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| | lpxA | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (261 aa) |
| | SGRA_1545 | Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (281 aa) |
| | SGRA_1477 | Dolichyl-phosphate-mannose-protein mannosyltransferase family protein; COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family. (544 aa) |
| | pcaF | Beta-ketoadipyl CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | fabI | Short-chain dehydrogenase/reductase SDR; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (261 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl-carrier- protein]dehydratase; COG0764 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases. (153 aa) |
| | SGRA_1401 | Beta-ketoacyl synthase; COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (427 aa) |
| | SGRA_1358 | Hypothetical protein. (310 aa) |
| | SGRA_1264 | Hypothetical protein. (491 aa) |
| | mvaD | COG3407 Mevalonate pyrophosphate decarboxylase. (347 aa) |
| | crt | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa) |
| | SGRA_1151 | Nucleotidyl transferase; COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon). (399 aa) |
| | SGRA_1085 | Transmembrane prediction. (237 aa) |
| | SGRA_1067 | COG1233 Phytoene dehydrogenase and related proteins. (494 aa) |
| | SGRA_1013 | Acyltransferase family protein; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (200 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (361 aa) |
| | lpxH | Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (265 aa) |
| | atoB-2 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | SGRA_0713 | Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (172 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (373 aa) |
| | SGRA_0690 | Alcohol dehydrogenase zinc-binding domain protein; COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases. (336 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa) |
| | SGRA_0615 | Putative acyltransferase; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (269 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (361 aa) |
| | SGRA_0491 | Hypothetical protein. (246 aa) |
| | plsB | COG2937 Glycerol-3-phosphate O-acyltransferase. (579 aa) |
| | fabD | COG0331 (acyl-carrier-protein) S-malonyltransferase. (293 aa) |
| | SGRA_0323 | Hypothetical protein. (479 aa) |
| | kdsC | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; COG1778 Low specificity phosphatase (HAD superfamily). (174 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (259 aa) |
| | atoB | acetoacetyl-CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | SGRA_0090 | COG0110 Acetyltransferase (isoleucine patch superfamily). (189 aa) |
| | SGRA_0075 | COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (395 aa) |
| | SGRA_4190 | COG1607 Acyl-CoA hydrolase. (163 aa) |
| | SGRA_4150 | Phosphoesterase PA-phosphatase related protein; COG0671 Membrane-associated phospholipid phosphatase. (190 aa) |
| | lpxD-2 | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (351 aa) |
| | kdtA | 3-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (414 aa) |
| | SGRA_3965 | COG4539 Predicted membrane protein. (160 aa) |
| | SGRA_3933 | 4'-phosphopantetheinyl transferase superfamily protein; COG0736 Phosphopantetheinyl transferase (holo-ACP synthase); Belongs to the P-Pant transferase superfamily. (190 aa) |
| | SGRA_3932 | Acyl carrier protein. (81 aa) |
| | plsC | COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (247 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (238 aa) |
| | SGRA_3772 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (497 aa) |
| | ispB | Polyprenyl synthetase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (326 aa) |
| | gpsA | COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (348 aa) |
| | SGRA_3482 | RfaQ-like lipopolysaccharide core biosynthesis glycosyl transferase; COG0859 ADP-heptose:LPS heptosyltransferase. (346 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | SGRA_3352 | Amine oxidase; COG1233 Phytoene dehydrogenase and related proteins. (480 aa) |
| | SGRA_3198 | Hypothetical protein. (306 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (293 aa) |
| | htrB | COG1560 Lauroyl/myristoyl acyltransferase. (295 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (296 aa) |
| | fabH-2 | COG0332 3-oxoacyl-[acyl-carrier-protein] synthase III. (358 aa) |
| | SGRA_2915 | COG1233 Phytoene dehydrogenase and related proteins. (490 aa) |
| | SGRA_2914 | Squalene/phytoene synthase; COG1562 Phytoene/squalene synthetase. (280 aa) |
| | SGRA_2903 | Glycosyl transferase family protein. (556 aa) |
| | paaH | COG1250 3-hydroxyacyl-CoA dehydrogenase. (296 aa) |
| | SGRA_2812 | Biotin/lipoyl attachment domain-containing protein; COG0511 Biotin carboxyl carrier protein. (160 aa) |
| | mvaK1 | COG1577 Mevalonate kinase. (296 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (352 aa) |
| | SGRA_2730 | Lipopolysaccharide biosynthesis protein. (372 aa) |
| | pcrB | Geranylgeranylglyceryl phosphate synthase-like protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). (236 aa) |
| | SGRA_2636 | Hypothetical protein. (288 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (171 aa) |
| | fadJ | 3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (704 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | fabF | 3-oxoacyl-(acyl-carrier-protein) synthase ii; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (416 aa) |
| | fadA | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa) |
| | SGRA_2458 | COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. (428 aa) |
| | SGRA_2349 | Phospholipase D/Transphosphatidylase; COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes. (543 aa) |
| | pssA | CDP-diacylglycerol-serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; Belongs to the KdsA family. (267 aa) |
| | SGRA_2283 | Transferase hexapeptide repeat protein; COG0110 Acetyltransferase (isoleucine patch superfamily). (214 aa) |
| | SGRA_2267 | COG2035 Predicted membrane protein. (302 aa) |
| | SGRA_2127 | Heptosyltransferase family protein; COG0859 ADP-heptose:LPS heptosyltransferase. (332 aa) |
| | fabI-2 | COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH). (294 aa) |
| | SGRA_2095 | Hypothetical protein. (550 aa) |
| | SGRA_2083 | Polyprenyl synthetase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (328 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. (286 aa) |
| | lpxD | COG1044 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase. (325 aa) |
| | SGRA_1859 | Thioesterase superfamily protein; COG1607 Acyl-CoA hydrolase. (128 aa) |
| | SGRA_1804 | COG0818 Diacylglycerol kinase. (125 aa) |
| | SGRA_1802 | Metallophosphoesterase; COG1408 Predicted phosphohydrolases. (416 aa) |
| | fadD | COG1022 Long-chain acyl-CoA synthetases (AMP-forming). (607 aa) |
| | lpxC | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (461 aa) |
