STRINGSTRING
upp upp pyk pyk SGRA_2351 SGRA_2351 SGRA_2347 SGRA_2347 atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB SGRA_2249 SGRA_2249 coaE coaE atpD atpD atpC atpC pfk pfk SGRA_1936 SGRA_1936 SGRA_1859 SGRA_1859 pyrH pyrH SGRA_1579 SGRA_1579 SGRA_1576 SGRA_1576 pdhA pdhA mvaD mvaD relA relA udk udk coaX coaX SGRA_0798 SGRA_0798 SGRA_0742 SGRA_0742 SGRA_0713 SGRA_0713 purA purA prpE prpE accD accD adk adk eno eno SGRA_0564 SGRA_0564 dacA dacA pyrG pyrG fbaB fbaB SGRA_4190 SGRA_4190 coaD coaD hpt hpt pgk pgk gmk gmk mazG mazG ndk ndk sucB-2 sucB-2 purK purK purE purE acs acs SGRA_3436 SGRA_3436 manA manA accA accA gpm gpm surE surE SGRA_3170 SGRA_3170 aceF aceF tpiA tpiA sucB sucB SGRA_2545 SGRA_2545 pdhB pdhB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uppCOG0035 Uracil phosphoribosyltransferase. (219 aa)
pykCOG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
SGRA_2351WbqC-like family protein. (210 aa)
SGRA_2347Metal dependent phosphohydrolase; COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases. (186 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (301 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (534 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (186 aa)
atpFATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (173 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (64 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (421 aa)
SGRA_2249COG1257 Hydroxymethylglutaryl-CoA reductase. (515 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (502 aa)
atpCH+-transporting two-sector ATPase, epsilon subunit; COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit). (79 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
SGRA_19363-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (665 aa)
SGRA_1859Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (128 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
SGRA_1579Formyl transferase domain protein; COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. (226 aa)
SGRA_1576WbqC-like family protein. (229 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (335 aa)
mvaDCOG3407 Mevalonate pyrophosphate decarboxylase. (347 aa)
relA(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (765 aa)
udkCOG0572 Uridine kinase. (209 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (247 aa)
SGRA_0798COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (286 aa)
SGRA_0742Glutamate-rich protein grpB. (177 aa)
SGRA_0713Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (172 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (422 aa)
prpEprpE protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (627 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
SGRA_0564Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (315 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (256 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
fbaBCOG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa)
SGRA_4190COG1607 Acyl-CoA hydrolase. (163 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
hptCOG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa)
pgkCOG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (403 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
mazGNucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. (254 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
sucB-2Catalytic domain of components of various dehydrogenase complexes; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (441 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa)
acsAcetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa)
SGRA_3436hydroxymethylglutaryl-CoA reductase, degradative; COG1257 Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (460 aa)
manABifunctional phosphoglucose/phosphomannose isomerase; COG0166 Glucose-6-phosphate isomerase. (330 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
surE5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
SGRA_3170Glyoxalase/bleomycin resistance protein/dioxygenase; COG3324 Predicted enzyme related to lactoylglutathione lyase. (120 aa)
aceFPyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (417 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
sucB2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa)
SGRA_2545Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
pdhBTransketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.