node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SGRA_0564 | gmk | SGRA_0564 | SGRA_3886 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.568 |
SGRA_0564 | prsA | SGRA_0564 | SGRA_1543 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.430 |
SGRA_0798 | purA | SGRA_0798 | SGRA_0697 | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.570 |
SGRA_0798 | purE | SGRA_0798 | SGRA_3653 | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.721 |
SGRA_0798 | upp | SGRA_0798 | SGRA_2526 | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). | COG0035 Uracil phosphoribosyltransferase. | 0.433 |
SGRA_1579 | purA | SGRA_1579 | SGRA_0697 | Formyl transferase domain protein; COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.537 |
SGRA_1579 | purE | SGRA_1579 | SGRA_3653 | Formyl transferase domain protein; COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.962 |
SGRA_1579 | purK | SGRA_1579 | SGRA_3654 | Formyl transferase domain protein; COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.959 |
adk | gmk | SGRA_0637 | SGRA_3886 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.720 |
adk | hpt | SGRA_0637 | SGRA_4006 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.931 |
adk | purA | SGRA_0637 | SGRA_0697 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.472 |
adk | surE | SGRA_0637 | SGRA_3190 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.913 |
gmk | SGRA_0564 | SGRA_3886 | SGRA_0564 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | 0.568 |
gmk | adk | SGRA_3886 | SGRA_0637 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.720 |
gmk | hpt | SGRA_3886 | SGRA_4006 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.933 |
gmk | prsA | SGRA_3886 | SGRA_1543 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.743 |
gmk | purA | SGRA_3886 | SGRA_0697 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.438 |
gmk | surE | SGRA_3886 | SGRA_3190 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.920 |
gmk | udk | SGRA_3886 | SGRA_1088 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | COG0572 Uridine kinase. | 0.400 |
hpt | adk | SGRA_4006 | SGRA_0637 | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.931 |