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nadD nadD phrB-2 phrB-2 SGRA_3396 SGRA_3396 SGRA_3259 SGRA_3259 kptA kptA SGRA_3156 SGRA_3156 SGRA_3138 SGRA_3138 mtnD mtnD miaA miaA mutS2 mutS2 mtnC mtnC SGRA_2453 SGRA_2453 dcm dcm SGRA_2416 SGRA_2416 hemA hemA phhB phhB SGRA_2068 SGRA_2068 paiB paiB ptpS ptpS SGRA_1936 SGRA_1936 clpS clpS SGRA_1463 SGRA_1463 SGRA_1355 SGRA_1355 pdhA pdhA phrB phrB SGRA_1217 SGRA_1217 crtR crtR ubiX ubiX SGRA_0925 SGRA_0925 SGRA_0564 SGRA_0564 SGRA_0469 SGRA_0469 SGRA_0329 SGRA_0329 SGRA_0034 SGRA_0034 ptpS-2 ptpS-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (191 aa)
phrB-2COG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (445 aa)
SGRA_33965 nucleotidase deoxy cytosolic type C; COG4502 Uncharacterized protein conserved in bacteria. (149 aa)
SGRA_3259Lipid-binding START domain-containing protein. (196 aa)
kptAPhosphate acetyltransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (186 aa)
SGRA_3156Hypothetical protein. (473 aa)
SGRA_3138Hypothetical protein. (509 aa)
mtnDMethionine salvage pathway protein E-2/E-2'; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (175 aa)
miaAtRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (302 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa)
mtnC2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (226 aa)
SGRA_2453COG2940 Proteins containing SET domain. (128 aa)
dcmDNA-cytosine methyltransferase; COG0270 Site-specific DNA methylase. (418 aa)
SGRA_2416Transcriptional regulator, XRE family; COG1813 Predicted transcription factor, homolog of eukaryotic MBF1. (105 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (466 aa)
phhBTranscriptional coactivator/pterin dehydratase; COG2154 Pterin-4a-carbinolamine dehydratase. (87 aa)
SGRA_2068Metal dependent phosphohydrolase; COG1078 HD superfamily phosphohydrolases. (406 aa)
paiBCOG2808 Transcriptional regulator. (275 aa)
ptpSCOG0720 6-pyruvoyl-tetrahydropterin synthase. (138 aa)
SGRA_19363-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (665 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. (101 aa)
SGRA_1463COG0526 Thiol-disulfide isomerase and thioredoxins. (78 aa)
SGRA_1355Smr protein/MutS2; COG1193 Mismatch repair ATPase (MutS family). (365 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (335 aa)
phrBCOG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (466 aa)
SGRA_1217Hypothetical protein. (288 aa)
crtRBeta-carotene hydroxylase. (154 aa)
ubiX3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (191 aa)
SGRA_0925Polysaccharide biosynthesis protein; COG0417 DNA polymerase elongation subunit (family B). (140 aa)
SGRA_0564Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. (315 aa)
SGRA_0469Hypothetical protein. (541 aa)
SGRA_03292OG-Fe(II) oxygenase; COG3751 Predicted proline hydroxylase. (195 aa)
SGRA_0034Putative metallopeptidase, M16 family protein. (336 aa)
ptpS-2COG0720 6-pyruvoyl-tetrahydropterin synthase. (138 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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