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tadA tadA SGRA_2247 SGRA_2247 rpoC rpoC hutI hutI SGRA_2392 SGRA_2392 cah cah SGRA_2533 SGRA_2533 rnhB rnhB metH metH SGRA_2767 SGRA_2767 alaS alaS pepN pepN cdd cdd pepT pepT vanX vanX troR troR mtnD mtnD dps dps SGRA_3095 SGRA_3095 SGRA_3139 SGRA_3139 clpX clpX gpm gpm folE folE mqnE mqnE bioB bioB hmgA hmgA tdk tdk SGRA_3819 SGRA_3819 bioA bioA dps-2 dps-2 SGRA_3989 SGRA_3989 SGRA_4209 SGRA_4209 SGRA_0133 SGRA_0133 SGRA_0329 SGRA_0329 SGRA_0387 SGRA_0387 map map rnz rnz SGRA_0599 SGRA_0599 add add SGRA_0746 SGRA_0746 priA priA SGRA_0842 SGRA_0842 SGRA_0843 SGRA_0843 ribBA ribBA cysS cysS SGRA_1024 SGRA_1024 SGRA_1051 SGRA_1051 crtR crtR phhA phhA astE astE SGRA_1113 SGRA_1113 dnaJ dnaJ SGRA_1211 SGRA_1211 SGRA_1236 SGRA_1236 SGRA_1245 SGRA_1245 ftsH ftsH mqnC mqnC cynT cynT thiC thiC ileS ileS coxB coxB gcp gcp SGRA_1545 SGRA_1545 thiH thiH dnaG dnaG iscU iscU SGRA_1884 SGRA_1884 SGRA_1957 SGRA_1957 SGRA_1980 SGRA_1980 SGRA_2033 SGRA_2033 ftnA ftnA ybeY ybeY SGRA_2189 SGRA_2189 gltX gltX SGRA_2198 SGRA_2198
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tadACmp/dcmp deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (152 aa)
SGRA_2247COG2120 Uncharacterized proteins, LmbE homologs. (237 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1420 aa)
hutICOG1228 Imidazolonepropionase and related amidohydrolases. (418 aa)
SGRA_2392COG3000 Sterol desaturase. (401 aa)
cahCOG3338 Carbonic anhydrase. (281 aa)
SGRA_2533COG0308 Aminopeptidase N. (548 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (205 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1225 aa)
SGRA_2767Peptidase m1 membrane alanine aminopeptidase; COG0308 Aminopeptidase N. (630 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (875 aa)
pepNPeptidase M1 membrane alanine aminopeptidase; COG0308 Aminopeptidase N. (874 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (161 aa)
pepTPeptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (409 aa)
vanXPeptidase m15d vanx d-ala-d-ala dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (258 aa)
troRIron dependent repressor; COG1321 Mn-dependent transcriptional regulator. (223 aa)
mtnDMethionine salvage pathway protein E-2/E-2'; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (175 aa)
dpsCOG0783 DNA-binding ferritin-like protein (oxidative damage protectant); Belongs to the Dps family. (167 aa)
SGRA_3095Riboflavin biosynthesis protein ribd; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (348 aa)
SGRA_3139Zinc finger swim domain-containing protein. (446 aa)
clpXSigma 54 interacting domain protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (419 aa)
gpmPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
folECOG0302 GTP cyclohydrolase I. (231 aa)
mqnERadical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (417 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (330 aa)
hmgACOG3508 Homogentisate 1,2-dioxygenase. (386 aa)
tdkCOG1435 Thymidine kinase. (184 aa)
SGRA_3819Peptidase M1 membrane alanine aminopeptidase; COG0308 Aminopeptidase N. (675 aa)
bioACOG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (432 aa)
dps-2COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); Belongs to the Dps family. (158 aa)
SGRA_3989phytanoyl-CoA dioxygenase. (315 aa)
SGRA_4209Cyclase family protein; COG1878 Predicted metal-dependent hydrolase. (256 aa)
SGRA_0133Cytochrome c family protein. (203 aa)
SGRA_03292OG-Fe(II) oxygenase; COG3751 Predicted proline hydroxylase. (195 aa)
SGRA_0387Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (119 aa)
mapMethionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (267 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (304 aa)
SGRA_0599COG0694 Thioredoxin-like proteins and domains. (82 aa)
addCOG1816 Adenosine deaminase. (431 aa)
SGRA_0746Putative zinc-type alcohol dehydrogenase-like protein; COG1064 Zn-dependent alcohol dehydrogenases. (335 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (839 aa)
SGRA_0842Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (430 aa)
SGRA_0843Amidohydrolase; COG1228 Imidazolonepropionase and related amidohydrolases. (1008 aa)
ribBAGtp cyclohydrolase ii; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (415 aa)
cysSCOG0215 Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (556 aa)
SGRA_1024Zinc finger SWIM domain protein. (534 aa)
SGRA_10514Fe-4S ferredoxin, iron-sulfur binding protein; COG1145 Ferredoxin. (118 aa)
crtRBeta-carotene hydroxylase. (154 aa)
phhACOG3186 Phenylalanine-4-hydroxylase. (245 aa)
astESuccinylglutamate desuccinylase/aspartoacylase family protein; COG2988 Succinylglutamate desuccinylase. (333 aa)
SGRA_1113FeS assembly protein IscX; COG2975 Uncharacterized protein conserved in bacteria. (79 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (392 aa)
SGRA_1211Peptidase M1 membrane alanine aminopeptidase; COG0308 Aminopeptidase N. (668 aa)
SGRA_1236COG2120 Uncharacterized proteins, LmbE homologs. (238 aa)
SGRA_1245Alcohol dehydrogenase zinc-binding domain protein; COG1064 Zn-dependent alcohol dehydrogenases. (350 aa)
ftsHATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (675 aa)
mqnCRadical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (380 aa)
cynTCarbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (196 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (623 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1123 aa)
coxBCytochrome c oxidase subunit II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (462 aa)
gcpUGMP family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (396 aa)
SGRA_1545Metallophosphoesterase; COG2908 Uncharacterized protein conserved in bacteria. (281 aa)
thiHCOG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (381 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (683 aa)
iscUFeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
SGRA_1884Iron-sulfur cluster assembly accessory protein; Belongs to the HesB/IscA family. (108 aa)
SGRA_1957FeoA family protein. (120 aa)
SGRA_1980Putative Zn-dependent aminopeptidase; COG0308 Aminopeptidase N. (1009 aa)
SGRA_2033Putative Zn-dependent aminopeptidase; COG0308 Aminopeptidase N. (753 aa)
ftnAFerritin 1; Iron-storage protein. (172 aa)
ybeYHypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (145 aa)
SGRA_2189COG1734 DnaK suppressor protein. (138 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (510 aa)
SGRA_2198COG0694 Thioredoxin-like proteins and domains. (207 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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