STRINGSTRING
ahpC-3 ahpC-3 rpoE-11 rpoE-11 SGRA_4153 SGRA_4153 SGRA_4150 SGRA_4150 ycaJ ycaJ hsdS-3 hsdS-3 SGRA_4131 SGRA_4131 SGRA_4128 SGRA_4128 comEC comEC SGRA_3958 SGRA_3958 SGRA_3957 SGRA_3957 SGRA_3935 SGRA_3935 hsdR-3 hsdR-3 SGRA_3894 SGRA_3894 hsdS-2 hsdS-2 apaG apaG katE-2 katE-2 SGRA_3869 SGRA_3869 SGRA_3856 SGRA_3856 ahpC-2 ahpC-2 SGRA_3697 SGRA_3697 SGRA_3663 SGRA_3663 SGRA_3662 SGRA_3662 SGRA_3658 SGRA_3658 hsdS hsdS SGRA_3606 SGRA_3606 SGRA_3604 SGRA_3604 SGRA_3561 SGRA_3561 SGRA_3549 SGRA_3549 phoB1-2 phoB1-2 sms sms polA polA phrB-2 phrB-2 SGRA_3483 SGRA_3483 pilH pilH SGRA_3446 SGRA_3446 SGRA_3417 SGRA_3417 SGRA_3410 SGRA_3410 SGRA_3404 SGRA_3404 hslR hslR SGRA_3379 SGRA_3379 ligA ligA msrA msrA bacA bacA SGRA_3279 SGRA_3279 rpoE-10 rpoE-10 SGRA_3264 SGRA_3264 paaE paaE SGRA_3257 SGRA_3257 SGRA_3250 SGRA_3250 cheA cheA cheB cheB cheY cheY SGRA_3220 SGRA_3220 mcp mcp SGRA_3208 SGRA_3208 SGRA_3198 SGRA_3198 recR recR SGRA_3072 SGRA_3072 ybaZ ybaZ SGRA_3038 SGRA_3038 SGRA_3037 SGRA_3037 sanA sanA SGRA_2984 SGRA_2984 SGRA_2982 SGRA_2982 SGRA_2981 SGRA_2981 ychF ychF trxB-2 trxB-2 mutL mutL SGRA_2901 SGRA_2901 ahpC ahpC ahpD ahpD sprA sprA ruvA ruvA SGRA_2669 SGRA_2669 SGRA_2643 SGRA_2643 SGRA_2609 SGRA_2609 mutS2 mutS2 xthA xthA SGRA_2572 SGRA_2572 ruvB ruvB SGRA_2515 SGRA_2515 SGRA_2472 SGRA_2472 rpoE-9 rpoE-9 dcm dcm uvrA-2 uvrA-2 rpoE-8 rpoE-8 SGRA_2395 SGRA_2395 SGRA_2394 SGRA_2394 pal-3 pal-3 flgJ-2 flgJ-2 SGRA_2285 SGRA_2285 SGRA_2262 SGRA_2262 SGRA_2259 SGRA_2259 SGRA_2251 SGRA_2251 SGRA_2219 SGRA_2219 mutY mutY uvrA uvrA mutS mutS SGRA_2115 SGRA_2115 hmp hmp recG recG SGRA_2095 SGRA_2095 SGRA_2092 SGRA_2092 SGRA_2082 SGRA_2082 SGRA_2047 SGRA_2047 SGRA_2039 SGRA_2039 arsA arsA recA recA ruvC ruvC SGRA_1973 SGRA_1973 SGRA_1950 SGRA_1950 SGRA_1857 SGRA_1857 SGRA_1856 SGRA_1856 rpoE-7 rpoE-7 uvrB uvrB SGRA_1751 SGRA_1751 SGRA_1732 SGRA_1732 SGRA_1715 SGRA_1715 mfd mfd recN recN rpoE-6 rpoE-6 rpoE-5 rpoE-5 SGRA_1604 SGRA_1604 SGRA_1575 SGRA_1575 recQ-2 recQ-2 yhfA yhfA phoR-2 phoR-2 SGRA_1541 SGRA_1541 trxB trxB SGRA_1473 SGRA_1473 ampC-2 ampC-2 SGRA_1437 SGRA_1437 recJ recJ SGRA_1375 SGRA_1375 SGRA_1355 SGRA_1355 uvrC uvrC SGRA_1279 SGRA_1279 pleC1 pleC1 phrB phrB flgJ flgJ dnaJ dnaJ SGRA_1157 SGRA_1157 msrB-2 msrB-2 recO recO SGRA_1096 SGRA_1096 msrB msrB rpoE-4 rpoE-4 rpoE-3 rpoE-3 SGRA_1025 SGRA_1025 SGRA_1023 SGRA_1023 SGRA_1012 SGRA_1012 SGRA_1011 SGRA_1011 SGRA_0994 SGRA_0994 recQ recQ katE katE SGRA_0951 SGRA_0951 SGRA_0932 SGRA_0932 SGRA_0931 SGRA_0931 SGRA_0828 SGRA_0828 SGRA_0814 SGRA_0814 SGRA_0809 SGRA_0809 nth nth SGRA_0786 SGRA_0786 ung ung SGRA_0737 SGRA_0737 rpoE-2 rpoE-2 SGRA_0706 SGRA_0706 SGRA_0674 SGRA_0674 rpoE rpoE SGRA_0622 SGRA_0622 dpx dpx SGRA_0607 SGRA_0607 degS degS SGRA_0596 SGRA_0596 SGRA_0590 SGRA_0590 SGRA_0559 SGRA_0559 SGRA_0516 SGRA_0516 SGRA_0495 SGRA_0495 SGRA_0494 SGRA_0494 SGRA_0476 SGRA_0476 SGRA_0456 SGRA_0456 SGRA_0455 SGRA_0455 SGRA_0454 SGRA_0454 SGRA_0453 SGRA_0453 SGRA_0450 SGRA_0450 SGRA_0448 SGRA_0448 recF recF dacA dacA SGRA_0403 SGRA_0403 SGRA_0401 SGRA_0401 SGRA_0400 SGRA_0400 SGRA_0390 SGRA_0390 sodA-2 sodA-2 ampC ampC SGRA_0340 SGRA_0340 SGRA_0329 SGRA_0329 SGRA_0326 SGRA_0326 nfi nfi SGRA_0305 SGRA_0305 SGRA_0301 SGRA_0301 hsdR hsdR SGRA_0289 SGRA_0289 cas1 cas1 SGRA_0275 SGRA_0275 sodA sodA phoB1 phoB1 phoR phoR SGRA_0244 SGRA_0244 SGRA_0222 SGRA_0222 cat cat SGRA_0217 SGRA_0217 SGRA_0216 SGRA_0216 SGRA_0215 SGRA_0215 SGRA_0214 SGRA_0214 SGRA_0213 SGRA_0213 SGRA_0199 SGRA_0199 SGRA_0197 SGRA_0197 SGRA_0181 SGRA_0181 SGRA_0178 SGRA_0178 SGRA_0177 SGRA_0177 SGRA_0170 SGRA_0170 SGRA_0152 SGRA_0152 SGRA_0134 SGRA_0134 SGRA_0111 SGRA_0111 SGRA_0100 SGRA_0100 lon lon SGRA_0023 SGRA_0023
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ahpC-3Antioxidant, AhpC/TSA family protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (221 aa)
rpoE-11COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (201 aa)
SGRA_4153Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (180 aa)
SGRA_4150Phosphoesterase PA-phosphatase related protein; COG0671 Membrane-associated phospholipid phosphatase. (190 aa)
ycaJRecombination factor protein RarA; COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase. (424 aa)
hsdS-3Type I restriction-modification system; COG0732 Restriction endonuclease S subunits. (430 aa)
SGRA_4131ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (751 aa)
SGRA_4128COG0610 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases. (1036 aa)
comECCOG0658 Predicted membrane metal-binding protein. (656 aa)
SGRA_3958Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (152 aa)
SGRA_3957Putative AraC family transcriptional regulator; COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain. (299 aa)
SGRA_3935Peroxiredoxin; COG0386 Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
hsdR-3Type I restriction-modification system, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1070 aa)
SGRA_3894SMC domain-containing protein; COG3950 Predicted ATP-binding protein involved in virulence. (441 aa)
hsdS-2COG0732 Restriction endonuclease S subunits. (385 aa)
apaGCo2+/Mg2+ efflux protein ApaG; COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport. (129 aa)
katE-2COG0753 Catalase. (576 aa)
SGRA_3869SMC domain-containing protein; COG3950 Predicted ATP-binding protein involved in virulence. (433 aa)
SGRA_3856Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (205 aa)
ahpC-2Antioxidant, AhpC/TSA family protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (219 aa)
SGRA_3697CRISPR-associated protein Cas6; COG1583 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (273 aa)
SGRA_3663Hypothetical protein. (270 aa)
SGRA_3662Hypothetical protein. (278 aa)
SGRA_3658COG3022 Uncharacterized protein conserved in bacteria; Belongs to the UPF0246 family. (250 aa)
hsdSRestriction modification system DNA specificity domain protein; COG0732 Restriction endonuclease S subunits. (383 aa)
SGRA_3606Hypothetical protein. (429 aa)
SGRA_3604Hypothetical protein. (678 aa)
SGRA_3561Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (217 aa)
SGRA_3549Histidine kinase; COG0642 Signal transduction histidine kinase. (326 aa)
phoB1-2Two component transcriptional regulator, winged helix family protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (235 aa)
smsDNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (464 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (927 aa)
phrB-2COG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (445 aa)
SGRA_3483Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (208 aa)
pilHTwo-component system response regulator; COG0784 FOG: CheY-like receiver. (122 aa)
SGRA_3446Histidine kinase; COG0591 Na+/proline symporter. (895 aa)
SGRA_3417Type I restriction modification enzyme protein S; COG0732 Restriction endonuclease S subunits. (364 aa)
SGRA_3410COG1555 DNA uptake protein and related DNA-binding proteins. (283 aa)
SGRA_3404ATPase-like protein; COG4637 Predicted ATPase. (354 aa)
hslRCOG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). (139 aa)
SGRA_3379COG0286 Type I restriction-modification system methyltransferase subunit. (911 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (710 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (182 aa)
bacAPutative bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (320 aa)
SGRA_3279Hypothetical protein. (146 aa)
rpoE-10RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa)
SGRA_3264Hypothetical protein. (205 aa)
paaEphenylacetate-CoA oxygenase/reductase, PaaK subunit; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. (367 aa)
SGRA_3257Hypothetical protein; COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components. (371 aa)
SGRA_3250Histidine kinase; COG0642 Signal transduction histidine kinase. (394 aa)
cheACOG0643 Chemotaxis protein histidine kinase and related kinases. (551 aa)
cheBProtein-glutamate methylesterase, two-component response regulator, chemotaxis; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa)
cheYChemotaxis response regulator (CheY); COG0784 FOG: CheY-like receiver. (127 aa)
SGRA_3220CheW protein; COG0835 Chemotaxis signal transduction protein. (167 aa)
mcpMethyl-accepting chemotaxis protein; COG2202 FOG: PAS/PAC domain. (757 aa)
SGRA_3208Two component transcriptional regulator, LuxR family; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. (175 aa)
SGRA_3198Hypothetical protein. (306 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (202 aa)
SGRA_3072COG2149 Predicted membrane protein. (106 aa)
ybaZmethylated-DNA-[protein]-cysteine S-methyltransferase; COG0350 Methylated DNA-protein cysteine methyltransferase. (104 aa)
SGRA_3038Hypothetical protein; COG1403 Restriction endonuclease. (319 aa)
SGRA_3037SMC domain protein; COG1122 ABC-type cobalt transport system, ATPase component. (620 aa)
sanAsanA protein; COG2949 Uncharacterized membrane protein. (208 aa)
SGRA_2984AAA ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (399 aa)
SGRA_2982COG1555 DNA uptake protein and related DNA-binding proteins. (689 aa)
SGRA_2981Hypothetical protein. (286 aa)
ychFGTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (367 aa)
trxB-2COG0492 Thioredoxin reductase. (313 aa)
mutLDNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (622 aa)
SGRA_2901Hypothetical protein; COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA. (678 aa)
ahpCCOG0450 Peroxiredoxin. (183 aa)
ahpDAlkylhydroperoxidase like protein, AhpD family; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (192 aa)
sprAGliding motility protein SprA. (2512 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
SGRA_2669Putative organic solvent tolerance protein OstA. (966 aa)
SGRA_2643Hypothetical protein. (532 aa)
SGRA_2609COG1988 Predicted membrane-bound metal-dependent hydrolases. (398 aa)
mutS2MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa)
xthAExodeoxyribonuclease III Xth; COG0708 Exonuclease III. (257 aa)
SGRA_2572SMC domain protein; COG4637 Predicted ATPase. (454 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (341 aa)
SGRA_2515Thioredoxin family protein; COG0526 Thiol-disulfide isomerase and thioredoxins. (180 aa)
SGRA_2472Hypothetical protein. (173 aa)
rpoE-9COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa)
dcmDNA-cytosine methyltransferase; COG0270 Site-specific DNA methylase. (418 aa)
uvrA-2UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (930 aa)
rpoE-8RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa)
SGRA_2395ECF subfamily RNA polymerase sigma-24 factor; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa)
SGRA_2394Bacterioferritin comigratory protein; COG1225 Peroxiredoxin. (157 aa)
pal-3OmpA/MotB domain-containing protein; COG0457 FOG: TPR repeat. (675 aa)
flgJ-2Mannosyl-glycoprotein endo-beta-n-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (477 aa)
SGRA_2285RNA polymerase sigma factor, sigma-70 family protein; COG1191 DNA-directed RNA polymerase specialized sigma subunit. (199 aa)
SGRA_2262Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (203 aa)
SGRA_2259MHC_I C-terminus family protein; COG0666 FOG: Ankyrin repeat. (455 aa)
SGRA_2251DNA mismatch repair protein MutS domain-containing protein; COG0249 Mismatch repair ATPase (MutS family). (589 aa)
SGRA_2219Hypothetical protein. (358 aa)
mutYA/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (402 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (884 aa)
SGRA_2115Two-component system response regulator; COG0784 FOG: CheY-like receiver. (520 aa)
hmpGlobin; COG1017 Hemoglobin-like flavoprotein; Belongs to the globin family. (389 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (702 aa)
SGRA_2095Hypothetical protein. (550 aa)
SGRA_2092Histidine kinase; COG0642 Signal transduction histidine kinase. (728 aa)
SGRA_2082Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (346 aa)
SGRA_2047Hypothetical protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. (365 aa)
SGRA_2039Hypothetical protein; Belongs to the SOS response-associated peptidase family. (216 aa)
arsAArsenite-activated ATPase (arsA) subfamily protein; COG0003 Oxyanion-translocating ATPase. (384 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (372 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (177 aa)
SGRA_1973Hypothetical protein. (325 aa)
SGRA_1950Lipoprotein; COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance. (249 aa)
SGRA_1857Two component transcriptional regulator, LuxR family protein; COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain. (280 aa)
SGRA_1856Histidine kinase; COG0642 Signal transduction histidine kinase. (771 aa)
rpoE-7RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (192 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (680 aa)
SGRA_1751Hypothetical protein. (256 aa)
SGRA_1732RNA polymerase, sigma-E factor; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa)
SGRA_1715ATP-binding protein; COG1106 Predicted ATPases. (434 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1122 aa)
recNDNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (552 aa)
rpoE-6RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (175 aa)
rpoE-5COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (213 aa)
SGRA_1604Hypothetical protein; COG0577 ABC-type antimicrobial peptide transport system, permease component. (438 aa)
SGRA_1575Antibiotic biosynthesis monooxygenase domain protein. (98 aa)
recQ-2COG0514 Superfamily II DNA helicase. (737 aa)
yhfACOG1765 Predicted redox protein, regulator of disulfide bond formation. (139 aa)
phoR-2Histidine kinase; COG0642 Signal transduction histidine kinase. (500 aa)
SGRA_1541COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (241 aa)
trxBCOG0492 Thioredoxin reductase. (339 aa)
SGRA_1473COG0861 Membrane protein TerC, possibly involved in tellurium resistance. (282 aa)
ampC-2COG2367 Beta-lactamase class A. (350 aa)
SGRA_1437Alkyl hydroperoxide reductase/ thiol specific antioxidant/ mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (415 aa)
recJCOG0608 Single-stranded DNA-specific exonuclease. (564 aa)
SGRA_1375RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (190 aa)
SGRA_1355Smr protein/MutS2; COG1193 Mismatch repair ATPase (MutS family). (365 aa)
uvrCUvrabc system protein c; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (603 aa)
SGRA_1279Hypothetical protein. (104 aa)
pleC1Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. (678 aa)
phrBCOG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (466 aa)
flgJCOG1705 Muramidase (flagellum-specific). (202 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (392 aa)
SGRA_1157Histidine kinase; COG4585 Signal transduction histidine kinase. (248 aa)
msrB-2Methionine sulfoxide reductase B; COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase; Belongs to the MsrB Met sulfoxide reductase family. (131 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (238 aa)
SGRA_1096Thioredoxin; COG0526 Thiol-disulfide isomerase and thioredoxins. (185 aa)
msrBmethionine-R-sulfoxide reductase; COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase. (175 aa)
rpoE-4RNA polymerase, sigma-24 subunit, ECF subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa)
rpoE-3RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (152 aa)
SGRA_1025ATP-dependent DNA ligase. (1056 aa)
SGRA_1023RNA-directed DNA polymerase; COG3344 Retron-type reverse transcriptase. (554 aa)
SGRA_1012Hypothetical protein. (311 aa)
SGRA_1011Hypothetical protein. (385 aa)
SGRA_09942OG-Fe(II) oxygenase; COG3145 Alkylated DNA repair protein. (212 aa)
recQATP-dependent DNA helicase, RecQ family protein; COG0514 Superfamily II DNA helicase. (2930 aa)
katECOG0753 Catalase; Belongs to the catalase family. (504 aa)
SGRA_0951Doxx family protein. (564 aa)
SGRA_0932CRISPR-associated protein, putative. (120 aa)
SGRA_0931Hypothetical protein. (350 aa)
SGRA_0828Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (389 aa)
SGRA_0814ATPase-like protein; COG1106 Predicted ATPases. (1555 aa)
SGRA_0809Alkyl hydroperoxide reductase, F52a subunit; COG0492 Thioredoxin reductase. (301 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
SGRA_0786Hypothetical protein; COG4570 Holliday junction resolvase. (186 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (226 aa)
SGRA_0737Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase; COG1705 Muramidase (flagellum-specific). (183 aa)
rpoE-2RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (195 aa)
SGRA_0706Organic hydroperoxide resistance protein; COG1764 Predicted redox protein, regulator of disulfide bond formation. (137 aa)
SGRA_0674LamG domain protein jellyroll fold domain protein. (496 aa)
rpoERNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (172 aa)
SGRA_0622COG0392 Predicted integral membrane protein. (382 aa)
dpxPHP domain protein; COG1796 DNA polymerase IV (family X). (556 aa)
SGRA_0607Alkyl hydroperoxide reductase; COG0526 Thiol-disulfide isomerase and thioredoxins. (186 aa)
degSMulti-sensor signal transduction histidine kinase; COG2202 FOG: PAS/PAC domain. (1047 aa)
SGRA_0596Hypothetical protein. (367 aa)
SGRA_0590Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (400 aa)
SGRA_0559COG0526 Thiol-disulfide isomerase and thioredoxins. (495 aa)
SGRA_0516Alkyl hydroperoxide reductase/ thiol specific antioxidant/ mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (235 aa)
SGRA_0495Two component transcriptional regulator, LytTR family protein; COG3279 Response regulator of the LytR/AlgR family. (239 aa)
SGRA_0494Signal transduction histidine kinase, LytS; COG3275 Putative regulator of cell autolysis. (354 aa)
SGRA_0476Hypothetical protein. (229 aa)
SGRA_0456Hypothetical protein. (591 aa)
SGRA_0455COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (194 aa)
SGRA_0454Hypothetical protein. (498 aa)
SGRA_0453CRISPR-associated RAMP protein; COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (558 aa)
SGRA_0450CRISPR-associated protein, TM1812 family. (407 aa)
SGRA_0448CRISPR-associated protein, TM1812 family. (441 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (372 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (256 aa)
SGRA_0403AAA ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (440 aa)
SGRA_0401SMC domain protein; COG3950 Predicted ATP-binding protein involved in virulence. (532 aa)
SGRA_0400AAA ATPase. (287 aa)
SGRA_0390Response regulator receiver protein. (307 aa)
sodA-2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (203 aa)
ampCCOG2602 Beta-lactamase class D. (274 aa)
SGRA_0340Esterase/lipase, putative; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (214 aa)
SGRA_03292OG-Fe(II) oxygenase; COG3751 Predicted proline hydroxylase. (195 aa)
SGRA_0326Histidine kinase; COG0642 Signal transduction histidine kinase. (1237 aa)
nfiEndonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (229 aa)
SGRA_0305COG4268 McrBC 5-methylcytosine restriction system component. (408 aa)
SGRA_0301Antibiotic biosynthesis monooxygenase. (99 aa)
hsdRType I site-specific deoxyribonuclease, HsdR family; Subunit R is required for both nuclease and ATPase activities, but not for modification. (936 aa)
SGRA_0289COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily). (351 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (321 aa)
SGRA_0275COG1343 Uncharacterized protein predicted to be involved in DNA repair. (98 aa)
sodAManganese/iron superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (256 aa)
phoB1COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (237 aa)
phoRHistidine kinase; COG0642 Signal transduction histidine kinase. (355 aa)
SGRA_0244Hypothetical protein; COG1106 Predicted ATPases. (399 aa)
SGRA_0222Thioredoxin family protein; COG0526 Thiol-disulfide isomerase and thioredoxins. (457 aa)
catCOG4845 Chloramphenicol O-acetyltransferase. (206 aa)
SGRA_0217CRISPR-associated protein, Csm1 family; COG1353 Predicted hydrolase of the HD superfamily (permuted catalytic motifs). (903 aa)
SGRA_0216Csm2 family CRISPR-associated protein; COG1421 Uncharacterized protein predicted to be involved in DNA repair. (156 aa)
SGRA_0215CRISPR-associated RAMP Csm3 family protein; COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (248 aa)
SGRA_0214CRISPR-associated RAMP protein, Csm4 family; COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (366 aa)
SGRA_0213CRISPR-associated RAMP protein, Csm5 family; COG1332 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily). (404 aa)
SGRA_0199COG0392 Predicted integral membrane protein. (397 aa)
SGRA_0197RNA polymerase, sigma-24 subunit, ecf subfamily protein; COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (185 aa)
SGRA_0181AAA ATPase; COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member. (427 aa)
SGRA_0178Signal transduction histidine kinase, LytS; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (352 aa)
SGRA_0177Two component transcriptional regulator, LytTR family protein; COG3279 Response regulator of the LytR/AlgR family. (234 aa)
SGRA_0170Hypothetical protein. (843 aa)
SGRA_0152Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (101 aa)
SGRA_0134Hypothetical protein; COG0577 ABC-type antimicrobial peptide transport system, permease component. (413 aa)
SGRA_0111Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (412 aa)
SGRA_0100COG4268 McrBC 5-methylcytosine restriction system component. (398 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (804 aa)
SGRA_0023Hypothetical protein. (348 aa)
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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