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| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (376 aa) |
| | cinA | Competence/damage-inducible protein CinA; COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Belongs to the CinA family. (419 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (262 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (352 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | ribE | COG0307 Riboflavin synthase alpha chain. (198 aa) |
| | SGRA_0122 | COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (435 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa) |
| | SGRA_0197 | RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa) |
| | SGRA_0400 | AAA ATPase. (287 aa) |
| | SGRA_0401 | SMC domain protein; COG3950 Predicted ATP-binding protein involved in virulence. (532 aa) |
| | SGRA_0403 | AAA ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (440 aa) |
| | dacA | Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (256 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (340 aa) |
| | SGRA_0564 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (315 aa) |
| | dpx | PHP domain protein; COG1796 DNA polymerase IV (family X). (556 aa) |
| | rpoE | RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (172 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (192 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | prpE | prpE protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (627 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (422 aa) |
| | add | COG1816 Adenosine deaminase. (431 aa) |
| | rpoE-2 | RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa) |
| | SGRA_0742 | Glutamate-rich protein grpB. (177 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (839 aa) |
| | rpoD | RNA polymerase, sigma 70 subunit, RpoD subfamily protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (290 aa) |
| | SGRA_0798 | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (286 aa) |
| | SGRA_0832 | COG4245 Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain. (383 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (247 aa) |
| | ribBA | Gtp cyclohydrolase ii; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (415 aa) |
| | rfbD | Putative dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (292 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | SGRA_0925 | Polysaccharide biosynthesis protein; COG0417 DNA polymerase elongation subunit (family B). (140 aa) |
| | ppnK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (803 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase small chain; COG0208 Ribonucleotide reductase, beta subunit. (323 aa) |
| | hemN | Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (349 aa) |
| | SGRA_1023 | RNA-directed DNA polymerase; COG3344 Retron-type reverse transcriptase. (554 aa) |
| | rpoE-3 | RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (152 aa) |
| | rpoE-4 | RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa) |
| | queE | Radical SAM family protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (255 aa) |
| | udk | COG0572 Uridine kinase. (209 aa) |
| | SGRA_1114 | Cobalamin synthesis protein CobW; COG0523 Putative GTPases (G3E family). (332 aa) |
| | SGRA_1121 | Hypothetical protein. (187 aa) |
| | SGRA_1122 | Hypothetical protein. (249 aa) |
| | rpoE-11 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (201 aa) |
| | nusA | Transcription elongation factor NusA; Participates in both transcription termination and antitermination. (438 aa) |
| | SGRA_1151 | Nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (399 aa) |
| | SGRA_1226 | Von Willebrand factor type A; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (333 aa) |
| | SGRA_1227 | Von Willebrand factor type A; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (336 aa) |
| | SGRA_1252 | Glycosyl transferase group 1; COG0535 Predicted Fe-S oxidoreductases. (341 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (593 aa) |
| | pdhA | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (335 aa) |
| | SGRA_1372 | Cobalamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (185 aa) |
| | SGRA_1373 | COG1981 Predicted membrane protein. (188 aa) |
| | SGRA_1375 | RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa) |
| | SGRA_1449 | COG2104 Sulfur transfer protein involved in thiamine biosynthesis. (90 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (218 aa) |
| | thiD | COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (253 aa) |
| | thiE-2 | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa) |
| | SGRA_1493 | TPR repeat-containing protein; COG0457 FOG: TPR repeat. (563 aa) |
| | cyoE | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (277 aa) |
| | prsA | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa) |
| | SGRA_1576 | WbqC-like family protein. (229 aa) |
| | SGRA_1579 | Formyl transferase domain protein; COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. (226 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa) |
| | rpoE-5 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (213 aa) |
| | rpoE-6 | RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (175 aa) |
| | nadC | COG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (285 aa) |
| | rpoS | Putative RNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (290 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (213 aa) |
| | thiH | COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (381 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (589 aa) |
| | hemD | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (262 aa) |
| | phnP | COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I. (254 aa) |
| | ugd | Nucleotide sugar dehydrogenase; COG1004 Predicted UDP-glucose 6-dehydrogenase. (440 aa) |
| | SGRA_1732 | RNA polymerase, sigma-E factor; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa) |
| | SGRA_1745 | N-(5'phosphoribosyl)anthranilate isomerase (PRAI). (208 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (683 aa) |
| | rpoE-7 | RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (335 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (332 aa) |
| | dnaN | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | serA-2 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (340 aa) |
| | elaA | GCN5-like N-acetyltransferase; COG2153 Predicted acyltransferase. (153 aa) |
| | atpC | H+-transporting two-sector ATPase, epsilon subunit; COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit). (79 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | ptpS | COG0720 6-pyruvoyl-tetrahydropterin synthase. (138 aa) |
| | SGRA_2011 | HAD-superfamily hydrolase, subfamily IA, variant 3; COG1011 Predicted hydrolase (HAD superfamily). (215 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa) |
| | SGRA_2015 | Porphobilinogen deaminase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (221 aa) |
| | SGRA_2020 | Thiamine S protein; COG1977 Molybdopterin converting factor, small subunit. (93 aa) |
| | SGRA_2036 | Cytochrome oxidase assembly; COG1612 Uncharacterized protein required for cytochrome oxidase assembly. (383 aa) |
| | holB | COG2812 DNA polymerase III, gamma/tau subunits. (385 aa) |
| | queG | Iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (309 aa) |
| | phhB | Transcriptional coactivator/pterin dehydratase; COG2154 Pterin-4a-carbinolamine dehydratase. (87 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (223 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. (517 aa) |
| | SGRA_2285 | RNA polymerase sigma factor, sigma-70 family protein; COG1191 DNA-directed RNA polymerase specialized sigma subunit. (199 aa) |
| | nusG | NusG antitermination factor; Participates in transcription elongation, termination and antitermination. (180 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1276 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1420 aa) |
| | SGRA_2318 | Galanin. (302 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (421 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (64 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (173 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (186 aa) |
| | atpA | F0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (534 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (301 aa) |
| | SGRA_2351 | WbqC-like family protein. (210 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (466 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (298 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa) |
| | SGRA_2395 | ECF subfamily RNA polymerase sigma-24 factor; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa) |
| | rpoE-8 | RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa) |
| | rpoE-9 | COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa) |
| | serC | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (355 aa) |
| | upp | COG0035 Uracil phosphoribosyltransferase. (219 aa) |
| | pdhB | Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa) |
| | SGRA_2545 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa) |
| | SGRA_2546 | DNA-directed RNA polymerase, omega subunit. (113 aa) |
| | SGRA_2572 | SMC domain protein; COG4637 Predicted ATPase. (454 aa) |
| | SGRA_2578 | Von Willebrand factor type A; COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain. (550 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (162 aa) |
| | SGRA_2628 | COG1428 Deoxynucleoside kinases. (219 aa) |
| | sprA | Gliding motility protein SprA. (2512 aa) |
| | dnaB | Primary replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (510 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (175 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (239 aa) |
| | SGRA_2901 | Hypothetical protein; COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA. (678 aa) |
| | dcd | COG0717 Deoxycytidine deaminase. (178 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (284 aa) |
| | SGRA_2984 | AAA ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (399 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (296 aa) |
| | SGRA_2997 | Galanin. (331 aa) |
| | SGRA_3004 | Radical SAM domain protein; COG0535 Predicted Fe-S oxidoreductases. (344 aa) |
| | SGRA_3027 | Regulatory protein (nitrile hydratase activator like); COG0523 Putative GTPases (G3E family). (401 aa) |
| | SGRA_3037 | SMC domain protein; COG1122 ABC-type cobalt transport system, ATPase component. (620 aa) |
| | SGRA_3038 | Hypothetical protein; COG1403 Restriction endonuclease. (319 aa) |
| | rfbD-2 | COG1091 dTDP-4-dehydrorhamnose reductase. (295 aa) |
| | aceF | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (417 aa) |
| | SGRA_3095 | Riboflavin biosynthesis protein ribd; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (348 aa) |
| | folA | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (175 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (174 aa) |
| | SGRA_3138 | Hypothetical protein. (509 aa) |
| | SGRA_3156 | Hypothetical protein. (473 aa) |
| | SGRA_3217 | Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (266 aa) |
| | rpoN | COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog. (539 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (484 aa) |
| | SGRA_3257 | Hypothetical protein; COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components. (371 aa) |
| | holA | COG1466 DNA polymerase III, delta subunit. (356 aa) |
| | rpoE-10 | RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa) |
| | folE | COG0302 GTP cyclohydrolase I. (231 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa) |
| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (545 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (342 aa) |
| | SGRA_3404 | ATPase-like protein; COG4637 Predicted ATPase. (354 aa) |
| | dnaE | COG0587 DNA polymerase III, alpha subunit. (1176 aa) |
| | acs | Acetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa) |
| | SGRA_3526 | COG0262 Dihydrofolate reductase. (176 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (927 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (439 aa) |
| | fcl | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (301 aa) |
| | SGRA_3606 | Hypothetical protein. (429 aa) |
| | nusB | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (311 aa) |
| | SGRA_3652 | Hypothetical protein. (194 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa) |
| | SGRA_3662 | Hypothetical protein. (278 aa) |
| | SGRA_3663 | Hypothetical protein. (270 aa) |
| | SGRA_3668 | Galanin; COG0556 Helicase subunit of the DNA excision repair complex. (323 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa) |
| | SGRA_3716 | Hypothetical protein; COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (181 aa) |
| | hemL | Glutamate-1-semialdehyde-2,1-aminomutase; COG0001 Glutamate-1-semialdehyde aminotransferase. (428 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (330 aa) |
| | SGRA_3733 | COG1428 Deoxynucleoside kinases. (210 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (238 aa) |
| | tdk | COG1435 Thymidine kinase. (184 aa) |
| | cmk | COG0283 Cytidylate kinase. (237 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (191 aa) |
| | SGRA_3869 | SMC domain-containing protein; COG3950 Predicted ATP-binding protein involved in virulence. (433 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | apaG | Co2+/Mg2+ efflux protein ApaG; COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport. (129 aa) |
| | SGRA_3894 | SMC domain-containing protein; COG3950 Predicted ATP-binding protein involved in virulence. (441 aa) |
| | bioA | COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa) |
| | SGRA_3981 | Hypothetical protein. (223 aa) |
| | hpt | COG0634 Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (184 aa) |
| | SGRA_4016 | Hypothetical protein. (686 aa) |
| | rocD | COG4992 Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | hemF | COG0408 Coproporphyrinogen III oxidase. (308 aa) |
| | ptpS-2 | COG0720 6-pyruvoyl-tetrahydropterin synthase. (138 aa) |
| | SGRA_4131 | ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (751 aa) |
| | hemB | COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (333 aa) |
