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crt crt manB-2 manB-2 truA truA apaG apaG hemL hemL purE purE fcl fcl rpe rpe aroA-2 aroA-2 rluD-3 rluD-3 manA manA gpm gpm gyrB gyrB manB manB rluD-2 rluD-2 tpiA tpiA alr alr SGRA_2913 SGRA_2913 surA-2 surA-2 SGRA_2576 SGRA_2576 SGRA_2524 SGRA_2524 mtnC mtnC mtnA mtnA SGRA_2276 SGRA_2276 ppiB-2 ppiB-2 galE-2 galE-2 hisA hisA surA surA SGRA_1955 SGRA_1955 icmF icmF SGRA_1806 SGRA_1806 ppiD ppiD SGRA_1745 SGRA_1745 rluD rluD parE parE SGRA_1480 SGRA_1480 SGRA_1444 SGRA_1444 tig tig dapF dapF SGRA_1359 SGRA_1359 SGRA_1352 SGRA_1352 ppiB ppiB SGRA_1085 SGRA_1085 truC truC rluF rluF rfbC rfbC parC parC topA topA truB truB fklB-4 fklB-4 fklB-3 fklB-3 fklB-2 fklB-2 fklB fklB SGRA_0710 SGRA_0710 gyrA gyrA rluB rluB rpiB rpiB murI murI groEL groEL rluE rluE queA queA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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crtCOG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
manB-2COG1109 Phosphomannomutase. (467 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (264 aa)
apaGCo2+/Mg2+ efflux protein ApaG; COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport. (129 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. (428 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa)
fclGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (301 aa)
rpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
aroA-2Dahp synthetase i/kdsa; COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase. (373 aa)
rluD-3Pseudouridine synthase, RluA family protein; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (345 aa)
manABifunctional phosphoglucose/phosphomannose isomerase; COG0166 Glucose-6-phosphate isomerase. (330 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (658 aa)
manBCOG1109 Phosphomannomutase. (463 aa)
rluD-2Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (245 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (257 aa)
alrPutative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (812 aa)
SGRA_2913Lycopene cyclase domain protein. (292 aa)
surA-2COG0760 Parvulin-like peptidyl-prolyl isomerase. (660 aa)
SGRA_2576COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (361 aa)
SGRA_2524COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1. (149 aa)
mtnC2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (226 aa)
mtnAPutative translation initiation factor eIF-2B alpha subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (366 aa)
SGRA_2276KpsF/GutQ family protein; COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Belongs to the SIS family. GutQ/KpsF subfamily. (314 aa)
ppiB-2COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family. (240 aa)
galE-2COG1087 UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (347 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (241 aa)
surACOG0760 Parvulin-like peptidyl-prolyl isomerase. (460 aa)
SGRA_1955Hypothetical protein. (285 aa)
icmFmethylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1119 aa)
SGRA_1806COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (713 aa)
ppiDCOG0760 Parvulin-like peptidyl-prolyl isomerase. (732 aa)
SGRA_1745N-(5'phosphoribosyl)anthranilate isomerase (PRAI). (208 aa)
rluDRibosomal large subunit pseudouridine synthase d; COG0564 Pseudouridylate synthases, 23S RNA-specific. (241 aa)
parEDNA topoisomerase IV subunit B; COG0187 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit. (616 aa)
SGRA_1480COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1. (346 aa)
SGRA_1444Hypothetical protein. (98 aa)
tigTrigger factor; COG0544 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor). (467 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (265 aa)
SGRA_1359Maf-like protein. (269 aa)
SGRA_1352COG3457 Predicted amino acid racemase. (358 aa)
ppiBCOG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family. (243 aa)
SGRA_1085Transmembrane prediction. (237 aa)
truCCOG0564 Pseudouridylate synthases, 23S RNA-specific. (296 aa)
rluFPutative ribosomal RNA pseudouridine synthase; COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (234 aa)
rfbCdTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa)
parCCOG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. (839 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (876 aa)
truBtRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (241 aa)
fklB-4COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1. (242 aa)
fklB-3COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1. (321 aa)
fklB-2COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1. (239 aa)
fklBCOG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1. (196 aa)
SGRA_0710COG0545 FKBP-type peptidyl-prolyl cis-trans isomerases 1. (152 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (858 aa)
rluBPseudouridine synthase; COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (270 aa)
rpiBCOG0698 Ribose 5-phosphate isomerase RpiB. (149 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (278 aa)
groELChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (546 aa)
rluEPseudouridine synthase; COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. (199 aa)
queAS-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (352 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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