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asnB-2 asnB-2 dapB dapB lysC lysC dapA dapA mtnD mtnD SGRA_2872 SGRA_2872 sucB sucB metH metH folD folD mtnC mtnC SGRA_1115 SGRA_1115 mtnN mtnN hipO hipO dapF dapF metF metF thrB thrB dapD dapD lysA lysA asnB asnB SGRA_2422 SGRA_2422 mtnA mtnA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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asnB-2COG0367 Asparagine synthase (glutamine-hydrolyzing). (622 aa)
dapBCOG0289 Dihydrodipicolinate reductase; Belongs to the DapB family. (242 aa)
lysCCOG0527 Aspartokinases; Belongs to the aspartokinase family. (424 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
mtnDMethionine salvage pathway protein E-2/E-2'; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (175 aa)
SGRA_2872Asparaginase/glutaminase; COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D. (173 aa)
sucB2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1225 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
mtnC2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (226 aa)
SGRA_1115M20/M25/M40 family peptidase; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (462 aa)
mtnNPurine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (227 aa)
hipON-acyl-L-amino acid amidohydrolase; COG1473 Metal-dependent amidase/aminoacylase/carboxypeptidase. (398 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (265 aa)
metFCOG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
thrBCOG0083 Homoserine kinase. (303 aa)
dapDCOG2171 Tetrahydrodipicolinate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (271 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (413 aa)
asnBCOG0367 Asparagine synthase (glutamine-hydrolyzing). (635 aa)
SGRA_2422Peptidase M20; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (451 aa)
mtnAPutative translation initiation factor eIF-2B alpha subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (366 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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