STRINGSTRING
SGRA_0085 SGRA_0085 glpK glpK SGRA_0043 SGRA_0043 SGRA_0031 SGRA_0031 SGRA_4226 SGRA_4226 SGRA_4225 SGRA_4225 SGRA_4209 SGRA_4209 ggt-2 ggt-2 SGRA_4026 SGRA_4026 SGRA_3989 SGRA_3989 SGRA_3965 SGRA_3965 SGRA_3885 SGRA_3885 katE-2 katE-2 dut dut mazG mazG xseA xseA hmgA hmgA SGRA_3736 SGRA_3736 SGRA_3648 SGRA_3648 amn amn SGRA_3525 SGRA_3525 SGRA_3474 SGRA_3474 SGRA_3396 SGRA_3396 anmK anmK pncA pncA SGRA_3198 SGRA_3198 surE surE gcvP gcvP SGRA_3134 SGRA_3134 SGRA_3129 SGRA_3129 acm acm SGRA_3051 SGRA_3051 gcvH gcvH SGRA_2947 SGRA_2947 pepT pepT SGRA_2826 SGRA_2826 cdd cdd rny rny sucB sucB SGRA_2632 SGRA_2632 rnhB rnhB SGRA_2545 SGRA_2545 pnp pnp fadJ fadJ fadA fadA SGRA_2475 SGRA_2475 SGRA_2469 SGRA_2469 hutI hutI SGRA_2361 SGRA_2361 SGRA_2329 SGRA_2329 SGRA_2325 SGRA_2325 SGRA_2261 SGRA_2261 SGRA_2068 SGRA_2068 mltD mltD SGRA_2010 SGRA_2010 SGRA_1965 SGRA_1965 ald ald SGRA_1937 SGRA_1937 SGRA_1893 SGRA_1893 dtd dtd deoC deoC hutU hutU SGRA_1664 SGRA_1664 ggt ggt SGRA_1444 SGRA_1444 ampC-2 ampC-2 pcaF pcaF hutH hutH SGRA_1250 SGRA_1250 mtnN mtnN SGRA_1189 SGRA_1189 crt crt astE astE speA speA SGRA_0982 SGRA_0982 katE katE SGRA_0951 SGRA_0951 SGRA_0949 SGRA_0949 SGRA_0936 SGRA_0936 gabD gabD SGRA_0843 SGRA_0843 SGRA_0842 SGRA_0842 atoB-2 atoB-2 SGRA_0759 SGRA_0759 SGRA_0693 SGRA_0693 kynU kynU SGRA_0340 SGRA_0340 gcvT gcvT atoB atoB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SGRA_0085Lipoprotein. (602 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (494 aa)
SGRA_0043Type 4 fimbriae expression regulatory protein pilR; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (549 aa)
SGRA_0031COG3643 Glutamate formiminotransferase. (561 aa)
SGRA_4226Metallophosphoesterase; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. (319 aa)
SGRA_42255'-Nucleotidase domain protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases. (252 aa)
SGRA_4209Cyclase family protein; COG1878 Predicted metal-dependent hydrolase. (256 aa)
ggt-2Gamma-glutamyltranspeptidase small chain; COG0405 Gamma-glutamyltransferase. (491 aa)
SGRA_4026Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (262 aa)
SGRA_3989phytanoyl-CoA dioxygenase. (315 aa)
SGRA_3965COG4539 Predicted membrane protein. (160 aa)
SGRA_3885Hypothetical protein; COG1561 Uncharacterized stress-induced protein. (287 aa)
katE-2COG0753 Catalase. (576 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
mazGNucleoside triphosphate pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. (254 aa)
xseACOG1570 Exonuclease VII, large subunit; Belongs to the XseA family. (399 aa)
hmgACOG3508 Homogentisate 1,2-dioxygenase. (386 aa)
SGRA_3736Hypothetical protein; COG0210 Superfamily I DNA and RNA helicases. (1481 aa)
SGRA_3648Hypothetical protein; COG1575 1,4-dihydroxy-2-naphthoate octaprenyltransferase. (271 aa)
amnAMP nucleosidase; COG0775 Nucleoside phosphorylase. (257 aa)
SGRA_3525COG1012 NAD-dependent aldehyde dehydrogenases. (542 aa)
SGRA_3474N-formylkynurenine (aryl-) formamidase. (254 aa)
SGRA_33965 nucleotidase deoxy cytosolic type C; COG4502 Uncharacterized protein conserved in bacteria. (149 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa)
pncANicotinamidase; COG1335 Amidases related to nicotinamidase. (207 aa)
SGRA_3198Hypothetical protein. (306 aa)
surE5'(3')-nucleotidase/polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)
SGRA_3134Hypothetical protein; COG0804 Urea amidohydrolase (urease) alpha subunit. (490 aa)
SGRA_3129COG1231 Monoamine oxidase. (447 aa)
acmGlycoside hydrolase family 25; COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase). (218 aa)
SGRA_3051Fumarylacetoacetase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (424 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
SGRA_2947Extracellular nuclease. (679 aa)
pepTPeptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (409 aa)
SGRA_2826Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (297 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (161 aa)
rnyPhosphodiesterase; Endoribonuclease that initiates mRNA decay. (545 aa)
sucB2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa)
SGRA_2632COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (471 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (205 aa)
SGRA_2545Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (747 aa)
fadJ3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (704 aa)
fadACOG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
SGRA_2475MazG nucleotide pyrophosphohydrolase; COG1694 Predicted pyrophosphatase. (113 aa)
SGRA_2469COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (517 aa)
hutICOG1228 Imidazolonepropionase and related amidohydrolases. (418 aa)
SGRA_2361Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (216 aa)
SGRA_2329Putative deoxyribonucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (195 aa)
SGRA_2325Hypothetical protein. (205 aa)
SGRA_2261COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. (300 aa)
SGRA_2068Metal dependent phosphohydrolase; COG1078 HD superfamily phosphohydrolases. (406 aa)
mltDCOG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). (600 aa)
SGRA_2010Fumarylacetoacetate (FAA) hydrolase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (204 aa)
SGRA_1965Beta-lactamase domain protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Belongs to the UPF0173 family. (232 aa)
aldCOG0686 Alanine dehydrogenase. (407 aa)
SGRA_1937COG0506 Proline dehydrogenase. (362 aa)
SGRA_1893COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (506 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (152 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (672 aa)
SGRA_1664Hypothetical protein; COG3386 Gluconolactonase. (265 aa)
ggtCOG0405 Gamma-glutamyltransferase. (560 aa)
SGRA_1444Hypothetical protein. (98 aa)
ampC-2COG2367 Beta-lactamase class A. (350 aa)
pcaFBeta-ketoadipyl CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
hutHCOG2986 Histidine ammonia-lyase. (500 aa)
SGRA_1250Type 4 fimbriae expression regulatory protein PilR; COG3283 Transcriptional regulator of aromatic amino acids metabolism. (300 aa)
mtnNPurine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (227 aa)
SGRA_1189Amidohydrolase 3; COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold. (564 aa)
crtCOG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
astESuccinylglutamate desuccinylase/aspartoacylase family protein; COG2988 Succinylglutamate desuccinylase. (333 aa)
speAOrn/DAP/Arg decarboxylase 2; COG1166 Arginine decarboxylase (spermidine biosynthesis). (465 aa)
SGRA_0982COG0686 Alanine dehydrogenase. (403 aa)
katECOG0753 Catalase; Belongs to the catalase family. (504 aa)
SGRA_0951Doxx family protein. (564 aa)
SGRA_0949COG1722 Exonuclease VII small subunit. (65 aa)
SGRA_0936COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. (209 aa)
gabDCOG1012 NAD-dependent aldehyde dehydrogenases. (453 aa)
SGRA_0843Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (1008 aa)
SGRA_0842Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (430 aa)
atoB-2COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
SGRA_0759Dipeptidyl-peptidase 7; Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. (711 aa)
SGRA_0693Hypothetical protein. (126 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa)
SGRA_0340Esterase/lipase, putative; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (214 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
atoBacetoacetyl-CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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