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| | lon | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (804 aa) |
| | SGRA_0111 | Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (412 aa) |
| | SGRA_0170 | Hypothetical protein. (843 aa) |
| | SGRA_0177 | Two component transcriptional regulator, LytTR family protein; COG3279 Response regulator of the LytR/AlgR family. (234 aa) |
| | SGRA_0178 | Signal transduction histidine kinase, LytS; COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (352 aa) |
| | SGRA_0181 | AAA ATPase; COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member. (427 aa) |
| | SGRA_0222 | Thioredoxin family protein; COG0526 Thiol-disulfide isomerase and thioredoxins. (457 aa) |
| | SGRA_0244 | Hypothetical protein; COG1106 Predicted ATPases. (399 aa) |
| | phoR | Histidine kinase; COG0642 Signal transduction histidine kinase. (355 aa) |
| | phoB1 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (237 aa) |
| | sodA | Manganese/iron superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (256 aa) |
| | SGRA_0289 | COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily). (351 aa) |
| | nfi | Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (229 aa) |
| | SGRA_0326 | Histidine kinase; COG0642 Signal transduction histidine kinase. (1237 aa) |
| | SGRA_0329 | 2OG-Fe(II) oxygenase; COG3751 Predicted proline hydroxylase. (195 aa) |
| | sodA-2 | Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (203 aa) |
| | SGRA_0390 | Response regulator receiver protein. (307 aa) |
| | SGRA_0400 | AAA ATPase. (287 aa) |
| | SGRA_0401 | SMC domain protein; COG3950 Predicted ATP-binding protein involved in virulence. (532 aa) |
| | SGRA_0403 | AAA ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (440 aa) |
| | dacA | Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (256 aa) |
| | recF | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (372 aa) |
| | SGRA_0494 | Signal transduction histidine kinase, LytS; COG3275 Putative regulator of cell autolysis. (354 aa) |
| | SGRA_0495 | Two component transcriptional regulator, LytTR family protein; COG3279 Response regulator of the LytR/AlgR family. (239 aa) |
| | SGRA_0516 | Alkyl hydroperoxide reductase/ thiol specific antioxidant/ mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (235 aa) |
| | SGRA_0559 | COG0526 Thiol-disulfide isomerase and thioredoxins. (495 aa) |
| | SGRA_0590 | Gaf sensor signal transduction histidine kinase; COG2203 FOG: GAF domain. (400 aa) |
| | SGRA_0596 | Hypothetical protein. (367 aa) |
| | degS | Multi-sensor signal transduction histidine kinase; COG2202 FOG: PAS/PAC domain. (1047 aa) |
| | SGRA_0607 | Alkyl hydroperoxide reductase; COG0526 Thiol-disulfide isomerase and thioredoxins. (186 aa) |
| | dpx | PHP domain protein; COG1796 DNA polymerase IV (family X). (556 aa) |
| | ung | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (226 aa) |
| | SGRA_0786 | Hypothetical protein; COG4570 Holliday junction resolvase. (186 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa) |
| | SGRA_0809 | Alkyl hydroperoxide reductase, F52a subunit; COG0492 Thioredoxin reductase. (301 aa) |
| | SGRA_0814 | ATPase-like protein; COG1106 Predicted ATPases. (1555 aa) |
| | SGRA_0828 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (389 aa) |
| | katE | COG0753 Catalase; Belongs to the catalase family. (504 aa) |
| | recQ | ATP-dependent DNA helicase, RecQ family protein; COG0514 Superfamily II DNA helicase. (2930 aa) |
| | SGRA_0994 | 2OG-Fe(II) oxygenase; COG3145 Alkylated DNA repair protein. (212 aa) |
| | SGRA_1012 | Hypothetical protein. (311 aa) |
| | SGRA_1025 | ATP-dependent DNA ligase. (1056 aa) |
| | SGRA_1096 | Thioredoxin; COG0526 Thiol-disulfide isomerase and thioredoxins. (185 aa) |
| | recO | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (238 aa) |
| | SGRA_1157 | Histidine kinase; COG4585 Signal transduction histidine kinase. (248 aa) |
| | phrB | COG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (466 aa) |
| | pleC1 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. (678 aa) |
| | SGRA_1279 | Hypothetical protein. (104 aa) |
| | uvrC | Uvrabc system protein c; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (603 aa) |
| | SGRA_1355 | Smr protein/MutS2; COG1193 Mismatch repair ATPase (MutS family). (365 aa) |
| | recJ | COG0608 Single-stranded DNA-specific exonuclease. (564 aa) |
| | SGRA_1437 | Alkyl hydroperoxide reductase/ thiol specific antioxidant/ mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (415 aa) |
| | SGRA_1473 | COG0861 Membrane protein TerC, possibly involved in tellurium resistance. (282 aa) |
| | trxB | COG0492 Thioredoxin reductase. (339 aa) |
| | SGRA_1541 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (241 aa) |
| | phoR-2 | Histidine kinase; COG0642 Signal transduction histidine kinase. (500 aa) |
| | yhfA | COG1765 Predicted redox protein, regulator of disulfide bond formation. (139 aa) |
| | recQ-2 | COG0514 Superfamily II DNA helicase. (737 aa) |
| | recN | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (552 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1122 aa) |
| | SGRA_1715 | ATP-binding protein; COG1106 Predicted ATPases. (434 aa) |
| | SGRA_1751 | Hypothetical protein. (256 aa) |
| | uvrB | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (680 aa) |
| | SGRA_1856 | Histidine kinase; COG0642 Signal transduction histidine kinase. (771 aa) |
| | SGRA_1857 | Two component transcriptional regulator, LuxR family protein; COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain. (280 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (177 aa) |
| | recA | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (372 aa) |
| | SGRA_2039 | Hypothetical protein; Belongs to the SOS response-associated peptidase family. (216 aa) |
| | SGRA_2047 | Hypothetical protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family. (365 aa) |
| | SGRA_2092 | Histidine kinase; COG0642 Signal transduction histidine kinase. (728 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (702 aa) |
| | SGRA_2115 | Two-component system response regulator; COG0784 FOG: CheY-like receiver. (520 aa) |
| | mutS | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (884 aa) |
| | uvrA | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa) |
| | mutY | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (402 aa) |
| | SGRA_2219 | Hypothetical protein. (358 aa) |
| | SGRA_2251 | DNA mismatch repair protein MutS domain-containing protein; COG0249 Mismatch repair ATPase (MutS family). (589 aa) |
| | SGRA_2259 | MHC_I C-terminus family protein; COG0666 FOG: Ankyrin repeat. (455 aa) |
| | SGRA_2262 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (203 aa) |
| | pal-3 | OmpA/MotB domain-containing protein; COG0457 FOG: TPR repeat. (675 aa) |
| | SGRA_2394 | Bacterioferritin comigratory protein; COG1225 Peroxiredoxin. (157 aa) |
| | uvrA-2 | UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (930 aa) |
| | SGRA_2515 | Thioredoxin family protein; COG0526 Thiol-disulfide isomerase and thioredoxins. (180 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (341 aa) |
| | SGRA_2572 | SMC domain protein; COG4637 Predicted ATPase. (454 aa) |
| | xthA | Exodeoxyribonuclease III Xth; COG0708 Exonuclease III. (257 aa) |
| | mutS2 | MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (800 aa) |
| | SGRA_2609 | COG1988 Predicted membrane-bound metal-dependent hydrolases. (398 aa) |
| | SGRA_2643 | Hypothetical protein. (532 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa) |
| | sprA | Gliding motility protein SprA. (2512 aa) |
| | ahpD | Alkylhydroperoxidase like protein, AhpD family; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (192 aa) |
| | ahpC | COG0450 Peroxiredoxin. (183 aa) |
| | SGRA_2901 | Hypothetical protein; COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA. (678 aa) |
| | mutL | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (622 aa) |
| | trxB-2 | COG0492 Thioredoxin reductase. (313 aa) |
| | SGRA_2981 | Hypothetical protein. (286 aa) |
| | SGRA_2982 | COG1555 DNA uptake protein and related DNA-binding proteins. (689 aa) |
| | SGRA_2984 | AAA ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (399 aa) |
| | SGRA_3037 | SMC domain protein; COG1122 ABC-type cobalt transport system, ATPase component. (620 aa) |
| | SGRA_3038 | Hypothetical protein; COG1403 Restriction endonuclease. (319 aa) |
| | ybaZ | methylated-DNA-[protein]-cysteine S-methyltransferase; COG0350 Methylated DNA-protein cysteine methyltransferase. (104 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (202 aa) |
| | SGRA_3198 | Hypothetical protein. (306 aa) |
| | SGRA_3220 | CheW protein; COG0835 Chemotaxis signal transduction protein. (167 aa) |
| | cheB | Protein-glutamate methylesterase, two-component response regulator, chemotaxis; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (349 aa) |
| | cheA | COG0643 Chemotaxis protein histidine kinase and related kinases. (551 aa) |
| | SGRA_3250 | Histidine kinase; COG0642 Signal transduction histidine kinase. (394 aa) |
| | SGRA_3257 | Hypothetical protein; COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components. (371 aa) |
| | SGRA_3264 | Hypothetical protein. (205 aa) |
| | ligA | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (710 aa) |
| | SGRA_3379 | COG0286 Type I restriction-modification system methyltransferase subunit. (911 aa) |
| | hslR | COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). (139 aa) |
| | SGRA_3404 | ATPase-like protein; COG4637 Predicted ATPase. (354 aa) |
| | SGRA_3410 | COG1555 DNA uptake protein and related DNA-binding proteins. (283 aa) |
| | SGRA_3446 | Histidine kinase; COG0591 Na+/proline symporter. (895 aa) |
| | pilH | Two-component system response regulator; COG0784 FOG: CheY-like receiver. (122 aa) |
| | SGRA_3483 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (208 aa) |
| | phrB-2 | COG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (445 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (927 aa) |
| | sms | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (464 aa) |
| | phoB1-2 | Two component transcriptional regulator, winged helix family protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (235 aa) |
| | SGRA_3549 | Histidine kinase; COG0642 Signal transduction histidine kinase. (326 aa) |
| | SGRA_3561 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (217 aa) |
| | SGRA_3604 | Hypothetical protein. (678 aa) |
| | SGRA_3606 | Hypothetical protein. (429 aa) |
| | ahpC-2 | Antioxidant, AhpC/TSA family protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (219 aa) |
| | SGRA_3856 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (205 aa) |
| | SGRA_3869 | SMC domain-containing protein; COG3950 Predicted ATP-binding protein involved in virulence. (433 aa) |
| | katE-2 | COG0753 Catalase. (576 aa) |
| | apaG | Co2+/Mg2+ efflux protein ApaG; COG2967 Uncharacterized protein affecting Mg2+/Co2+ transport. (129 aa) |
| | SGRA_3894 | SMC domain-containing protein; COG3950 Predicted ATP-binding protein involved in virulence. (441 aa) |
| | SGRA_3935 | Peroxiredoxin; COG0386 Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa) |
| | SGRA_3957 | Putative AraC family transcriptional regulator; COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain. (299 aa) |
| | SGRA_3958 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG1225 Peroxiredoxin. (152 aa) |
| | comEC | COG0658 Predicted membrane metal-binding protein. (656 aa) |
| | SGRA_4131 | ATPase; COG3950 Predicted ATP-binding protein involved in virulence. (751 aa) |
| | ycaJ | Recombination factor protein RarA; COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase. (424 aa) |
| | SGRA_4153 | Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; COG0526 Thiol-disulfide isomerase and thioredoxins. (180 aa) |
| | ahpC-3 | Antioxidant, AhpC/TSA family protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (221 aa) |
