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SGRA_2020 SGRA_2020 coaE coaE SGRA_2011 SGRA_2011 atpD atpD atpC atpC pfk pfk lpxD lpxD SGRA_1859 SGRA_1859 SGRA_1856 SGRA_1856 SGRA_1853 SGRA_1853 SGRA_1804 SGRA_1804 SGRA_1802 SGRA_1802 nadA nadA deoC deoC ugd ugd rfbB-2 rfbB-2 cysQ cysQ suhB suhB SGRA_1642 SGRA_1642 lpxC lpxC lpxA lpxA nadC nadC pyrH pyrH SGRA_1592 SGRA_1592 SGRA_1579 SGRA_1579 SGRA_1576 SGRA_1576 SGRA_1545 SGRA_1545 prsA prsA phoR-2 phoR-2 thiG thiG thiE-2 thiE-2 thiD thiD thiE thiE thiC thiC SGRA_1449 SGRA_1449 SGRA_1358 SGRA_1358 SGRA_1340 SGRA_1340 pdhA pdhA SGRA_1298 SGRA_1298 SGRA_1279 SGRA_1279 pleC1 pleC1 talA talA SGRA_1248 SGRA_1248 mvaD mvaD relA relA SGRA_1151 SGRA_1151 udk udk SGRA_1082 SGRA_1082 elaA elaA SGRA_1936 SGRA_1936 cinA cinA fbaB fbaB glpK glpK SGRA_0075 SGRA_0075 SGRA_0085 SGRA_0085 SGRA_0090 SGRA_0090 thyA thyA SGRA_0111 SGRA_0111 SGRA_0138 SGRA_0138 pyrG pyrG SGRA_0178 SGRA_0178 phoR phoR SGRA_0285 SGRA_0285 SGRA_0300 SGRA_0300 SGRA_0326 SGRA_0326 plsB plsB dacA dacA SGRA_0468 SGRA_0468 nnrE nnrE SGRA_0491 SGRA_0491 SGRA_0494 SGRA_0494 SGRA_0497 SGRA_0497 SGRA_0498 SGRA_0498 kynU kynU lpxK lpxK SGRA_0564 SGRA_0564 SGRA_0590 SGRA_0590 degS degS SGRA_0615 SGRA_0615 eno eno adk adk SGRA_0638 SGRA_0638 accD accD SGRA_0649 SGRA_0649 prpE prpE SGRA_0662 SGRA_0662 SGRA_0688 SGRA_0688 purA purA lpxB lpxB add add SGRA_0713 SGRA_0713 SGRA_0742 SGRA_0742 SGRA_0798 SGRA_0798 lpxH lpxH coaX coaX ppnK ppnK nrdB nrdB SGRA_1013 SGRA_1013 SGRA_4226 SGRA_4226 SGRA_4225 SGRA_4225 SGRA_4190 SGRA_4190 SGRA_4188 SGRA_4188 SGRA_4169 SGRA_4169 SGRA_4150 SGRA_4150 glpA glpA lpxD-2 lpxD-2 coaD coaD hpt hpt SGRA_4004 SGRA_4004 pgk pgk gmk gmk SGRA_3883 SGRA_3883 plsC plsC nadD nadD dut dut SGRA_3836 SGRA_3836 cmk cmk SGRA_3791 SGRA_3791 tdk tdk kdsB kdsB mazG mazG SGRA_3733 SGRA_3733 SGRA_3716 SGRA_3716 ndk ndk sucB-2 sucB-2 SGRA_3668 SGRA_3668 purK purK purE purE SGRA_3648 SGRA_3648 fcl fcl gpsA gpsA SGRA_3573 SGRA_3573 murA murA SGRA_3549 SGRA_3549 rpe rpe acs acs SGRA_3446 SGRA_3446 SGRA_3436 SGRA_3436 aroK aroK lysC lysC SGRA_3396 SGRA_3396 ppk ppk manA manA SGRA_3379 SGRA_3379 accA accA nadE nadE anmK anmK nadB nadB folE folE bacA bacA gpm gpm pncB pncB SGRA_3250 SGRA_3250 SGRA_3231 SGRA_3231 cheA cheA SGRA_3213 SGRA_3213 SGRA_3212 SGRA_3212 surE surE psd psd SGRA_3170 SGRA_3170 SGRA_3156 SGRA_3156 SGRA_3081 SGRA_3081 aceF aceF SGRA_3022 SGRA_3022 SGRA_2997 SGRA_2997 tpiA tpiA SGRA_2947 SGRA_2947 dcd dcd SGRA_2864 SGRA_2864 mvaK1 mvaK1 pcrB pcrB sucB sucB argK argK SGRA_2636 SGRA_2636 SGRA_2628 SGRA_2628 folK folK folD folD SGRA_2567 SGRA_2567 SGRA_2545 SGRA_2545 pdhB pdhB upp upp pyk pyk SGRA_2503 SGRA_2503 SGRA_2475 SGRA_2475 SGRA_2458 SGRA_2458 maf maf thiL thiL SGRA_2351 SGRA_2351 SGRA_2349 SGRA_2349 SGRA_2347 SGRA_2347 atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB SGRA_2329 SGRA_2329 pssA pssA SGRA_2318 SGRA_2318 ppa ppa SGRA_2283 SGRA_2283 SGRA_2279 SGRA_2279 pdxH pdxH SGRA_2267 SGRA_2267 SGRA_2249 SGRA_2249 SGRA_2193 SGRA_2193 SGRA_2152 SGRA_2152 SGRA_2092 SGRA_2092 SGRA_2074 SGRA_2074 SGRA_2073 SGRA_2073 SGRA_2068 SGRA_2068 thrB thrB cdsA cdsA
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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SGRA_2020Thiamine S protein; COG1977 Molybdopterin converting factor, small subunit. (93 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
SGRA_2011HAD-superfamily hydrolase, subfamily IA, variant 3; COG1011 Predicted hydrolase (HAD superfamily). (215 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (502 aa)
atpCH+-transporting two-sector ATPase, epsilon subunit; COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit). (79 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
lpxDCOG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase. (325 aa)
SGRA_1859Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (128 aa)
SGRA_1856Histidine kinase; COG0642 Signal transduction histidine kinase. (771 aa)
SGRA_1853COG3550 Uncharacterized protein related to capsule biosynthesis enzymes. (109 aa)
SGRA_1804COG0818 Diacylglycerol kinase. (125 aa)
SGRA_1802Metallophosphoesterase; COG1408 Predicted phosphohydrolases. (416 aa)
nadAQuinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (335 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa)
ugdNucleotide sugar dehydrogenase; COG1004 Predicted UDP-glucose 6-dehydrogenase. (440 aa)
rfbB-2dTDP-glucose 4,6-dehydratase, NAD-dependent epimerase/dehydratase-related protein; COG0451 Nucleoside-diphosphate-sugar epimerases. (310 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (263 aa)
suhBInositol monophosphatase; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (268 aa)
SGRA_1642COG2849 Uncharacterized protein conserved in bacteria. (201 aa)
lpxC3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (261 aa)
nadCCOG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (285 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
SGRA_1592COG0515 Serine/threonine protein kinase. (349 aa)
SGRA_1579Formyl transferase domain protein; COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. (226 aa)
SGRA_1576WbqC-like family protein. (229 aa)
SGRA_1545Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (281 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa)
phoR-2Histidine kinase; COG0642 Signal transduction histidine kinase. (500 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
thiE-2Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
thiDCOG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (253 aa)
thiEThiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (218 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa)
SGRA_1449COG2104 Sulfur transfer protein involved in thiamine biosynthesis. (90 aa)
SGRA_1358Hypothetical protein. (310 aa)
SGRA_1340PfkB domain protein; COG0524 Sugar kinases, ribokinase family. (304 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (335 aa)
SGRA_1298COG2849 Uncharacterized protein conserved in bacteria. (237 aa)
SGRA_1279Hypothetical protein. (104 aa)
pleC1Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. (678 aa)
talAPutative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
SGRA_1248O-methyltransferase family 2. (231 aa)
mvaDCOG3407 Mevalonate pyrophosphate decarboxylase. (347 aa)
relA(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (765 aa)
SGRA_1151Nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (399 aa)
udkCOG0572 Uridine kinase. (209 aa)
SGRA_1082Serine/threonine protein kinase; COG2815 Uncharacterized protein conserved in bacteria. (302 aa)
elaAGCN5-like N-acetyltransferase; COG2153 Predicted acyltransferase. (153 aa)
SGRA_19363-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (665 aa)
cinACompetence/damage-inducible protein CinA; COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Belongs to the CinA family. (419 aa)
fbaBCOG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (494 aa)
SGRA_0075COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (395 aa)
SGRA_0085Lipoprotein. (602 aa)
SGRA_0090COG0110 Acetyltransferase (isoleucine patch superfamily). (189 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
SGRA_0111Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (412 aa)
SGRA_0138COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (850 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
SGRA_0178Signal transduction histidine kinase, LytS; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (352 aa)
phoRHistidine kinase; COG0642 Signal transduction histidine kinase. (355 aa)
SGRA_0285COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (811 aa)
SGRA_0300COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (691 aa)
SGRA_0326Histidine kinase; COG0642 Signal transduction histidine kinase. (1237 aa)
plsBCOG2937 Glycerol-3-phosphate O-acyltransferase. (579 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (256 aa)
SGRA_0468COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (888 aa)
nnrEPutative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] (517 aa)
SGRA_0491Hypothetical protein. (246 aa)
SGRA_0494Signal transduction histidine kinase, LytS; COG3275 Putative regulator of cell autolysis. (354 aa)
SGRA_0497COG0631 Serine/threonine protein phosphatase. (293 aa)
SGRA_0498COG4248 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains. (733 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (361 aa)
SGRA_0564Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (315 aa)
SGRA_0590Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (400 aa)
degSMulti-sensor signal transduction histidine kinase; COG2202 FOG: PAS/PAC domain. (1047 aa)
SGRA_0615Putative acyltransferase; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (269 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa)
SGRA_0638NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (324 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
SGRA_0649COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases. (478 aa)
prpEprpE protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (627 aa)
SGRA_0662COG2849 Uncharacterized protein conserved in bacteria. (176 aa)
SGRA_0688COG2849 Uncharacterized protein conserved in bacteria. (218 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (422 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (373 aa)
addCOG1816 Adenosine deaminase. (431 aa)
SGRA_0713Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (172 aa)
SGRA_0742Glutamate-rich protein grpB. (177 aa)
SGRA_0798COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (286 aa)
lpxHMetallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (265 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (247 aa)
ppnKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa)
nrdBRibonucleoside-diphosphate reductase small chain; COG0208 Ribonucleotide reductase, beta subunit. (323 aa)
SGRA_1013Acyltransferase family protein; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (200 aa)
SGRA_4226Metallophosphoesterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. (319 aa)
SGRA_42255'-Nucleotidase domain protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases. (252 aa)
SGRA_4190COG1607 Acyl-CoA hydrolase. (163 aa)
SGRA_4188Hypothetical protein; COG2971 Predicted N-acetylglucosamine kinase. (281 aa)
SGRA_4169NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (350 aa)
SGRA_4150Phosphoesterase PA-phosphatase related protein; COG0671 Membrane-associated phospholipid phosphatase. (190 aa)
glpACOG0578 Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (554 aa)
lpxD-2UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (351 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
hptCOG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa)
SGRA_4004Ribonuclease HII. (897 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
SGRA_3883NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (341 aa)
plsCCOG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (247 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (191 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
SGRA_3836Serine/threonine protein kinase. (340 aa)
cmkCOG0283 Cytidylate kinase. (237 aa)
SGRA_3791Hypothetical protein. (493 aa)
tdkCOG1435 Thymidine kinase. (184 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (238 aa)
mazGNucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. (254 aa)
SGRA_3733COG1428 Deoxynucleoside kinases. (210 aa)
SGRA_3716Hypothetical protein; COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (181 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
sucB-2Catalytic domain of components of various dehydrogenase complexes; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (441 aa)
SGRA_3668Galanin; COG0556 Helicase subunit of the DNA excision repair complex. (323 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa)
SGRA_3648Hypothetical protein; COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase. (271 aa)
fclGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (301 aa)
gpsACOG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (348 aa)
SGRA_3573Haloacid dehalogenase, type ii; COG1011 Predicted hydrolase (HAD superfamily). (263 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (439 aa)
SGRA_3549Histidine kinase; COG0642 Signal transduction histidine kinase. (326 aa)
rpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
acsAcetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa)
SGRA_3446Histidine kinase; COG0591 Na+/proline symporter. (895 aa)
SGRA_3436hydroxymethylglutaryl-CoA reductase, degradative; COG1257 Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (460 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa)
lysCCOG0527 Aspartokinases; Belongs to the aspartokinase family. (424 aa)
SGRA_33965 nucleotidase deoxy cytosolic type C; COG4502 Uncharacterized protein conserved in bacteria. (149 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (695 aa)
manABifunctional phosphoglucose/phosphomannose isomerase; COG0166 Glucose-6-phosphate isomerase. (330 aa)
SGRA_3379COG0286 Type I restriction-modification system methyltransferase subunit. (911 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (545 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa)
folECOG0302 GTP cyclohydrolase I. (231 aa)
bacAPutative bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (320 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
pncBNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (484 aa)
SGRA_3250Histidine kinase; COG0642 Signal transduction histidine kinase. (394 aa)
SGRA_3231COG2849 Uncharacterized protein conserved in bacteria. (484 aa)
cheACOG0643 Chemotaxis protein histidine kinase and related kinases. (551 aa)
SGRA_3213Putative anti-sigma regulatory factor, serine/threonine protein kinase; COG0656 Aldo/keto reductases, related to diketogulonate reductase. (200 aa)
SGRA_3212Switch protein/serine-threonine kinase; COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase). (132 aa)
surE5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (293 aa)
SGRA_3170Glyoxalase/bleomycin resistance protein/dioxygenase; COG3324 Predicted enzyme related to lactoylglutathione lyase. (120 aa)
SGRA_3156Hypothetical protein. (473 aa)
SGRA_3081Putative thioredoxin; COG2849 Uncharacterized protein conserved in bacteria. (644 aa)
aceFPyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (417 aa)
SGRA_3022Morn variant repeat-containing protein; COG2849 Uncharacterized protein conserved in bacteria. (324 aa)
SGRA_2997Galanin. (331 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
SGRA_2947Extracellular nuclease. (679 aa)
dcdCOG0717 Deoxycytidine deaminase. (178 aa)
SGRA_2864Morn variant repeat-containing protein; COG2849 Uncharacterized protein conserved in bacteria. (238 aa)
mvaK1COG1577 Mevalonate kinase. (296 aa)
pcrBGeranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). (236 aa)
sucB2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa)
argKArginine/ornithine transport system ATPase; COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family. (360 aa)
SGRA_2636Hypothetical protein. (288 aa)
SGRA_2628COG1428 Deoxynucleoside kinases. (219 aa)
folK2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (162 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
SGRA_2567TPR repeat-containing protein; COG0457 FOG: TPR repeat. (297 aa)
SGRA_2545Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
pdhBTransketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
uppCOG0035 Uracil phosphoribosyltransferase. (219 aa)
pykCOG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
SGRA_2503Hypothetical protein. (326 aa)
SGRA_2475MazG nucleotide pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. (113 aa)
SGRA_2458COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (428 aa)
mafMaf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (205 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa)
SGRA_2351WbqC-like family protein. (210 aa)
SGRA_2349Phospholipase D/Transphosphatidylase; COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes. (543 aa)
SGRA_2347Metal dependent phosphohydrolase; COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (186 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (301 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (534 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (186 aa)
atpFATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (173 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (64 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (421 aa)
SGRA_2329Putative deoxyribonucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (195 aa)
pssACDP-diacylglycerol-serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa)
SGRA_2318Galanin. (302 aa)
ppaCOG0221 Inorganic pyrophosphatase. (209 aa)
SGRA_2283Transferase hexapeptide repeat protein; COG0110 Acetyltransferase (isoleucine patch superfamily). (214 aa)
SGRA_2279COG0394 Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (150 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (223 aa)
SGRA_2267COG2035 Predicted membrane protein. (302 aa)
SGRA_2249COG1257 Hydroxymethylglutaryl-CoA reductase. (515 aa)
SGRA_2193Hypothetical protein; COG0503 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins. (594 aa)
SGRA_2152COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase). (135 aa)
SGRA_2092Histidine kinase; COG0642 Signal transduction histidine kinase. (728 aa)
SGRA_2074NAD-dependent epimerase/dehydratase; COG0451 Nucleoside-diphosphate-sugar epimerases. (275 aa)
SGRA_2073COG2849 Uncharacterized protein conserved in bacteria. (282 aa)
SGRA_2068Metal dependent phosphohydrolase; COG1078 HD superfamily phosphohydrolases. (406 aa)
thrBCOG0083 Homoserine kinase. (303 aa)
cdsAPhosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. (286 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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