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accD accD SGRA_0615 SGRA_0615 lpxK lpxK SGRA_0491 SGRA_0491 plsB plsB fabD fabD SGRA_0323 SGRA_0323 kdsC kdsC uppS uppS SGRA_0090 SGRA_0090 SGRA_0075 SGRA_0075 SGRA_3482 SGRA_3482 accA accA psd psd htrB htrB lipA lipA fabH-2 fabH-2 SGRA_2914 SGRA_2914 SGRA_2903 SGRA_2903 mvaK1 mvaK1 fabH fabH SGRA_2730 SGRA_2730 pcrB pcrB SGRA_2636 SGRA_2636 accB accB acpP acpP fabF fabF SGRA_2458 SGRA_2458 SGRA_2392 SGRA_2392 SGRA_2349 SGRA_2349 pssA pssA kdsA kdsA SGRA_2283 SGRA_2283 SGRA_2267 SGRA_2267 SGRA_2127 SGRA_2127 fabI-2 fabI-2 SGRA_2095 SGRA_2095 SGRA_2083 SGRA_2083 cdsA cdsA gpsA gpsA lpxD lpxD galE galE SGRA_1804 SGRA_1804 SGRA_1802 SGRA_1802 lpxC lpxC lpxA lpxA SGRA_1545 SGRA_1545 SGRA_1477 SGRA_1477 fabI fabI fabZ fabZ SGRA_1401 SGRA_1401 SGRA_1358 SGRA_1358 SGRA_1264 SGRA_1264 mvaD mvaD SGRA_1151 SGRA_1151 SGRA_1085 SGRA_1085 SGRA_1067 SGRA_1067 crtR crtR SGRA_1013 SGRA_1013 lpxH lpxH lpxB lpxB SGRA_0690 SGRA_0690 SGRA_4150 SGRA_4150 lpxD-2 lpxD-2 kdtA kdtA SGRA_3933 SGRA_3933 SGRA_3932 SGRA_3932 plsC plsC kdsB kdsB ispB ispB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
SGRA_0615Putative acyltransferase; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (269 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (361 aa)
SGRA_0491Hypothetical protein. (246 aa)
plsBCOG2937 Glycerol-3-phosphate O-acyltransferase. (579 aa)
fabDCOG0331 (acyl-carrier-protein) S-malonyltransferase. (293 aa)
SGRA_0323Hypothetical protein. (479 aa)
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; COG1778 Low specificity phosphatase (HAD superfamily). (174 aa)
uppSUndecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa)
SGRA_0090COG0110 Acetyltransferase (isoleucine patch superfamily). (189 aa)
SGRA_0075COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (395 aa)
SGRA_3482RfaQ-like lipopolysaccharide core biosynthesis glycosyl transferase; COG0859 ADP-heptose:LPS heptosyltransferase. (346 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (293 aa)
htrBCOG1560 Lauroyl/myristoyl acyltransferase. (295 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (296 aa)
fabH-2COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III. (358 aa)
SGRA_2914Squalene/phytoene synthase; COG1562 Phytoene/squalene synthetase. (280 aa)
SGRA_2903Glycosyl transferase family protein. (556 aa)
mvaK1COG1577 Mevalonate kinase. (296 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (352 aa)
SGRA_2730Lipopolysaccharide biosynthesis protein. (372 aa)
pcrBGeranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). (236 aa)
SGRA_2636Hypothetical protein. (288 aa)
accBBiotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (171 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa)
fabF3-oxoacyl-(acyl-carrier-protein) synthase ii; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (416 aa)
SGRA_2458COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (428 aa)
SGRA_2392COG3000 Sterol desaturase. (401 aa)
SGRA_2349Phospholipase D/Transphosphatidylase; COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes. (543 aa)
pssACDP-diacylglycerol-serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. (267 aa)
SGRA_2283Transferase hexapeptide repeat protein; COG0110 Acetyltransferase (isoleucine patch superfamily). (214 aa)
SGRA_2267COG2035 Predicted membrane protein. (302 aa)
SGRA_2127Heptosyltransferase family protein; COG0859 ADP-heptose:LPS heptosyltransferase. (332 aa)
fabI-2COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH). (294 aa)
SGRA_2095Hypothetical protein. (550 aa)
SGRA_2083Polyprenyl synthetase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (328 aa)
cdsAPhosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. (286 aa)
gpsACOG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (348 aa)
lpxDCOG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase. (325 aa)
galENAD dependent epimerase; COG0451 Nucleoside-diphosphate-sugar epimerases. (330 aa)
SGRA_1804COG0818 Diacylglycerol kinase. (125 aa)
SGRA_1802Metallophosphoesterase; COG1408 Predicted phosphohydrolases. (416 aa)
lpxC3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (261 aa)
SGRA_1545Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (281 aa)
SGRA_1477Dolichyl-phosphate-mannose-protein mannosyltransferase family protein; COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family. (544 aa)
fabIShort-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (261 aa)
fabZ(3R)-hydroxymyristoyl-[acyl-carrier- protein]dehydratase; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases. (153 aa)
SGRA_1401Beta-ketoacyl synthase; COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (427 aa)
SGRA_1358Hypothetical protein. (310 aa)
SGRA_1264Hypothetical protein. (491 aa)
mvaDCOG3407 Mevalonate pyrophosphate decarboxylase. (347 aa)
SGRA_1151Nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (399 aa)
SGRA_1085Transmembrane prediction. (237 aa)
SGRA_1067COG1233 Phytoene dehydrogenase and related proteins. (494 aa)
crtRBeta-carotene hydroxylase. (154 aa)
SGRA_1013Acyltransferase family protein; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (200 aa)
lpxHMetallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (265 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (373 aa)
SGRA_0690Alcohol dehydrogenase zinc-binding domain protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (336 aa)
SGRA_4150Phosphoesterase PA-phosphatase related protein; COG0671 Membrane-associated phospholipid phosphatase. (190 aa)
lpxD-2UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (351 aa)
kdtA3-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (414 aa)
SGRA_39334'-phosphopantetheinyl transferase superfamily protein; COG0736 Phosphopantetheinyl transferase (holo-ACP synthase); Belongs to the P-Pant transferase superfamily. (190 aa)
SGRA_3932Acyl carrier protein. (81 aa)
plsCCOG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (247 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (238 aa)
ispBPolyprenyl synthetase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (326 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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