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SGRA_4209 SGRA_4209 SGRA_2469 SGRA_2469 fadA fadA fadJ fadJ SGRA_2545 SGRA_2545 SGRA_2632 SGRA_2632 sucB sucB cdd cdd SGRA_2826 SGRA_2826 gcvH gcvH SGRA_3051 SGRA_3051 SGRA_3129 SGRA_3129 gcvP gcvP SGRA_3198 SGRA_3198 gpm gpm anmK anmK SGRA_3474 SGRA_3474 rpe rpe SGRA_3525 SGRA_3525 amn amn hmgA hmgA SGRA_3989 SGRA_3989 SGRA_4026 SGRA_4026 SGRA_0031 SGRA_0031 glpK glpK atoB atoB gcvT gcvT kynU kynU SGRA_0693 SGRA_0693 atoB-2 atoB-2 SGRA_0842 SGRA_0842 SGRA_0843 SGRA_0843 gabD gabD SGRA_0982 SGRA_0982 speA speA astE astE crt crt SGRA_1189 SGRA_1189 mtnN mtnN hutH hutH pcaF pcaF suhB suhB hutU hutU cysQ cysQ dtd dtd SGRA_1893 SGRA_1893 SGRA_1937 SGRA_1937 ald ald SGRA_1965 SGRA_1965 SGRA_2010 SGRA_2010 SGRA_2361 SGRA_2361 hutI hutI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SGRA_4209Cyclase family protein; COG1878 Predicted metal-dependent hydrolase. (256 aa)
SGRA_2469COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (517 aa)
fadACOG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
fadJ3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase. (704 aa)
SGRA_2545Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (413 aa)
SGRA_2632COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (471 aa)
sucB2-oxoglutarate dehydrogenase, e2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (420 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (161 aa)
SGRA_2826Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (297 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
SGRA_3051Fumarylacetoacetase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (424 aa)
SGRA_3129COG1231 Monoamine oxidase. (447 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)
SGRA_3198Hypothetical protein. (306 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa)
SGRA_3474N-formylkynurenine (aryl-) formamidase. (254 aa)
rpeCOG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa)
SGRA_3525COG1012 NAD-dependent aldehyde dehydrogenases. (542 aa)
amnAMP nucleosidase; COG0775 Nucleoside phosphorylase. (257 aa)
hmgACOG3508 Homogentisate 1,2-dioxygenase. (386 aa)
SGRA_3989phytanoyl-CoA dioxygenase. (315 aa)
SGRA_4026Hypothetical protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold. (262 aa)
SGRA_0031COG3643 Glutamate formiminotransferase. (561 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (494 aa)
atoBacetoacetyl-CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa)
SGRA_0693Hypothetical protein. (126 aa)
atoB-2COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
SGRA_0842Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (430 aa)
SGRA_0843Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (1008 aa)
gabDCOG1012 NAD-dependent aldehyde dehydrogenases. (453 aa)
SGRA_0982COG0686 Alanine dehydrogenase. (403 aa)
speAOrn/DAP/Arg decarboxylase 2; COG1166 Arginine decarboxylase (spermidine biosynthesis). (465 aa)
astESuccinylglutamate desuccinylase/aspartoacylase family protein; COG2988 Succinylglutamate desuccinylase. (333 aa)
crtCOG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
SGRA_1189Amidohydrolase 3; COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold. (564 aa)
mtnNPurine or other phosphorylase family 1; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (227 aa)
hutHCOG2986 Histidine ammonia-lyase. (500 aa)
pcaFBeta-ketoadipyl CoA thiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
suhBInositol monophosphatase; COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family. (268 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (672 aa)
cysQ3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (263 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (152 aa)
SGRA_1893COG1012 NAD-dependent aldehyde dehydrogenases; Belongs to the aldehyde dehydrogenase family. (506 aa)
SGRA_1937COG0506 Proline dehydrogenase. (362 aa)
aldCOG0686 Alanine dehydrogenase. (407 aa)
SGRA_1965Beta-lactamase domain protein; COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Belongs to the UPF0173 family. (232 aa)
SGRA_2010Fumarylacetoacetate (FAA) hydrolase; COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (204 aa)
SGRA_2361Beta-lactamase domain protein; COG0491 Zn-dependent hydrolases, including glyoxylases. (216 aa)
hutICOG1228 Imidazolonepropionase and related amidohydrolases. (418 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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