STRINGSTRING
eno eno SGRA_4226 SGRA_4226 SGRA_4209 SGRA_4209 SGRA_4195 SGRA_4195 SGRA_4151 SGRA_4151 hemB hemB ptpS-2 ptpS-2 manB-2 manB-2 SGRA_4095 SGRA_4095 hemF hemF thrS thrS rocF rocF SGRA_3989 SGRA_3989 SGRA_3976 SGRA_3976 SGRA_3933 SGRA_3933 dps-2 dps-2 bioA bioA apaG apaG katE-2 katE-2 SGRA_3842 SGRA_3842 dut dut SGRA_3832 SGRA_3832 sfcA sfcA SGRA_3819 SGRA_3819 SGRA_3797 SGRA_3797 tdk tdk SGRA_3772 SGRA_3772 hmgA hmgA bioB bioB mqnE mqnE SGRA_3716 SGRA_3716 ndk ndk sucC sucC SGRA_3668 SGRA_3668 acnA acnA lemA lemA purK purK SGRA_3624 SGRA_3624 SGRA_3613 SGRA_3613 gshB gshB SGRA_3611 SGRA_3611 SGRA_3562 SGRA_3562 sms sms rpe rpe SGRA_3458 SGRA_3458 acs acs aroK aroK SGRA_3396 SGRA_3396 ppk ppk pepF pepF ligA ligA folE folE gpm gpm clpX clpX SGRA_3271 SGRA_3271 manB manB surE surE SGRA_3188 SGRA_3188 metG metG SGRA_3155 SGRA_3155 SGRA_3148 SGRA_3148 recR recR SGRA_3143 SGRA_3143 SGRA_3139 SGRA_3139 apbE-2 apbE-2 SGRA_3095 SGRA_3095 rfbA-2 rfbA-2 dps dps nqrF nqrF mtnD mtnD aroB aroB SGRA_3030 SGRA_3030 SGRA_3005 SGRA_3005 SGRA_3004 SGRA_3004 SGRA_2999 SGRA_2999 SGRA_2998 SGRA_2998 SGRA_2997 SGRA_2997 lipA lipA SGRA_2977 SGRA_2977 SGRA_2890 SGRA_2890 troR troR vanX vanX SGRA_2861 SGRA_2861 SGRA_2850 SGRA_2850 pepT pepT SGRA_2826 SGRA_2826 SGRA_2812 SGRA_2812 cdd cdd pepN pepN alaS alaS pheT pheT copA copA icd-2 icd-2 SGRA_2767 SGRA_2767 SGRA_2764 SGRA_2764 SGRA_2736 SGRA_2736 rsgA rsgA pcrB pcrB SGRA_2707 SGRA_2707 SGRA_2706 SGRA_2706 sprA sprA accC accC metH metH SGRA_2611 SGRA_2611 SGRA_2576 SGRA_2576 rnhB rnhB rng rng SGRA_2545 SGRA_2545 SGRA_2533 SGRA_2533 pnp pnp pyk pyk rnc rnc mtnC mtnC miaB miaB rfbA rfbA hflX hflX SGRA_2430 SGRA_2430 uvrA-2 uvrA-2 cah cah SGRA_2392 SGRA_2392 hutI hutI SGRA_2383 SGRA_2383 thiL thiL SGRA_2361 SGRA_2361 SGRA_2329 SGRA_2329 SGRA_2325 SGRA_2325 SGRA_2318 SGRA_2318 rpoC rpoC ppa ppa pqqL pqqL pdxA pdxA SGRA_2247 SGRA_2247 tadA tadA SGRA_2212 SGRA_2212 SGRA_2198 SGRA_2198 radC radC gltX gltX SGRA_2189 SGRA_2189 SGRA_2187 SGRA_2187 apbE apbE mutY mutY ybeY ybeY queG queG uvrA uvrA rnhA rnhA ftnA ftnA pheS pheS SGRA_2067 SGRA_2067 SGRA_2047 SGRA_2047 SGRA_2044 SGRA_2044 SGRA_2042 SGRA_2042 SGRA_2036 SGRA_2036 SGRA_2033 SGRA_2033 mtnB mtnB SGRA_2021 SGRA_2021 ptpS ptpS cydA cydA SGRA_1980 SGRA_1980 pfk pfk ruvC ruvC SGRA_1957 SGRA_1957 SGRA_1941 SGRA_1941 trmE trmE icmF icmF SGRA_1884 SGRA_1884 iscU iscU SGRA_1870 SGRA_1870 sucA sucA SGRA_1806 SGRA_1806 ubiD ubiD nadA nadA SGRA_1751 SGRA_1751 dnaG dnaG SGRA_1736 SGRA_1736 sdaA-2 sdaA-2 cysQ cysQ suhB suhB SGRA_1653 SGRA_1653 thiH thiH bioD bioD lpxC lpxC SGRA_1545 SGRA_1545 prsA prsA gcp gcp SGRA_1515 SGRA_1515 SGRA_1514 SGRA_1514 SGRA_1512 SGRA_1512 SGRA_1511 SGRA_1511 coxB coxB ileS ileS lysS lysS thiE-2 thiE-2 thiE thiE thiC thiC speB speB cynT cynT SGRA_1374 SGRA_1374 SGRA_1373 SGRA_1373 SGRA_1349 SGRA_1349 mqnC mqnC ftsH ftsH SGRA_1281 SGRA_1281 SGRA_1252 SGRA_1252 SGRA_1245 SGRA_1245 SGRA_1236 SGRA_1236 SGRA_1211 SGRA_1211 dnaJ dnaJ hppD hppD SGRA_1151 SGRA_1151 metK metK recO recO SGRA_1113 SGRA_1113 astE astE ddl ddl SGRA_1094 SGRA_1094 SGRA_1092 SGRA_1092 phhA phhA SGRA_1090 SGRA_1090 def def queE queE crtR crtR SGRA_1051 SGRA_1051 fbp fbp SGRA_1027 SGRA_1027 SGRA_1024 SGRA_1024 SGRA_1023 SGRA_1023 hemN hemN SGRA_1005 SGRA_1005 speA speA katE katE ppnK ppnK SGRA_0933 SGRA_0933 engB engB cysS cysS mraY mraY murE murE ribBA ribBA topA topA SGRA_0843 SGRA_0843 SGRA_0842 SGRA_0842 coaX coaX lpxH lpxH SGRA_0798 SGRA_0798 nth nth SGRA_0786 SGRA_0786 SGRA_0771 SGRA_0771 priA priA SGRA_0746 SGRA_0746 SGRA_0730 SGRA_0730 SGRA_0716 SGRA_0716 icd icd add add SGRA_0702 SGRA_0702 purA purA pilC pilC prpE prpE rimO rimO obgE obgE SGRA_0599 SGRA_0599 SGRA_0015 SGRA_0015 trkH trkH SGRA_0034 SGRA_0034 SGRA_0042 SGRA_0042 panB panB SGRA_0114 SGRA_0114 SGRA_0122 SGRA_0122 SGRA_0133 SGRA_0133 pyrG pyrG uppS uppS SGRA_0207 SGRA_0207 SGRA_0210 SGRA_0210 kdsC kdsC rlmN rlmN sodA sodA SGRA_0275 SGRA_0275 cas1 cas1 SGRA_0280 SGRA_0280 nfi nfi SGRA_0329 SGRA_0329 mrp mrp SGRA_0369 SGRA_0369 sodA-2 sodA-2 SGRA_0379 SGRA_0379 SGRA_0387 SGRA_0387 SGRA_0509 SGRA_0509 hemH hemH map map pckA pckA SGRA_0555 SGRA_0555 gloA gloA rnz rnz
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
SGRA_4226Metallophosphoesterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. (319 aa)
SGRA_4209Cyclase family protein; COG1878 Predicted metal-dependent hydrolase. (256 aa)
SGRA_4195COG1858 Cytochrome c peroxidase. (330 aa)
SGRA_4151COG4206 Outer membrane cobalamin receptor protein. (676 aa)
hemBCOG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (333 aa)
ptpS-2COG0720 6-pyruvoyl-tetrahydropterin synthase. (138 aa)
manB-2COG1109 Phosphomannomutase. (467 aa)
SGRA_4095Hypothetical protein. (358 aa)
hemFCOG0408 Coproporphyrinogen III oxidase. (308 aa)
thrSthreonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (672 aa)
rocFArginase/agmatinase/formiminoglutamase; COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (326 aa)
SGRA_3989phytanoyl-CoA dioxygenase. (315 aa)
SGRA_3976Hypothetical protein. (461 aa)
SGRA_39334'-phosphopantetheinyl transferase superfamily protein; COG0736 Phosphopantetheinyl transferase (holo-ACP synthase); Belongs to the P-Pant transferase superfamily. (190 aa)
dps-2COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); Belongs to the Dps family. (158 aa)
bioACOG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa)
apaGCo2+/Mg2+ efflux protein ApaG; COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport. (129 aa)
katE-2COG0753 Catalase. (576 aa)
SGRA_3842Nucleotidyl transferase; COG1209 dTDP-glucose pyrophosphorylase. (328 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
SGRA_3832Hypothetical protein. (378 aa)
sfcAMalate dehydrogenase; COG0281 Malic enzyme. (403 aa)
SGRA_3819Peptidase M1 membrane alanine aminopeptidase; COG0308 Aminopeptidase N. (675 aa)
SGRA_3797Periplasmic binding protein; COG4558 ABC-type hemin transport system, periplasmic component. (304 aa)
tdkCOG1435 Thymidine kinase. (184 aa)
SGRA_3772Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (497 aa)
hmgACOG3508 Homogentisate 1,2-dioxygenase. (386 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (330 aa)
mqnERadical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (417 aa)
SGRA_3716Hypothetical protein; COG1678 Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (181 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (405 aa)
SGRA_3668Galanin; COG0556 Helicase subunit of the DNA excision repair complex. (323 aa)
acnAAconitate hydratase; COG1048 Aconitase A. (759 aa)
lemALemA family protein; COG0457 FOG: TPR repeat. (328 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (378 aa)
SGRA_3624Carboxypeptidase Taq; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. (499 aa)
SGRA_3613Hypothetical protein. (481 aa)
gshBCOG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (322 aa)
SGRA_3611Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. (319 aa)
SGRA_3562Hypothetical protein. (790 aa)
smsDNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (464 aa)
rpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
SGRA_3458COG1741 Pirin-related protein; Belongs to the pirin family. (287 aa)
acsAcetyl-coenzyme a synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (633 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa)
SGRA_33965 nucleotidase deoxy cytosolic type C; COG4502 Uncharacterized protein conserved in bacteria. (149 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (695 aa)
pepFOligoendopeptidase, M3 family protein; COG1164 Oligoendopeptidase F. (562 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (710 aa)
folECOG0302 GTP cyclohydrolase I. (231 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
clpXSigma 54 interacting domain protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (419 aa)
SGRA_3271Hypothetical protein. (92 aa)
manBCOG1109 Phosphomannomutase. (463 aa)
surE5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
SGRA_3188COG1858 Cytochrome c peroxidase. (459 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (724 aa)
SGRA_3155COG1864 DNA/RNA endonuclease G, NUC1. (269 aa)
SGRA_3148Peptidase M42 family protein; COG1363 Cellulase M and related proteins. (360 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (202 aa)
SGRA_3143Copper-translocating P-type ATPase; COG2217 Cation transport ATPase. (71 aa)
SGRA_3139Zinc finger swim domain-containing protein. (446 aa)
apbE-2Apbe family lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. (338 aa)
SGRA_3095Riboflavin biosynthesis protein ribd; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (348 aa)
rfbA-2Nucleotidyl transferase; COG1209 dTDP-glucose pyrophosphorylase. (331 aa)
dpsCOG0783 DNA-binding ferritin-like protein (oxidative damage protectant); Belongs to the Dps family. (167 aa)
nqrFNa(+)-translocating NADH-quinone reductase subunit F; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. (442 aa)
mtnDMethionine salvage pathway protein E-2/E-2'; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (175 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
SGRA_3030Peptidase M50; COG0750 Predicted membrane-associated Zn-dependent proteases 1. (446 aa)
SGRA_3005Hypothetical protein. (176 aa)
SGRA_3004Radical SAM domain protein; COG0535 Predicted Fe-S oxidoreductases. (344 aa)
SGRA_2999COG1999 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems. (211 aa)
SGRA_2998COG2010 Cytochrome c, mono- and diheme variants. (131 aa)
SGRA_2997Galanin. (331 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (296 aa)
SGRA_2977Peptidase m48 ste24p; COG0501 Zn-dependent protease with chaperone function. (264 aa)
SGRA_2890COG2309 Leucyl aminopeptidase (aminopeptidase T). (365 aa)
troRIron dependent repressor; COG1321 Mn-dependent transcriptional regulator. (223 aa)
vanXPeptidase m15d vanx d-ala-d-ala dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (258 aa)
SGRA_2861COG0621 2-methylthioadenine synthetase. (448 aa)
SGRA_2850Hypothetical protein. (1172 aa)
pepTPeptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (409 aa)
SGRA_2826Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (297 aa)
SGRA_2812Biotin/lipoyl attachment domain-containing protein; COG0511 Biotin carboxyl carrier protein. (160 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (161 aa)
pepNPeptidase M1 membrane alanine aminopeptidase; COG0308 Aminopeptidase N. (874 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (875 aa)
pheTphenylalanyl-tRNA synthetase subunit beta; COG0073 EMAP domain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (831 aa)
copAHeavy metal translocating p-type atpase; COG2217 Cation transport ATPase. (739 aa)
icd-2COG0538 Isocitrate dehydrogenases. (399 aa)
SGRA_2767Peptidase m1 membrane alanine aminopeptidase; COG0308 Aminopeptidase N. (630 aa)
SGRA_2764Hypothetical protein. (373 aa)
SGRA_2736Hypothetical protein; COG0730 Predicted permeases. (247 aa)
rsgAGTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (312 aa)
pcrBGeranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). (236 aa)
SGRA_2707Hypothetical protein. (259 aa)
SGRA_2706COG1858 Cytochrome c peroxidase. (400 aa)
sprAGliding motility protein SprA. (2512 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1225 aa)
SGRA_2611COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. (538 aa)
SGRA_2576COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (361 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (205 aa)
rngCOG1530 Ribonucleases G and E. (520 aa)
SGRA_2545Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
SGRA_2533COG0308 Aminopeptidase N. (548 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (747 aa)
pykCOG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (477 aa)
rncRibonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (252 aa)
mtnC2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (226 aa)
miaB(dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (483 aa)
rfbAGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (289 aa)
hflXGTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (403 aa)
SGRA_2430Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. (956 aa)
uvrA-2UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (930 aa)
cahCOG3338 Carbonic anhydrase. (281 aa)
SGRA_2392COG3000 Sterol desaturase. (401 aa)
hutICOG1228 Imidazolonepropionase and related amidohydrolases. (418 aa)
SGRA_2383Putative vitamin B12 receptor precursor; COG1629 Outer membrane receptor proteins, mostly Fe transport. (882 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (342 aa)
SGRA_2361Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (216 aa)
SGRA_2329Putative deoxyribonucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (195 aa)
SGRA_2325Hypothetical protein. (205 aa)
SGRA_2318Galanin. (302 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1420 aa)
ppaCOG0221 Inorganic pyrophosphatase. (209 aa)
pqqLPeptidase m16 domain protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. (985 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; COG1995 Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family. (517 aa)
SGRA_2247COG2120 Uncharacterized proteins, LmbE homologs. (237 aa)
tadACmp/dcmp deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (152 aa)
SGRA_2212Hypothetical protein. (195 aa)
SGRA_2198COG0694 Thioredoxin-like proteins and domains. (207 aa)
radCCOG2003 DNA repair proteins; Belongs to the UPF0758 family. (242 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (510 aa)
SGRA_2189COG1734 DnaK suppressor protein. (138 aa)
SGRA_2187COG0723 Rieske Fe-S protein. (137 aa)
apbEThiamin biosynthesis lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. (327 aa)
mutYA/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (402 aa)
ybeYHypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (145 aa)
queGIron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (309 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa)
rnhAPutative ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase H family. (209 aa)
ftnAFerritin 1; Iron-storage protein. (172 aa)
pheSCOG0016 Phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (345 aa)
SGRA_2067Putative zinc protease; COG0612 Predicted Zn-dependent peptidases. (412 aa)
SGRA_2047Hypothetical protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. (365 aa)
SGRA_2044Arginase. (349 aa)
SGRA_2042Peptidase m48 ste24p; COG4783 Putative Zn-dependent protease, contains TPR repeats. (265 aa)
SGRA_2036Cytochrome oxidase assembly; COG1612 Uncharacterized protein required for cytochrome oxidase assembly. (383 aa)
SGRA_2033Putative Zn-dependent aminopeptidase; COG0308 Aminopeptidase N. (753 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (224 aa)
SGRA_2021Mov34/MPN/PAD-1 family protein; COG1310 Predicted metal-dependent protease of the PAD1/JAB1 superfamily. (155 aa)
ptpSCOG0720 6-pyruvoyl-tetrahydropterin synthase. (138 aa)
cydACOG1271 Cytochrome bd-type quinol oxidase, subunit 1. (459 aa)
SGRA_1980Putative Zn-dependent aminopeptidase; COG0308 Aminopeptidase N. (1009 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (177 aa)
SGRA_1957FeoA family protein. (120 aa)
SGRA_1941Phosphodiesterase, MJ0936 family protein; COG0622 Predicted phosphoesterase. (173 aa)
trmEtRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (455 aa)
icmFmethylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1119 aa)
SGRA_1884Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (108 aa)
iscUFeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
SGRA_1870Hypothetical protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. (138 aa)
sucACOG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (922 aa)
SGRA_1806COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (713 aa)
ubiDUbiD family decarboxylase; COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Belongs to the UbiD family. (610 aa)
nadAQuinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (335 aa)
SGRA_1751Hypothetical protein. (256 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (683 aa)
SGRA_1736Peptidase M16 domain protein; COG0612 Predicted Zn-dependent peptidases. (425 aa)
sdaA-2COG1760 L-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (482 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (263 aa)
suhBInositol monophosphatase; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (268 aa)
SGRA_1653Membrane associated hydrolase. (851 aa)
thiHCOG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (381 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (213 aa)
lpxC3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa)
SGRA_1545Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (281 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (320 aa)
gcpUGMP family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (396 aa)
SGRA_1515COG2857 Cytochrome c1. (486 aa)
SGRA_1514Putative iron-sulfur binding oxidoreductase; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing. (1121 aa)
SGRA_1512Hypothetical protein. (177 aa)
SGRA_1511COG2010 Cytochrome c, mono- and diheme variants. (252 aa)
coxBCytochrome c oxidase subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (462 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1123 aa)
lysSCOG1190 Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (545 aa)
thiE-2Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (218 aa)
thiEThiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (218 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa)
speBArginase/agmatinase/formiminoglutamase; COG0010 Arginase/agmatinase/formimionoglutamate hydrolase, arginase family; Belongs to the arginase family. (342 aa)
cynTCarbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (196 aa)
SGRA_1374Hypothetical protein. (137 aa)
SGRA_1373COG1981 Predicted membrane protein. (188 aa)
SGRA_1349Hypothetical protein; COG0247 Fe-S oxidoreductase. (455 aa)
mqnCRadical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (380 aa)
ftsHATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (675 aa)
SGRA_1281Hypothetical protein. (611 aa)
SGRA_1252Glycosyl transferase group 1; COG0535 Predicted Fe-S oxidoreductases. (341 aa)
SGRA_1245Alcohol dehydrogenase zinc-binding domain protein; COG1064 Zn-dependent alcohol dehydrogenases. (350 aa)
SGRA_1236COG2120 Uncharacterized proteins, LmbE homologs. (238 aa)
SGRA_1211Peptidase M1 membrane alanine aminopeptidase; COG0308 Aminopeptidase N. (668 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (392 aa)
hppDCOG3185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins. (364 aa)
SGRA_1151Nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (399 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (417 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (238 aa)
SGRA_1113FeS assembly protein IscX; COG2975 Uncharacterized protein conserved in bacteria. (79 aa)
astESuccinylglutamate desuccinylase/aspartoacylase family protein; COG2988 Succinylglutamate desuccinylase. (333 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (902 aa)
SGRA_1094Hypothetical protein; COG0247 Fe-S oxidoreductase. (268 aa)
SGRA_1092Hypothetical protein. (334 aa)
phhACOG3186 Phenylalanine-4-hydroxylase. (245 aa)
SGRA_1090Radical SAM domain-containing protein; COG0641 Arylsulfatase regulator (Fe-S oxidoreductase). (404 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (185 aa)
queERadical SAM family protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (255 aa)
crtRBeta-carotene hydroxylase. (154 aa)
SGRA_10514Fe-4S ferredoxin, iron-sulfur binding protein; COG1145 Ferredoxin. (118 aa)
fbpCOG0158 Fructose-1,6-bisphosphatase. (327 aa)
SGRA_1027COG1864 DNA/RNA endonuclease G, NUC1. (410 aa)
SGRA_1024Zinc finger SWIM domain protein. (534 aa)
SGRA_1023RNA-directed DNA polymerase; COG3344 Retron-type reverse transcriptase. (554 aa)
hemNOxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (349 aa)
SGRA_1005Aminopeptidase; COG1363 Cellulase M and related proteins. (354 aa)
speAOrn/DAP/Arg decarboxylase 2; COG1166 Arginine decarboxylase (spermidine biosynthesis). (465 aa)
katECOG0753 Catalase; Belongs to the catalase family. (504 aa)
ppnKInorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa)
SGRA_0933Phosphopantetheinyl transferase-like protein; COG2091 Phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (210 aa)
engBGTP-binding protein HSR1-related protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (202 aa)
cysSCOG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (556 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (417 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (491 aa)
ribBAGtp cyclohydrolase ii; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (415 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (876 aa)
SGRA_0843Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (1008 aa)
SGRA_0842Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (430 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (247 aa)
lpxHMetallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (265 aa)
SGRA_0798COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ). (286 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
SGRA_0786Hypothetical protein; COG4570 Holliday junction resolvase. (186 aa)
SGRA_0771Hypothetical protein. (617 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (839 aa)
SGRA_0746Putative zinc-type alcohol dehydrogenase-like protein; COG1064 Zn-dependent alcohol dehydrogenases. (335 aa)
SGRA_0730Hypothetical protein. (169 aa)
SGRA_0716COG1858 Cytochrome c peroxidase. (327 aa)
icdCOG0473 Isocitrate/isopropylmalate dehydrogenase. (481 aa)
addCOG1816 Adenosine deaminase. (431 aa)
SGRA_070223S rRNA (uracil-5-)-methyltransferase RumA; COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (501 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (422 aa)
pilCCOG1459 Type II secretory pathway, component PulF. (375 aa)
prpEprpE protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (627 aa)
rimOSSU ribosomal protein s12p methylthiotransferase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (441 aa)
obgEGTPase CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (335 aa)
SGRA_0599COG0694 Thioredoxin-like proteins and domains. (82 aa)
SGRA_0015Calcium-binding EF-hand-containing protein; COG5126 Ca2+-binding protein (EF-Hand superfamily). (150 aa)
trkHTrk system potassium uptake protein; COG0168 Trk-type K+ transport systems, membrane components. (500 aa)
SGRA_0034Putative metallopeptidase, M16 family protein. (336 aa)
SGRA_0042Hypothetical protein. (479 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa)
SGRA_0114COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes. (348 aa)
SGRA_0122COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (435 aa)
SGRA_0133Cytochrome c family protein. (203 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
uppSUndecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa)
SGRA_0207Tetratricopeptide repeat domain protein; COG0457 FOG: TPR repeat. (285 aa)
SGRA_0210Tetratricopeptide TPR_2; COG0457 FOG: TPR repeat. (282 aa)
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; COG1778 Low specificity phosphatase (HAD superfamily). (174 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (348 aa)
sodAManganese/iron superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (256 aa)
SGRA_0275COG1343 Uncharacterized protein predicted to be involved in DNA repair. (98 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (321 aa)
SGRA_0280COG2010 Cytochrome c, mono- and diheme variants. (121 aa)
nfiEndonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (229 aa)
SGRA_03292OG-Fe(II) oxygenase; COG3751 Predicted proline hydroxylase. (195 aa)
mrpATP-binding protein, Mrp/Nbp35 family; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (364 aa)
SGRA_0369Lvivd repeat-containing protein. (430 aa)
sodA-2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (203 aa)
SGRA_0379Hypothetical protein. (150 aa)
SGRA_0387Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (119 aa)
SGRA_05092OG-Fe(II) oxygenase; COG3491 Isopenicillin N synthase and related dioxygenases; Belongs to the iron/ascorbate-dependent oxidoreductase family. (318 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (340 aa)
mapMethionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (267 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
SGRA_0555Hypothetical protein; COG0730 Predicted permeases. (252 aa)
gloAmethylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. (133 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (304 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
Server load: low (14%) [HD]