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queE queE SGRA_1066 SGRA_1066 gadB gadB speA speA ribBA ribBA nth nth ltaA ltaA ilvA ilvA hemB hemB ptpS-2 ptpS-2 SGRA_3780 SGRA_3780 mqnA mqnA acnA acnA purK purK pabB pabB gmd gmd phrB-2 phrB-2 hemE hemE dapA dapA argH argH psd psd SGRA_3134 SGRA_3134 folB folB aroB aroB metC metC ebsC ebsC SGRA_2877 SGRA_2877 aroQ aroQ SGRA_2545 SGRA_2545 cah cah SGRA_2370 SGRA_2370 aroC aroC phhB phhB lysA lysA mltD mltD mtnB mtnB SGRA_2015 SGRA_2015 ptpS ptpS SGRA_2001 SGRA_2001 mqnD mqnD SGRA_0693 SGRA_0693 eno eno panD panD pckA pckA hemH hemH nnrE nnrE SGRA_0460 SGRA_0460 dacA dacA speE speE mltG mltG fbaB fbaB ubiD ubiD deoC deoC SGRA_1751 SGRA_1751 rfbB rfbB sdaA-2 sdaA-2 hutU hutU hemD hemD lpxC lpxC fumC fumC thiC thiC SGRA_1434 SGRA_1434 sdaA sdaA fabZ fabZ cynT cynT hutH hutH SGRA_1374 SGRA_1374 talA talA phrB phrB mvaD mvaD SGRA_1103 SGRA_1103
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
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queERadical SAM family protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (255 aa)
SGRA_1066COG2324 Predicted membrane protein. (222 aa)
gadBCOG0076 Glutamate decarboxylase and related PLP-dependent proteins. (483 aa)
speAOrn/DAP/Arg decarboxylase 2; COG1166 Arginine decarboxylase (spermidine biosynthesis). (465 aa)
ribBAGtp cyclohydrolase ii; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (415 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
ltaACOG2008 Threonine aldolase. (338 aa)
ilvAPyridoxal-5'-phosphate-dependent protein beta subunit; COG1171 Threonine dehydratase. (319 aa)
hemBCOG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (333 aa)
ptpS-2COG0720 6-pyruvoyl-tetrahydropterin synthase. (138 aa)
SGRA_3780Hypothetical protein. (766 aa)
mqnAHypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (256 aa)
acnAAconitate hydratase; COG1048 Aconitase A. (759 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa)
pabBChorismate binding protein; COG0147 Anthranilate/para-aminobenzoate synthases component I. (429 aa)
gmdPutative GDP-D-mannose dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (331 aa)
phrB-2COG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (445 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (342 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
argHCOG0165 Argininosuccinate lyase. (445 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (293 aa)
SGRA_3134Hypothetical protein; COG0804 Urea amidohydrolase (urease) alpha subunit. (490 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (174 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
metCCOG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (379 aa)
ebsCybaK/ebsC protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (157 aa)
SGRA_2877Vitamin k-dependent gamma-carboxylase-like protein. (428 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
SGRA_2545Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
cahCOG3338 Carbonic anhydrase. (281 aa)
SGRA_2370COG0076 Glutamate decarboxylase and related PLP-dependent proteins. (485 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa)
phhBTranscriptional coactivator/pterin dehydratase; COG2154 Pterin-4a-carbinolamine dehydratase. (87 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (413 aa)
mltDCOG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). (600 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (224 aa)
SGRA_2015Porphobilinogen deaminase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (221 aa)
ptpSCOG0720 6-pyruvoyl-tetrahydropterin synthase. (138 aa)
SGRA_2001Putative secreted protein containing cyclophilin type peptidyl-prolyl cis-trans isomerase domain; COG1413 FOG: HEAT repeat. (680 aa)
mqnDHypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (273 aa)
SGRA_0693Hypothetical protein. (126 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (115 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (340 aa)
nnrEPutative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] (517 aa)
SGRA_0460Vitamin K-dependent gamma-carboxylase. (434 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (256 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (399 aa)
mltGAminodeoxychorismate lyase family protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (353 aa)
fbaBCOG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes. (350 aa)
ubiDUbiD family decarboxylase; COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Belongs to the UbiD family. (610 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa)
SGRA_1751Hypothetical protein. (256 aa)
rfbBCOG1088 dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (351 aa)
sdaA-2COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (482 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (672 aa)
hemDuroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (262 aa)
lpxC3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa)
fumCFumarate hydratase, class ii; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa)
SGRA_1434COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (389 aa)
sdaACOG1171 Threonine dehydratase. (301 aa)
fabZ(3R)-hydroxymyristoyl-[acyl-carrier- protein]dehydratase; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases. (153 aa)
cynTCarbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (196 aa)
hutHCOG2986 Histidine ammonia-lyase. (500 aa)
SGRA_1374Hypothetical protein. (137 aa)
talAPutative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa)
phrBCOG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (466 aa)
mvaDCOG3407 Mevalonate pyrophosphate decarboxylase. (347 aa)
SGRA_1103Vitamin k-dependent gamma-carboxylase. (440 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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