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| | mcrB | ATPase associated with various cellular activities AAA_5; COG1401 GTPase subunit of restriction endonuclease. (549 aa) |
| | ruvX | Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (171 aa) |
| | astE | Succinylglutamate desuccinylase/aspartoacylase family protein; COG2988 Succinylglutamate desuccinylase. (333 aa) |
| | uvrC | Uvrabc system protein c; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (603 aa) |
| | SGRA_1355 | Smr protein/MutS2; COG1193 Mismatch repair ATPase (MutS family). (365 aa) |
| | recJ | COG0608 Single-stranded DNA-specific exonuclease. (564 aa) |
| | glpQ | COG0584 Glycerophosphoryl diester phosphodiesterase. (324 aa) |
| | SGRA_1446 | Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (468 aa) |
| | SGRA_1465 | Arsenate reductase; COG0394 Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (196 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1123 aa) |
| | dnaQ-2 | COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (248 aa) |
| | SGRA_1654 | Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (339 aa) |
| | suhB | Inositol monophosphatase; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (268 aa) |
| | rnpA | Ribonuclease p protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (133 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (263 aa) |
| | uvrB | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (680 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (152 aa) |
| | SGRA_1859 | Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (128 aa) |
| | dnaN | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (901 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (177 aa) |
| | uvrD | COG0210 Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1069 aa) |
| | holB | COG2812 DNA polymerase III, gamma/tau subunits. (385 aa) |
| | rnhA | Putative ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase H family. (209 aa) |
| | uvrA | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa) |
| | ybeY | Hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (145 aa) |
| | SGRA_2273 | COG3440 Predicted restriction endonuclease. (292 aa) |
| | SGRA_2279 | COG0394 Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (150 aa) |
| | SGRA_2361 | Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (216 aa) |
| | uvrA-2 | UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (930 aa) |
| | mtnC | 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (226 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (252 aa) |
| | SGRA_2513 | GSCFA family protein. (326 aa) |
| | rng | COG1530 Ribonucleases G and E. (520 aa) |
| | rnhB | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (205 aa) |
| | xthA | Exodeoxyribonuclease III Xth; COG0708 Exonuclease III. (257 aa) |
| | mutS2 | MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa) |
| | SGRA_2608 | Sigma factor regulation protein; COG2203 FOG: GAF domain. (432 aa) |
| | SGRA_2753 | Hypothetical protein. (954 aa) |
| | rny | Phosphodiesterase; Endoribonuclease that initiates mRNA decay. (545 aa) |
| | SGRA_2826 | Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (297 aa) |
| | SGRA_2865 | Putative lipoprotein. (310 aa) |
| | ebsC | ybaK/ebsC protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (157 aa) |
| | SGRA_2983 | COG1403 Restriction endonuclease. (217 aa) |
| | SGRA_3136 | 3'-5' exonuclease; COG0349 Ribonuclease D. (194 aa) |
| | sixA | COG2062 Phosphohistidine phosphatase SixA. (183 aa) |
| | SGRA_3155 | COG1864 DNA/RNA endonuclease G, NUC1. (269 aa) |
| | surE | 5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa) |
| | rsbU | COG2208 Serine phosphatase RsbU, regulator of sigma subunit. (542 aa) |
| | cheB | Protein-glutamate methylesterase, two-component response regulator, chemotaxis; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa) |
| | SGRA_3396 | 5 nucleotidase deoxy cytosolic type C; COG4502 Uncharacterized protein conserved in bacteria. (149 aa) |
| | dnaE | COG0587 DNA polymerase III, alpha subunit. (1176 aa) |
| | SGRA_3455 | COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (206 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (927 aa) |
| | SGRA_3594 | Hypothetical protein. (289 aa) |
| | SGRA_3611 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. (319 aa) |
| | SGRA_3640 | COG2356 Endonuclease I. (362 aa) |
| | SGRA_3684 | Peptidase C14, caspase catalytic subunit p20. (977 aa) |
| | SGRA_3697 | CRISPR-associated protein Cas6; COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (273 aa) |
| | SGRA_3736 | Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. (1481 aa) |
| | SGRA_3748 | Hypothetical protein; COG3150 Predicted esterase. (161 aa) |
| | xseA | COG1570 Exonuclease VII, large subunit; Belongs to the XseA family. (399 aa) |
| | SGRA_3845 | Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (461 aa) |
| | SGRA_3870 | Hypothetical protein; COG0481 Membrane GTPase LepA. (299 aa) |
| | SGRA_3885 | Hypothetical protein; COG1561 Uncharacterized stress-induced protein. (287 aa) |
| | SGRA_3895 | Hypothetical protein; COG1403 Restriction endonuclease. (316 aa) |
| | hsdR-3 | Type I restriction-modification system, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1070 aa) |
| | leuS | COG0495 Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (939 aa) |
| | ybgC-2 | COG0824 Predicted thioesterase. (139 aa) |
| | SGRA_4128 | COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (1036 aa) |
| | SGRA_4129 | Hypothetical protein. (137 aa) |
| | SGRA_4130 | Hypothetical protein. (235 aa) |
| | SGRA_4155 | Esterase; COG0824 Predicted thioesterase. (144 aa) |
| | SGRA_4190 | COG1607 Acyl-CoA hydrolase. (163 aa) |
| | SGRA_4226 | Metallophosphoesterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. (319 aa) |
| | dnaQ | COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases. (267 aa) |
| | SGRA_0100 | COG4268 McrBC 5-methylcytosine restriction system component. (398 aa) |
| | SGRA_0215 | CRISPR-associated RAMP Csm3 family protein; COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (248 aa) |
| | SGRA_0217 | CRISPR-associated protein, Csm1 family; COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs). (903 aa) |
| | kdsC | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; COG1778 Low specificity phosphatase (HAD superfamily). (174 aa) |
| | SGRA_0275 | COG1343 Uncharacterized protein predicted to be involved in DNA repair. (98 aa) |
| | cas1 | CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (321 aa) |
| | hsdR | Type I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (936 aa) |
| | SGRA_0305 | COG4268 McrBC 5-methylcytosine restriction system component. (408 aa) |
| | SGRA_0306 | TPR repeat-containing protein; COG1401 GTPase subunit of restriction endonuclease. (825 aa) |
| | nfi | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (229 aa) |
| | SGRA_0330 | 3-5 exonuclease eri-1; COG5018 Inhibitor of the KinA pathway to sporulation, predicted exonuclease. (183 aa) |
| | SGRA_0394 | Hypothetical protein. (210 aa) |
| | SGRA_0395 | Hypothetical protein; COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component. (94 aa) |
| | SGRA_0443 | Hypothetical protein; COG1512 Beta-propeller domains of methanol dehydrogenase type. (272 aa) |
| | SGRA_0448 | CRISPR-associated protein, TM1812 family. (441 aa) |
| | SGRA_0450 | CRISPR-associated protein, TM1812 family. (407 aa) |
| | SGRA_0453 | CRISPR-associated RAMP protein; COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (558 aa) |
| | SGRA_0455 | COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (194 aa) |
| | SGRA_0456 | Hypothetical protein. (591 aa) |
| | SGRA_0476 | Hypothetical protein. (229 aa) |
| | SGRA_0497 | COG0631 Serine/threonine protein phosphatase. (293 aa) |
| | SGRA_0544 | Hypothetical protein; COG1512 Beta-propeller domains of methanol dehydrogenase type. (328 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (304 aa) |
| | tatD | Hydrolase, TatD family protein; COG0084 Mg-dependent DNase. (272 aa) |
| | SGRA_0674 | LamG domain protein jellyroll fold domain protein. (496 aa) |
| | SGRA_0713 | Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (172 aa) |
| | rnr | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (986 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa) |
| | SGRA_0860 | Hypothetical protein. (196 aa) |
| | phoD | COG3540 Phosphodiesterase/alkaline phosphatase D. (422 aa) |
| | SGRA_0927 | Hypothetical protein; COG1512 Beta-propeller domains of methanol dehydrogenase type. (269 aa) |
| | SGRA_0928 | Putative membrane protein; COG1512 Beta-propeller domains of methanol dehydrogenase type. (318 aa) |
| | SGRA_0932 | CRISPR-associated protein, putative. (120 aa) |
| | SGRA_0949 | COG1722 Exonuclease VII small subunit. (65 aa) |
| | recQ | ATP-dependent DNA helicase, RecQ family protein; COG0514 Superfamily II DNA helicase. (2930 aa) |
| | pth | peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (226 aa) |
| | ybgC | Thioesterase-like protein; COG0824 Predicted thioesterase. (153 aa) |
| | SGRA_1023 | RNA-directed DNA polymerase; COG3344 Retron-type reverse transcriptase. (554 aa) |
| | SGRA_1027 | COG1864 DNA/RNA endonuclease G, NUC1. (410 aa) |
| | fbp | COG0158 Fructose-1,6-bisphosphatase. (327 aa) |
