24 items (Saprospira grandis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	amiA	Cell wall hydrolase/autolysin; COG0860 N-acetylmuramoyl-L-alanine amidase. (367 aa)
	pyrG	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
	SGRA_0737	Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (183 aa)
	SGRA_0910	COG2366 Protein related to penicillin acylase. (684 aa)
	SGRA_1068	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein. (300 aa)
	def	Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (185 aa)
	astE	Succinylglutamate desuccinylase/aspartoacylase family protein; COG2988 Succinylglutamate desuccinylase. (333 aa)
	flgJ	COG1705 Muramidase (flagellum-specific). (202 aa)
	SGRA_1236	COG2120 Uncharacterized proteins, LmbE homologs. (238 aa)
	SGRA_1500	mannosyL-glycoprotein endO-beta-N-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (335 aa)
	lpxC	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa)
	SGRA_1665	Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (534 aa)
	SGRA_1933	Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (312 aa)
	SGRA_2082	Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (346 aa)
	SGRA_2247	COG2120 Uncharacterized proteins, LmbE homologs. (237 aa)
	flgJ-2	Mannosyl-glycoprotein endo-beta-n-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (477 aa)
	SGRA_2600	Peptidase S45 penicillin amidase; COG2366 Protein related to penicillin acylase. (840 aa)
	SGRA_2872	Asparaginase/glutaminase; COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D. (173 aa)
	cheB	Protein-glutamate methylesterase, two-component response regulator, chemotaxis; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
	nadE	NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (545 aa)
	SGRA_3474	N-formylkynurenine (aryl-) formamidase. (254 aa)
	cobB	COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily. (232 aa)
	SGRA_4174	Cell wall hydrolase/autolysin; COG0860 N-acetylmuramoyl-L-alanine amidase. (385 aa)
	SGRA_4209	Cyclase family protein; COG1878 Predicted metal-dependent hydrolase. (256 aa)

Your Current Organism:

Saprospira grandis

NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SGRA_1068	cobB	SGRA_1068	SGRA_3962	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein.	COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily.	0.640
SGRA_4174	amiA	SGRA_4174	SGRA_2055	Cell wall hydrolase/autolysin; COG0860 N-acetylmuramoyl-L-alanine amidase.	Cell wall hydrolase/autolysin; COG0860 N-acetylmuramoyl-L-alanine amidase.	0.900
amiA	SGRA_4174	SGRA_2055	SGRA_4174	Cell wall hydrolase/autolysin; COG0860 N-acetylmuramoyl-L-alanine amidase.	Cell wall hydrolase/autolysin; COG0860 N-acetylmuramoyl-L-alanine amidase.	0.900
cobB	SGRA_1068	SGRA_3962	SGRA_1068	COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily.	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein.	0.640
cobB	nadE	SGRA_3962	SGRA_3361	COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily.	NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.947
nadE	cobB	SGRA_3361	SGRA_3962	NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily.	0.947
nadE	pyrG	SGRA_3361	SGRA_0168	NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	0.406
pyrG	nadE	SGRA_0168	SGRA_3361	CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.	NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.	0.406