinases. (551 aa) |
| | SGRA_3213 | Putative anti-sigma regulatory factor, serine/threonine protein kinase; COG0656 Aldo/keto reductases, related to diketogulonate reductase. (200 aa) |
| | SGRA_3212 | Switch protein/serine-threonine kinase; COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase). (132 aa) |
| | surE | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (293 aa) |
| | SGRA_3170 | Glyoxalase/bleomycin resistance protein/dioxygenase; COG3324 Predicted enzyme related to lactoylglutathione lyase. (120 aa) |
| | SGRA_3156 | Hypothetical protein. (473 aa) |
| | SGRA_3081 | Putative thioredoxin; COG2849 Uncharacterized protein conserved in bacteria. (644 aa) |
| | aceF | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (417 aa) |
| | SGRA_3022 | Morn variant repeat-containing protein; COG2849 Uncharacterized protein conserved in bacteria. (324 aa) |
| | SGRA_2997 | Galanin. (331 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa) |
| | SGRA_2947 | Extracellular nuclease. (679 aa) |
| | dcd | COG0717 Deoxycytidine deaminase. (178 aa) |
| | SGRA_2864 | Morn variant repeat-containing protein; COG2849 Uncharacterized protein conserved in bacteria. (238 aa) |
| | mvaK1 | COG1577 Mevalonate kinase. (296 aa) |
| | pcrB | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). (236 aa) |
| | sucB | 2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa) |
| | argK | Arginine/ornithine transport system ATPase; COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family. (360 aa) |
| | SGRA_2636 | Hypothetical protein. (288 aa) |
| | SGRA_2628 | COG1428 Deoxynucleoside kinases. (219 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (162 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa) |
| | SGRA_2567 | TPR repeat-containing protein; COG0457 FOG: TPR repeat. (297 aa) |
| | SGRA_2545 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa) |
| | pdhB | Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa) |
| | upp | COG0035 Uracil phosphoribosyltransferase. (219 aa) |
| | pyk | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa) |
| | SGRA_2503 | Hypothetical protein. (326 aa) |
| | SGRA_2475 | MazG nucleotide pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. (113 aa) |
| | SGRA_2458 | COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (428 aa) |
| | maf | Maf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (205 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa) |
| | SGRA_2351 | WbqC-like family protein. (210 aa) |
| | SGRA_2349 | Phospholipase D/Transphosphatidylase; COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes. (543 aa) |
| | SGRA_2347 | Metal dependent phosphohydrolase; COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (186 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (301 aa) |
| | atpA | F0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (534 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (186 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (173 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (64 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (421 aa) |
| | SGRA_2329 | Putative deoxyribonucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (195 aa) |
| | pssA | CDP-diacylglycerol-serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa) |
| | SGRA_2318 | Galanin. (302 aa) |
| | ppa | COG0221 Inorganic pyrophosphatase. (209 aa) |
| | SGRA_2283 | Transferase hexapeptide repeat protein; COG0110 Acetyltransferase (isoleucine patch superfamily). (214 aa) |
| | SGRA_2279 | COG0394 Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (150 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (223 aa) |
| | SGRA_2267 | COG2035 Predicted membrane protein. (302 aa) |
| | SGRA_2249 | COG1257 Hydroxymethylglutaryl-CoA reductase. (515 aa) |
| | SGRA_2193 | Hypothetical protein; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. (594 aa) |
| | SGRA_2152 | COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase). (135 aa) |
| | SGRA_2092 | Histidine kinase; COG0642 Signal transduction histidine kinase. (728 aa) |
| | SGRA_2074 | NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (275 aa) |
| | SGRA_2073 | COG2849 Uncharacterized protein conserved in bacteria. (282 aa) |
| | SGRA_2068 | Metal dependent phosphohydrolase; COG1078 HD superfamily phosphohydrolases. (406 aa) |
| | thrB | COG0083 Homoserine kinase. (303 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. (286 aa) |
